Prolactin and the physiological regulation of its secretion. A review

• Autorzy: Ciechanowska M. , Misztal T. , Przekop F.
• Języki publikacji: EN

Abstrakty

EN

This review briefly summarizes recent findings on lactotrophs in the pituitary gland and extrapituitary tissues as a no homologous group cell types of different embryonic origin, morphology and biological function. They display a remarkable adaptation to altered physiological condition. Their functions are derived from structural polymorphism, local synthesis, divergent intracellular signaling pathways and target genes. Most of them are heterogenous with respect to basal hormone release, electrical activity and responsiveness to stimulatory/inhibitory factors, depending upon gender and physiological state of animal. The circulating prolactin (PRL) produced by many types of lactotrophs can act in edocrine/paracrine/autocrine manner, respectively as a hormone, growth factor, neurotransmitter or immunoregulator. At the cellular level PRL exerts mitogenic, morphogenic and secretory activity. Numerous factors of the central and peripheral origin are involved in the mechanism regulating PRL secretion, causing an increase or decrease of the hormone concentration in the circulation. The certain feedback mechanism keep the pituitary lactotrophs to be not overactive

Słowa kluczowe

EN

prolactin; pituitary hormone; physiological regulation; secretion; growth hormone; lactotroph; lactotrope zob.lactotroph; luteotrope zob.lactotroph; mammotroph zob.lactotroph; pituitary gland; localization; dopamine; salsolinol; rat; sheep

• Wydawca: -
• Czasopismo: Journal of Animal and Feed Sciences
• Rocznik: 2013
• Tom: 22
• Numer: 2
• Opis fizyczny: p.79-89,fig.,ref.

Twórcy

autor

Ciechanowska M.

• Department of Pharmacology and Toxicology, The General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland

autor

Misztal T.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

autor

Przekop F.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

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