Prevalence of herpesviruses in patients with larynx and hypopharynx squamous cell carcinoma

• Autorzy: Polz D. , Polz-Dacewicz M. , Morshed K. , Pedrycz-Wieczorska A.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was the analysis of the prevalence of Herpesviridae (EBV, CMV, HSV-1) among patients with head and neck cancers (larynx and hypopharynx squamous cell carcinoma). Correlation between viral infection, HNSCC, alcohol use, tobacco smoking, demographic data (gender, age, place of residence, occupation), anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. The examination samples were collected from paraffin-blocks tissues, from 35 patients. The laboratory part of investigation involved: isolation of DNA from histopathological specimens, qualitative analysis of DNA comprising of amplification of human ß-globin gene (reference gene) fragment, electrophoresis of amplification products of the gene fragment, quantitative DNA analysis (using spectrophotometric method), and viral DNA amplified by the nested-PCR method. There was a statistically significant correlation between T and tobacco smoking, and T and alcohol use. There was no statistically significant correlation between the presence of EBV, CMV, HSV-1 and G and epidemiological features such as place of residence.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2011
• Tom: 55
• Numer: 2
• Opis fizyczny: p.177-180,ref.

Twórcy

autor

Polz D.

• Department of Otolaryngology Head and Neck Surgery, Medical University of Lublin, 20-954 Lublin, Poland

autor

Polz-Dacewicz M.

autor

Morshed K.

autor

Pedrycz-Wieczorska A.

Bibliografia

• 1. Butel J.: Viral carcinogenesis: revelation of molecular mechanism and etiology of human diseases. Carcinogenesis 2000, 21, 405-426.
• 2. Chu P.Y., Chang S.Y., Huang J.L., Tai S.K.: Different patterns of second primary malignancy patients with squamous cell carcinoma of larynx and hypopharynx. Am J Otolaryngol 2010, 31, 168-174.
• 3. Curado M., Hashibe M.: Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol 2009, 21, 194-200.
• 4. Elad S., Zadik Y., Hewson I., Hoven A., Correa E., Logan R., Elting L., Spijkervet F., Brennan M.: A systemic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridae. Support Care Cancer 2010, 18, 993-1006.
• 5. Gil Z., Fliss D.: Contemporary management of head and neck cancers. Isr Med Assoc J 2009, 11, 296- 300.
• 6. Goldenberg D., Benoit N., Begum S., Westra W., Cohen Y., Koch W., Sidransky D., Califano J.: Epstein-Barr virus in head and neck cancer assessed by quantitative polymerase chain reaction. Laryngoscope 2004, 114, 1027-1031.
• 7. Grinde B., Olsen I.: The role of viruses in oral disease. J Oral Microbiol 2010, 2, 2127-DOI: 10.3402/jom. v2i0.2127.
• 8. Kiaris H., Ergazaki M., Segas J., Spandidos D.: Detection of Epstein-Barr virus genome in squamous cell carcinoma of the larynx. Int J Biol Markers 1995, 10, 211-215.
• 9. Kis A., Feher E., Gall T., Tar I., Boda R., Toth E., Mehes G., Gergely L., Szarka K.: Epstein-Barr virus prevalence in oral squamous cell cancer and in potentially malignant oral disorders in an eastern Hungarian population. Eur J Oral Sci 2009, 117, 536-540.
• 10. Miller C., Danaher R.: Asymptomatic shedding of herpes simplex virus (HSV) in the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008, 105, 43-50.
• 11. Morshed K., Szymański M., Siwiec H., Gołąbek W.: Laryngeal cancer in farmers from Lublin region of Poland. Ann Agric Environ Med 2008, 15, 13-19.
• 12. Öksuzler Ö., Tuna E.E., Soyalic H., Özbek C., Özdem C.: Investigation of the synergism between alcohol consumption and herpes simplex virus in patients with laryngeal squamous cell cancers. Eur Arch Otorhinolaryngol 2009, 266, 1977-1982.
• 13. Philips A., Carroll D., Khan N., Moss P.: Cytomegalovirus is associated with depression and anxiety in older adults. Brain Behav Immun 2008, 22, 52-55.
• 14. Polz D., Polz-Dacewicz M., Morshed K., Jędrych M.: Prevalence of human papillomavirus (HPV) in oral and oropharynx squamous cell carcinoma. Bull Vet Inst Pulawy 2010, 54, 675-681.
• 15. Pou A., Vrabec J., Jordan J., Wilson D., Wang S., Payne D.: Prevalence of herpes simplex virus in malignant laryngeal lesion. Laryngoscope 2000, 110, 194-197.
• 16. Ragin C., Modugno F., Gollin S.: The epidemiology and risk factors of head and neck cancer: a focus on human papillomvirus. J Dent Res 2007, 86, 104-1 14.
• 17. Rutt A., Hawksnew M., Salaloff R.: Laryngeal cancer in patients younger than 30 years: a review of 99 cases. Ear Nose Throat J. 2010, 89, 189-192.
• 18. Shah K.M., Young L.S.: Epstein-Barr virus and carcinogenesis: beyond Burkitt's lymphoma. Clin Microbiol Infect 2009, 15, 982-988.
• 19. Slots J.: Herpesviruses in periodontal diseases. Periodontology 2005, 38, 33-62.
• 20. Slots J., Saygun I., Sabeti M., Kubar A .: Epstein-Barr virus in oral diseases. J Periodont Res 2006, 41, 235-244.
• 21. Wentzensen N., von Knebel Doebritz M.: Viral carcinogenesis of head and neck tumors. Pathologie. 2004, 25, 21-30.