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The aim of investigations was the description of changes in the lenses of dogs with senile cataract. The study was conducted on 52 dogs (from a group of 125 cases of cataract) of mixed breed and pedigree, both sexes, aged 8-20 years, originating from the Lublin area. Senile cataract was stated on the base of clinical and ophthalmological examination, dogs with secondary local or systemic infections were excluded. Senile cataracts were most often noted in mixed breed (36 dogs - 61.5% cases) followed by Spaniels, Terriers, German Shepherds and Poodles. Among all cases the disease was more frequently noted in males (32 dogs, 61.5%) rather than bitches (20 dogs, 38.5%). In 36 dogs (69%) the disease had evolved from the nucleus of the lens, but in the remaining animals (31% cases) the cataract had a cortex origin. The course of senile cataract is bilateral, but not equal and not symmetrical. The mature form evolution has a 2 year course, independently of the eye or origin.
The findings of the treatment of dogs with senile cataract have been presented in the paper. Crioextraction of the lens was performed on 190 dogs aged 10.6 years (average value). By the tight chamber closing the proper pressure inside the eyeball was restored in 2-3 minutes after the operation. On the 8th day after the surgical procedure the wound was healed, primarily due to the modification of the method of conjunctiva and cornea anastomosis. Between the 4th and 6th week after the surgery, in 60% of dogs under the operation vision capability was determined. In other dogs the improvement was not recorded because of intraoperative retinopathy, glaucoma and other causes. The number of postoperative complications was significantly higher in the group of the oldest animals. On the basis of the results crioextraction is recommended as soon as a complite loss of vision is diagnosed.
Purpose: Oxidative mechanisms play a major role in the etiology and pathogenesis of cataract, especially age-related cataract (ARC). Our study aimed to investigate the serum vitamin E level and the activities of systemic antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPX) in the blood of dogs with age-related cataract but without any general diseases. Material and methods: The population examined consisted of 40 dogs of various breeds and both sexes, aged 10-16 years, diagnosed with age-related cataract. Cataract was diagnosed by complete ocular examination. Blood was collected during clinical examination from the external jugular vein in dogs weighing less than 20 kg or from the small saphenous vein in dogs weighing over 20 kg. The control group consisted of 10 healthy dogs of different breeds and sexes, aged 8-12 years, without cataract. SOD and GPX were measured by a colorimetric reagent kit Randox SOD and Randox GPX. The level of vitamin E was determined using a Perkin-Elmer LS 30 luminescent spectrometer. This apparatus determines the vitamin E level by the fluorometric method of Hansen and Warwick . Results: The results showed a significantly lower activity of SOD as well as a lower activity of GPX and a lower level of the vitamin E in dogs with ARC compared to healthy dogs. Conclusions: The results obtained indicate a weakening of the general antioxidant defence system in the course of ARC in dogs. These results suggest that such conditions may have effect on the development of canine age-related cataract and are consistent with the free radical theory of age-related cataract development.
Purpose: The aim of the study was to evaluate the content of malondialdehyde (MDA) and the activity of the total antioxidant status (TAS) in the aqueous humor of dogs with senile cataract without general conditions. Material and methods: The population examined consisted of 40 dogs of various breeds and sexes, aged 10-16 years, diagnosed with senile cataracts, which qualified for cataract surgery. Samples of the aqueous humor were collected at the beginning of the operation, after the opening of the anterior chamber. MDA luminescence spectra were determined with a Perkin-Elmer LS 30 by the method of Yagi. TAS was measured by a colorimetric reagent kit Randox Total Antioxidant Status. Results: Our results showed a significant increase in malondialdehyde (MDA) levels and a significantly lower activity of the total antioxidant status (TAS) in the aqueous humor of dogs with senile cataract compared to the control group. Conclusions: The results indicate an increased peroxidation of lipids and a local weakening of the defensive system in the aqueous humor of dogs with senile cataract. These results suggest that these conditions may have an impact on the development of age-related cataract, and are compatible with the free-radical theory of the development of senile cataract.
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