Besides barley and wheat, the grape-vine is the third cultivar whose fate is intrinsically connected with the history of mankind. Wine was probably invented by inhabitants of present Armenia, on the threshold of civilisation, some 8,000-1,0000 years ago. It was probably they or their successors who began cultivating the grape-vine already in the Neolithic age, and they planted a number of grape-vine varieties. The article, a part of the cycle on the history of cultivars, discusses cultivating the grape-vine and making wine in the past.