Molecularly targeting the PI3K- Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy

• Autorzy: Wang Z. , Huang Y. , Zhang J.
• Języki publikacji: EN

Abstrakty

EN

Radiotherapy and chemotherapeutic agents that damage DNA are the current major non-surgical means of treating cancer. However, many patients develop resistances to chemotherapy drugs in their later lives. The PI3K and Ras signaling pathways are deregulated in most cancers, so molecularly targeting PI3K-Akt or Ras-MAPK signaling sensitizes many cancer types to radiotherapy and chemotherapy, but the underlying molecular mechanisms have yet to be determined. During the multi-step processes of tumorigenesis, cancer cells gain the capability to disrupt the cell cycle checkpoint and increase the activity of CDK4/6 by disrupting the PI3K, Ras, p53, and Rb signaling circuits. Recent advances have demonstrated that PI3K-Akt-mTOR signaling controls FANCD2 and ribonucleotide reductase (RNR). FANCD2 plays an important role in the resistance of cells to DNA damage agents and the activation of DNA damage checkpoints, while RNR is critical for the completion of DNA replication and repair in response to DNA damage and replication stress. Regulation of FANCD2 and RNR suggests that cancer cells depend on PI3K-Akt-mTOR signaling for survival in response to DNA damage, indicating that the PI3K-AktmTOR pathway promotes resistance to chemotherapy and radiotherapy by enhancing DNA damage repair.

Słowa kluczowe

EN

cancer cell; radiotherapy; drug; cancer; treatment; chemotherapeutic agent; molecular mechanism; rapamycin; ribonucleotide reductase; p53 protein; drug resistance; DNA damage; DNA repair

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2014
• Tom: 19
• Numer: 2
• Opis fizyczny: p.233-242,fig.,ref.

Twórcy

autor

Wang Z.

• Department of Preventive Medicine, College of Military Preventive Medicine, Third Military Medical University, Chongqing 400038, China

autor

Huang Y.

• Department of Environmental Hygiene, College of Military Preventive Medicine, Third Military Medical University, Chongqing 400038, China

autor

Zhang J.

• Department of Neurobiology, Third Military Medical University, Chongqing 400038, China

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