Microbiology and drug resistance of pathogens in patients hospitalized at the nephrology department in the south of Poland

• Autorzy: Michno M. , Sydor A. , Walaszek M. , Sulowicz W.
• Języki publikacji: EN

Abstrakty

EN

A retrospective study was conducted among 498 patients with urinary tract infections (UTI) referred to our department from January 2013 to December 2015. This study was performed to evaluate the etiology of UTI and the antibiotic susceptibility profile of Escherichia coli (E.coli) as the main etiological factor in different age groups. Urine samples were examined using standard microbiological methods. Three hundred sixty-three samples (72.9%) were identified as E.coli, of which 29 (8.0%) can produce extended-spectrum β-lactamases (ESBL). E.coli was highly sensitive to imipenem (100.0%), gentamicin (91.0%), nitrofurantoin (89.4%), amikacin (88.2%), piperacillin/tazobactam (87.0%) and cephalosporins (79.7–89.5%). Low sensitivity was found in relation to fluoroquinolones (60.3–70.4%). E.coli was least sensitive to ampicillin (30.2%) and amoxicillin/clavulanic acid (49.9%). We observed a significant fall in susceptibility level to piperacillin/tazobactam (68.4% vs. 88.8%; p=0.017), amikacin (61.1% vs. 90.7%; p=0.001), gentamicin (70.0% vs. 93.2%; p=0.002), cefalexin (41.2% vs. 83.3%; p<0.001), cefotaxime (63.6% vs. 89.4%; p=0.002), ceftazidime (61.9% vs. 85.6%; p=0.008), cefepime (73.7% vs. 91.1%; p=0.025), ciprofloxacin (54.1% vs. 72.2%; p=0.024) and norfloxacin (40.5% vs. 62.5%; p=0.011) among patients with catheter-associated UTI (CAUTI) compared to those with non-CAUTI. A similar susceptibility profile was observed between different age groups. In the longevity, E.coli showed a higher sensitivity to cephalosporins than in the young-old group. E.coli susceptibility to fluoroquinolones was low, which excludes them as a first-line drug in our department. Nitrofurantoin may be used as an alternative drug to carbapenems. Monitoring of susceptibility pattern is of great importance.

Słowa kluczowe

EN

microbiology; drug resistance; pathogen; patient; nephrology; urinary infection; Escherichia coli; antimicrobial susceptibility test; Poland

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2018
• Tom: 67
• Numer: 4
• Opis fizyczny: p.517-524,ref.

Twórcy

autor

Michno M.

• Nephrology and Dialysis Centre, Department of Internal Medicine, Regional St Lukas Hospital, Tarnow, Poland

autor

Sydor A.

• Nephrology and Dialysis Centre, Department of Internal Medicine, Regional St Lukas Hospital, Tarnow, Poland

autor

Walaszek M.

• State Higher Vocational School, Tarnow, Poland

autor

Sulowicz W.

• Chair and Department of Nephrology, Jagiellonian University, Krakow, Poland

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Identyfikatory

DOI

10.21307/pjm-2018-061