Biochemical and medical importance of vanadium compounds

• Autorzy: Korbecki J. , Baranowska-Bosiacka I. , Gutowska I. , Chlubek D.
• Języki publikacji: EN

Abstrakty

EN

Vanadium belongs to the group of transition metals and is present in the air and soil contaminants in large urban agglomerations due to combustion of fossil fuels. It forms numerous inorganic compounds (vanadyl sulfate, sodium metavanadate, sodium orthovanadate, vanadium pentoxide) as well as complexes with organic compounds (BMOV, BEOV, METVAN). Depending on the research model, vanadium compounds exhibit antitumor or carcinogenic properties. Vanadium compounds generate ROS as a result of Fenton's reaction or of the reaction with atmospheric oxygen. They inactivate the Cdc25B2 phosphatase and lead to degradation of Cdc25C, which induces G2/M phase arrest. In cells, vanadium compounds activate numerous signaling pathways and transcription factors, including PI3K-PKB/Akt-mTOR, NF-κB, MEK1/2-ERK, that cause cell survival or increased expression and release of VEGF. Vanadium compounds inhibit p53-dependent apoptosis and promote entry into the S phase of cells containing functional p53 protein. In addition, vanadium compounds, in particular organic derivatives, have insulin-mimetic and antidiabetic properties. Vanadium compounds lower blood glucose levels in animals and in clinical trials. They also inhibit the activity of protein tyrosine phosphatase 1B. By activating the PI3K-PKB/Akt pathway, vanadium compaunds increase the cellular uptake of glucose by the GLUT4 transporter. The PKB/Akt pathway is also used to inactivate glycogen synthase kinase-3. The impact of vanadium compounds on inflammatory reactions has not been fully studied. Vanadium pentoxide causes expression of COX-2 and the release of proinflammatory cytokines in a human lung fibroblast model. Other vanadium compounds activate NF-κB in macrophages by activating IKKβ.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 2
• Opis fizyczny: p.195-200,fig.,ref.

Twórcy

autor

Korbecki J.

• Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland

autor

Baranowska-Bosiacka I.

autor

Gutowska I.

autor

Chlubek D.

Bibliografia

• Afeseh Ngwa H, Kanthasamy A, Anantharam V, Song C, Witte T, Houk R, Kanthasamy AG (2009) Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease. Toxicol Appl Pharmacol 240: 273-285. 
• Aragón AM, Altamirano-Lozano M (2001) Sperm and testicular modifications induced by subchronic treatments with vanadium (IV) in CD-1 mice. Reprod Toxicol 15: 145-151. 
• Arvai AS, Bourne Y, Hickey MJ, Tainer JA (1995) Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. J Mol Biol 249: 835-842. 
• Aureliano M, Gândara RM (2005) Decavanadate effects in biological systems. J Inorg Biochem 99: 979-985. 
• Bartosz G (2003) Obrazki z pola bitwy. In Druga twarz tlenu. pp 324-325. PWN, Warszawa (in Polish).
• Bishayee A, Oinam S, Basu M, Chatterjee M (2000) Vanadium chemoprevention of 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinogenesis: probable involvement of representative hepatic phase I and II xenobiotic metabolizing enzymes. Breast Cancer Res Treat 63: 133-145. 
• Brandão TA, Hengge AC, Johnson SJ (2010) Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J Biol Chem 285: 15874-15883. 
• Byrne AR, Kosta L (1978) Vanadium in foods and in human body fluids and tissues. Sci Total Environ 10: 17-30. 
• Chakraborty T, Swamy AH, Chatterjee A, Rana B, Shyamsundar A, Chatterjee M (2007) Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats. J Cell Biochem 101: 244-258. 
• Chen F, Demers LM, Vallyathan V, Ding M, Lu Y, Castranova V, Shi X (1999) Vanadate induction of NF-kappaB involves IkappaB kinase beta and SAPK/ERK kinase 1 in macrophages. J Biol Chem 274: 20307-20312. 
• Chien PS, Mak OT, Huang HJ (2006) Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway. Biochem Biophys Res Commun 339: 562-568. 
• Chong IW, Lin SR, Hwang JJ, Huang MS, Wang TH, Tsai MS, Hou JJ, Paulauskis JD (2000) Expression and regulation of macrophage inflammatory protein-2 gene by vanadium in mouse macrophages. Inflammation 24: 127-139. 
• Crans DC, Smee JJ, Gaidamauskas E, Yang L (2004) The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds. Chem Rev 104: 849-902. 
• Cuesta S, Francés D, García GB (2011) ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate. Neurotoxicol Teratol 33: 297-302. 
• D'Cruz OJ, Uckun FM (2001) Bis(4,7-dimethyl and 5-dinitro-1,10-phenanthroline) sulfato-oxovanadium(IV)-mediated in vivo male germ cell apoptosis. J Appl Toxicol 21: 331-339. 
• Dong Y, Narla RK, Sudbeck E, Uckun FM (2000) Synthesis, X-ray structure, and anti-leukemic activity of oxovanadium(IV) complexes. J Inorg Biochem 78: 321-330. 
• Ehrlich VA, Nersesyan AK, Atefie K, Hoelzl C, Ferk F, Bichler J, Valic E, Schaffer A, Schulte-Hermann R, Fenech M, Wagner KH, Knasmüller S (2008) Inhalative exposure to vanadium pentoxide causes DNA damage in workers: results of a multiple end point study. Environ Health Perspect 116: 1689-1693. 
• Fu Y, Wang Q, Yang XG, Yang XD, Wang K (2008) Vanadyl bisacetylacetonate induced G1/S cell cycle arrest via high-intensity ERK phosphorylation in HepG2 cells. J Biol Inorg Chem 13: 1001-1009. 
• Gao N, Ding M, Zheng JZ, Zhang Z, Leonard SS, Liu KJ, Shi X, Jiang BH (2002) Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J Biol Chem 277: 31963-31971. 
• Glasby GP, Szefer P, Geldon J, Warzocha J (2004) Heavy-metal pollution of sediments from Szczecin Lagoon and the Gdansk Basin, Poland. Sci Total Environ 330: 249-69. 
• Hansen TV, Aaseth J, Alexander J (1982) The effect of chelating agents on vanadium distribution in the rat body and on uptake by human erythrocytes. Arch Toxicol 50: 195-202. 
• Holko P, Ligeza J, Kisielewska J, Kordowiak AM, Klein A (2008) The effect of vanadyl sulphate (VOSO4) on autocrine growth of human epithelial cancer cell lines. Pol J Pathol 59: 3-8. 
• Ingram JL, Antao-Menezes A, Turpin EA, Wallace DG, Mangum JB, Pluta LJ, Thomas RS, Bonner JC (2007) Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis. Respir Res 8: 34. 
• Jaspers I, Samet JM, Erzurum S, Reed W (2000) Vanadium-induced kappaB-dependent transcription depends upon peroxide-induced activation of the p38 mitogen-activated protein kinase. Am J Respir Cell Mol Biol 23: 95-102. 
• Kaltschmidt B, Kaltschmidt C, Hofmann TG, Hehner SP, Dröge W, Schmitz ML (2000) The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus. Eur J Biochem 267: 3828-3835. 
• Kawakami N, Ueki T, Amata Y, Kanamori K, Matsuo K, Gekko K, Michibata H (2009) A novel vanadium reductase, Vanabin2, forms a possible cascade involved in electron transfer. Biochim Biophys Acta 1794: 674-679. 
• Kawakami N, Ueki T, Matsuo K, Gekko K, Michibata H (2006) Selective metal binding by Vanabin2 from the vanadium-rich ascidian, Ascidia sydneiensis samea. Biochim Biophys Acta 1760: 1096-1101. 
• Kiss T, Kiss E, Garribba E, Sakurai H (2000) Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum. J Inorg Biochem 80: 65-73. 
• Klein A, Holko P, Ligeza J, Kordowiak AM (2008) Sodium orthovanadate affects growth of some human epithelial cancer cells (A549, HTB44, DU145). Folia Biol (Krakow) 56: 115-121. 
• Kordowiak AM, Holko P (2009) Pochodne wanadu jako związki o istotnym znaczeniu biologicznym. Część I. Działanie przeciwcukrzycowe. Post Biol Kom 36: 361-376 (in Polish).
• Kordowiak AM, Klein A, Goc A, Dabroś W (2007) Comparison of the effect of VOSO4, Na3VO4 and NaVO3 on proliferation, viability and morphology of H35-19 rat hepatoma cell line. Pol J Pathol 58: 51-57. 
• Koyuturk M, Tunali S, Bolkent S, Yanardag R (2005) Effects of vanadyl sulfate on liver of streptozotocin-induced diabetic rats. Biol Trace Elem Res 104: 233-247. 
• Lapenna D, Ciofani G, Bruno C, Pierdomenico SD, Giuliani L, Giamberardino MA, Cuccurullo F (2002) Vanadyl as a catalyst of human lipoprotein oxidation. Biochem Pharmacol 63: 375-380. 
• Li J, Tong Q, Shi X, Costa M, Huang C (2005) ERKs activation and calcium signaling are both required for VEGF induction by vanadium in mouse epidermal Cl41 cells. Mol Cell Biochem 279: 25-33. 
• Li M, Smee JJ, Ding W, Crans DC (2009) Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats. J Inorg Biochem 103: 585-589. 
• Lin TS, Chang CL, Shen FM (2004) Whole blood vanadium in Taiwanese college students. Bull Environ Contam Toxicol 73: 781-786. 
• Liu TT, Liu YJ, Wang Q, Yang XG, Wang K (2012) Reactive-oxygen-species-mediated Cdc25C degradation results in differential antiproliferative activities of vanadate, tungstate, and molybdate in the PC-3 human prostate cancer cell line. J Biol Inorg Chem 17: 311-320. 
• Marcano L, Carruyo I, Fernández Y, Montiel X, Torrealba Z (2006) Determination of vanadium accumulation in onion root cells (Allium cepa L.) and its correlation with toxicity. Biocell 30: 259-267. 
• Molinuevo MS, Cortizo AM, Etcheverry SB (2008) Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells. Cancer Chemother Pharmacol 61: 767-773. 
• Morita A, Yamamoto S, Wang B, Tanaka K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M (2010) Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res 70: 257-265. 
• Nadal M, Schuhmacher M, Domingo JL (2004) Metal pollution of soils and vegetation in an area with petrochemical industry. Sci Total Environ 321: 59-69. 
• Narla RK, Chen CL, Dong Y, Uckun FM (2001) In vivo antitumor activity of bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium (IV) (METVAN [VO(SO4)(Me2-Phen)2]). Clin Cancer Res 7: 2124-2133. 
• Narla RK, Dong Y, D'Cruz OJ, Navara C, Uckun FM (2000) Bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium (IV) as a novel apoptosis-inducing anticancer agent. Clin Cancer Res 6: 1546-1556. 
• Narla RK, Dong Y, Klis D, Uckun FM (2001) Bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium (IV) as a novel antileukemic agent with matrix metalloproteinase inhibitory activity. Clin Cancer Res 7: 1094-1101. 
• Narla RK, Dong Y, Uckun FM (2001) Apoptosis inducing novel anti-leukemic agent, bis(4,7-dimethyl-1,10 phenanthroline) sulfatooxovanadium(IV) [VO(SO4)(Me2-Phen)2] depolarizes mitochondrial membranes. Leuk Lymphoma 41: 625-634. 
• Niu Y, Liu W, Tian C, Xie M, Gao L, Chen Z, Chen X, Li L (2007) Effects of bis(alpha-furancarboxylato)oxovanadium(IV) on glucose metabolism in fat-fed/streptozotocin-diabetic rats. Eur J Pharmacol 572: 213-219. 
• Parrondo R, de las Pozas A, Reiner T, Rai P, Perez-Stable C (2010) NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells. Mol Cancer 9: 182-195. 
• Połedniok J, Buhl F (2003) Speciation of vanadium in soil. Talanta 59: 1-8. 
• Pourang N, Nikouyan A, Dennis JH (2005) Trace element concentrations in fish, surficial sediments and water from northern part of the Persian Gulf. Environ Monit Assess 109: 293-316. 
• Ray RS, Ghosh B, Rana A, Chatterjee M (2007) Suppression of cell proliferation, induction of apoptosis and cell cycle arrest: chemopreventive activity of vanadium in vivo and in vitro. Int J Cancer 120: 13-23. 
• Rodríguez-Mercado JJ, Mateos-Nava RA, Altamirano-Lozano MA (2011) DNA damage induction in human cells exposed to vanadium oxides in vitro. Toxicol In Vitro 25: 1996-2002. 
• Rondini EA, Walters DM, Bauer AK (2010) Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner. Part Fibre Toxicol 7: 9. 
• Scior T, Guevara-García JA, Melendez FJ, Abdallah HH, Do QT, Bernard P (2010) Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B. Drug Des Devel Ther 4: 231-242. 
• Scior T, Mack HG, García JA, Koch W (2009) Antidiabetic Bis-Maltolato-OxoVanadium(IV): conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B. Drug Des Devel Ther 2: 221-231. 
• Soares SS, Henao F, Aureliano M, Gutiérrez-Merino C (2008) Vanadate induces necrotic death in neonatal rat cardiomyocytes through mitochondrial membrane depolarization. Chem Res Toxicol 21: 607-618. 
• Stefańska E, Ostrowska L, Czapska D, Karczewski J, Borawska M (2005) Hair vanadium content and nutritional status of students of the Medical University of Białystok. Rocz Panstw Zakl Hig 56: 157-163. 
• Suzuki K, Inageda K, Nishitai G, Matsuoka M (2007) Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: involvement of ATM pathway. Toxicol Appl Pharmacol 220: 83-91. 
• Tang H, Sun Y, Xiu Q, Lu H, Han H (2007) Cyclooxygenase-2 induction requires activation of nuclear factor of activated T-cells in Beas-2B cells after vanadium exposure and plays an anti-apoptotic role. Arch Biochem Biophys 468: 92-99. 
• Thompson KH, Lichter J, LeBel C, Scaife MC, McNeill JH, Orvig C (2009) Vanadium treatment of type 2 diabetes: a view to the future. J Inorg Biochem 103: 554-558. 
• Thompson KH, Orvig C (2006) Vanadium in diabetes: 100 years from Phase 0 to Phase I. J Inorg Biochem 100: 1925-1935. 
• Vardatsikos G, Mehdi MZ, Srivastava AK (2009) Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes to its glucoregulatory responses (review). Int J Mol Med 24: 303-309. 
• Wei D, Li M, Ding W (2007) Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats. J Biol Inorg Chem 12: 1265-1273. 
• Woo ES, Rice RL, Lazo JS (1999) Cell cycle dependent subcellular distribution of Cdc25B subtypes. Oncogene 18: 2770-2776. 
• Wozniak K, Blasiak J (2004) Vanadyl sulfate can differentially damage DNA in human lymphocytes and HeLa cells. Arch Toxicol 78: 7-15. 
• Wright MT, Belitz K (2010) Factors controlling the regional distribution of vanadium in groundwater. Ground Water 48: 515-525. 
• Yanardag R, Bolkent S, Karabulut-Bulan O, Tunali S (2003) Effects of vanadyl sulfate on kidney in experimental diabetes. Biol Trace Elem Res 95: 73-85. 
• Ye J, Ding M, Zhang X, Rojanasakul Y, Nedospasov S, Vallyathan V, Castranova V, Shi X (1999) Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions. Mol Cell Biochem 198: 193-200. 
• Zhang Z, Chen F, Huang C, Shi X (2002) Vanadate induces G2/M phase arrest in p53-deficient mouse embryo fibroblasts. J Environ Pathol Toxicol Oncol 21: 223-231. 
• Zhang Z, Gao N, He H, Huang C, Luo J, Shi X (2004) Vanadate activated Akt and promoted S phase entry. Mol Cell Biochem 255: 227-237. 
• Zhang Z, Leonard SS, Huang C, Vallyathan V, Castranova V, Shi X (2003) Role of reactive oxygen species and MAPKs in vanadate-induced G2/M phase arrest. Free Radic Biol Med 34: 1333-1342. 
• Zhao Y, Ye L, Liu H, Xia Q, Zhang Y, Yang X, Wang K (2010) Vanadium compounds induced mitochondria permeability transition pore (PTP) opening related to oxidative stress. J Inorg Biochem 104: 371-378

Uwagi

PL

Rekord w opracowaniu.