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The purpose of studies was to elaborate and estimate the usefulness of a new preparation for treatment of metritis. The Metrisan AN was made out in the National Veterinary Research Institute on the basis of the experiences of the first author. The preparation contains the neomycin, ampicyllin as free and bound form, and components intensifying phagocytosis. The investigations were carried out on the total of 406 cows with clinical symptoms of ichoroid, purulent and muco-purulent form of metritis. It was found that one intrauterine infusion of one dose of Metrisan AN causes recovery of the endometritis III and II degree. Two doses of the Metrisan AN as first treatment and one dose given intrauterine on 7th day leads to recoveries of the ichoroid or purulent puerperal metritis. The cows which became healthy as a result of treatment with Metrisan AN had good indicators of fertility: pregnancy index, conception interval, conception after first insemination, index of insemination, and culling rate. It was also found that treatment with one dose of Metrisan AN requires no withdrawal time for milk.
The study was carried out in 3 cowsheds of industrial cattle husbandry on 62 black-and white lowland breed cows of different ages. Group I - 12 cows, in which until 2 weeks after parturition the observed signs were recognised as metritis ichorosa. Each cow was treated by an intrauterine infusion of two doses (two 10 ml injectors) of Metrisan, and intramuscular injection of prostaglandin. A systematic antibiotic treatment was used in the cows showing a rise in internal body temperature. Group II - 20 cows, in which during 2-4 weeks after parturition endometritis of the 3rd and 2nd degree was diagnosed. Each cow was treated with one dose of examination from 24 cows of group I and II before the infusion. Group III - 30 cows, in which signs of disease were not noticed, were the control group. The efficacy of the treatment was estimated every 7 days. The treated cows were administered the preparation twice or three times until the uterus was recognised as recovered. Altogether 10 cows were qualified for insemination (83.33%) from group I and 20 cows (100%) from group II. The bacteriological examination showed the presence of non-specific microorganisms in 19 cows (79.17%). Due to infertility, 7 cows (21.88%) were culled in the group of the cows treated with Metrisan and 3 cows (10%) in the control group. The mean calving interval for the cows treated with Metrisan was 116.4 days and did not differ significantly from the duration of this parameter in the control group (106.5 days).
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