The aim of the study was the examine atrophy and degenerative brain changes of nine elderly animals (three monkeys, two wild cats, a likaon, a bear, a fox and horse) and to find an animal model for researching Alzheimer disease in humans. Brain hemispheres were dissected into hemispheric slabs 4.0-4.8 mm thick. Tissue samples from the brains were fixed in 10% neutral formalin, and embedded in paraffin, and then stained with hematoxylin an eosin, Nissl method, and monoclonal antibody 4G8 mAb against b-polipeptyde and neurofibrillary tangles (NFT) were stained with anti-tau monoclonal antibody. The examined animals revealed various degrees of brain atrophy neuron loss in layer III-VI in particular, lipofuscin deposit, status lacunaris, degenerative changes in the white matter, and gliosis. Lafora-like bodies were observed in licaon, horse and bear brains. The monkeys, cats, licaon, foxes, with the exception of the horse developed brain parenchymal amyloidosis-b. Two types of plaque were present, with the diffuse form being predominant. Congophilic amyloid angiopathy was observed in all the animals with the exception of the horse. NFT and amyloidosis-b was observed only in the bear brain and the latter is a good model for Alzheimer's pathology.
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