Sickness and mood: inflammatory modulation of dopamine signaling

• Autorzy: Engblom D.
• Języki publikacji: EN

Abstrakty

EN

Being sick is typically a negative experience. Sickness symptoms like malaise, pain, and nausea have negative emotional components and consequently induce suffering. Whereas the depressed mood and unease induced by sickness might be adaptive under some conditions, they lead to extensive suffering in patients with chronic inflammatory diseases and cancer. We are investigating the routes by which inflammation and other pathological processes control how you feel by regulating dopaminergic signaling. Our studies using cell‑type specific genetic modifications and manipulation of neuronal activity show that inflammation-induced aversion is elicited by a long signaling chain involving circulating inflammatory mediators, brain endothelial activation, microglial activation, and prostaglandin mediated modulation of dopaminergic signaling.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2019
• Tom: 79
• Numer: Suppl.1
• Opis fizyczny: p.XXXVI-XXXVII

Twórcy

autor

Engblom D.

• Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience, Linkoping University, Linkoping, Sweden