Wyniki wyszukiwania

1

Regulatory effects of 1,25-dihydroxyvitamin D3 on vascular smooth muscle cells

100%

Tukaj S., Trzonkowski P., Tukaj C.

Acta Biochimica Polonica

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2012

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tom 59

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nr 3

Inflammatory response has been recognized as a central feature in the development and progression of atherosclerosis, and VSMCs (Vascular Smooth Muscle Cells) - the main cellular component of media, play an important role in this process. Many reports indicate that the biologically active vitamin D metabolite - 1,25-dihydroxyvitamin D3 (1,25(OH)2D3 = calcitriol), besides its well established role in calcium homeostasis, plays an essential role in the regulation of the inflammation process. The aim of this study was to determine the regulatory effects of calcitriol, applied at two supra-physiological doses (10 nM and 100 nM), in VSMC culture. Secretion of the pro-inflammatory cytokines, IL-6 and TNF-α, was significantly attenuated in calcitriol-treated VSMC culture, but the level of anti-inflammatory TGF-β was generally unchanged. Since in advanced atherosclerosis lesions several cell types, including VSMCs, overproduce the HSP70 chaperone protein, we also checked the effects of calcitriol on its synthesis. The presence of 1,25(OH)2D3 did not affect HSP70 synthesis under physiological conditions but the synthesis of HSP70 in VSMCs exposed to heat shock was significantly inhibited by calcitriol (=100 nM). We observed that 1,25(OH)2D3 induced SOD 1 activity, stimulated the expression of IκB-α, and did not influence the level of NF-κB-p65 in VSMCs. The results of our study suggest that 1,25(OH)2D3 may serve as a natural anti-inflammatory agent and may therefore play a beneficial role in the physiology of VSMC in some contexts of atherosclerosis.

2

Efficacy of 25-hydroxycholecalciferol in laying hens

100%

Rutkowski A., Kaczmarek S., Wiaz M., Stanislawski P., Jozefiak D.

Polish Journal of Natural Sciences. Supplement

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2006

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tom 03

511-516

3

The effect of calcitriol analogues on the proliferation of thyroid medullary carcinoma cells and on the expression of the calcitonin gene

100%

Flig K., Gebarowska E., Zabel M.

Cellular and Molecular Biology Letters

|

2002

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tom 07

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nr Suppl.

4

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Effect of vitamin D3 on chymotrypsin activity in the droppings of laying hens after an exposure to cadmium

100%

Korenek M., Vasko L., Korenekova B., Jackova A., Skalicka M., Siklenka P., Kottferova J., Slesarova L., Sutiak V., Neuschl J., Lohajova L.

Bulletin of the Veterinary Institute in Puławy

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2000

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tom 44

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nr 2

Effect of both vitamin D₃ and cadmium (Cd) on chymotrypsin activity (ACHT) of laying hen has been studied. Ten month-old laying hens were fed a compound feed of HYD-10 ad libitum. The birds were divided into 8 groups (each group consisting of 6 birds) as follows: experimental groups G1, G3, and G5 were supplemented with Cd (0.3; 0.6; and 6.0 mg.kg⁻¹ CdCl₂, respectively) groups G2, G4, and G6 were supplemented with vitamin D₃ (100 I.U./day) at the same Cd concentrations. C₁ was control group without any supplements and C₂ was control group supplemented only with vitamin D₃. The study lasted 6 months. In groups G1-G4, ACHT activities in the end of the study were rather high (2097.4; 2984; 1805.4, and 2575.9 U.g⁻¹,respectively). The ACHT activity in groups G2, G4 and G6 was by little higher than that in groups G1, G3, and G5 without vitamin D₃ supplementation. The principle of the action of vitamin D₃ via Ca ions and calmodulin is further discussed.

5

Effect of administration of two forms of vitamin D in a feed mixture on the strength traits of the femur bone of broiler chickens

84%

Michalczuk M., Szara T., Bereznowski A., Serwa U., Winkowski M.

Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego

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2010

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tom 06

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nr 2

6

Vitamin D3 (cholecalciferol) boosts hydrogen sulphide tissue concentrations in heart and other mouse organs

84%

Wilinski B., Wilinski J., Somogyi E., Piotrowska J., Opoka W.

Folia Biologica

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2012

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tom 60

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nr 3-4

7

Retinol, alpha-tocopherol and vitamin D3 in white muscle disease

84%

Mert H., Yildirim S., Yoruk I. H., Irak K., Comba B., Mert I., Aysin N., Comba A.

Medycyna Weterynaryjna

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2018

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tom 74

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nr 07

Vitamins are essential for the health of all living organisms. Vitamins E, A, D and K are known as fatsoluble vitamins, and deprivation of vitamin E causes various disorders, especially in the reproduction and cardiovascular systems and in muscle functions. Vitamin A, on the other hand, has roles in various biological functions – like eyesight – and the growth, reproduction and differentiation of epithelial cells. Vitamin A deficiency leads to the keratinization of the epithelium, and disorders related to the metaplasies of the genital and genitourinary systems. Conversely, vitamin D is defined as a pro-hormone and is responsible for Cahomeostasis, and thus indirectly affects the bone metabolism, bone structure, and cellular and neural functions of Ca. White Muscle Disease (WMD) can occur in newborn lambs, but is more commonly seen in lambs of up to 3 months of age. In this study, 30 lambs of 3 to 50-days-old from different flocks diagnosed with White Muscle Disease (WMD) were selected as research material, while the control group consisted of 8 healthy lambs. With the aim of clarifying the cause of WMD, serum fat-soluble vitamins, retinol, α-tocopherol and vitamin D3 levels were determined in 16 lambs. Gluteal and heart musclet issue samples also were taken from 30 lambs with WMD. The vitamin levels of the samples were analysed by HPLC. The levels of serum α-tocopherol, retinols, and vitamin D3 were foundto be low in the diseased animals, but only retinol (p < 0.001) and α-tocopherol (p < 0.001) level differences were statistically relevant. Macroscopically, Zenker’s necrosis was determined in the heart muscles of 17 lambs, and in the gluteal and chest muscles of 6 lambs. 7 lambs displayed necrosis in both their heart and in gluteal muscles. The samples were analyzed microscopically to reach similar findings: swollen homogeneous pink muscles, pycnotic nuclei, and hyperaemic and haemorrhagic blood vessels in gluteal, chest and heart muscles. Hyaline degeneration and Zenker’s necrosis, dystrophic regions in necrotic areas, cc was detected as a severe disease in lambs at an early stage of life with advanced degeneration in different muscle tissues. Deficiency of fat-soluble vitamins was also detected in the sick animals. Control group lambs had higher levels of α-tocopherol and retinol (p < 0.001) compared to the sick lambs.

8

Health outcomes of vitamin D. Part I. Characteristics and classic role

84%

Wranicz J., Szostak-Wegierek D.

Roczniki Państwowego Zakładu Higieny

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2014

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tom 65

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nr 3

Vitamin D is a compound responsible for maintaining mineral homeostasis. It protects against calcium and phosphate deficiency through the effects on the intestine, kidney, parathyroid gland and bone. All mechanisms that help maintain mineral homeostasis of the body are regulated by the vitamin D hormonal form - calcitriol. Synthesis of vitamin D starts in the skin as a non-enzymatic process, which begins during exposure to sunlight, when the absorption of ultraviolet B (UVB) radiation results in convertion of 7-dehydrocholesterol, a metabolite of cholesterol that is stored in the skin, to precholecalciferol (previtamin-D3) that is immediately converted into cholecalciferol (vitamin D3). After the skin synthesis cholecalciferol is transported to the liver where it undergoes hydroxylation, what results in formation of calcidiol (25(OH) D3). The second metabolic process takes place in the kidney, where calcidiol undergoes hydroxylation at the C-1 position to the hormonal, the most active metabolite - 1,25-dihydroxyvitamin D (calcitriol). Vitamin D deficiency may result in bone diseases, such as rickets in children and osteomalacia and osteoporosis in adults. Symptoms of osteomalacia affect mainly the skeletal system and are similar to that observed in rickets. It concerns thoracic kyphosis, pelvis deformities and also the varus knee. Osteoporosis is another condition that is related to abnormalities of mineral homeostasis. It is characterized by the progressive loss of bone mass, impaired bone microarchitecture, and consequently increased fragility and susceptibility to fracture. For the last several years other, non-classic actions of vitamin D3 have been discussed. It was engendered by the discovery of vitamin D3 receptor (VDR) in the most of body tissues and cells. Hence, there are many hypotheses which suggest the inverse relationship between vitamin D status and various diseases, such as cancer, autoimmune diseases, diabetes mellitus and others.

9

Vitamin D in SARS-CoV-2 infection

84%

Decyk A., Kobylinska M., Antosik K., Kurowska K.

Roczniki Państwowego Zakładu Higieny

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2022

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tom 73

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nr 1

Background. SARS-CoV-2 virus is one of the largest RNA viruses, included in the coronavirus group, showing tropism to airway epithelial cells. SARS-CoV-2 causes an acute respiratory infectious disease, Covid-19. According to WHO reports, mortality due to Covid-19 is higher in the elderly and in those burdened with comorbidities such as diabetes, obstructive pulmonary disease, coronary artery disease, cancer, hypertension, hepatitis B, obesity or chronic kidney disease. Objective. The aim of the study was to review the current literature on the influence and importance of vitamin D levels on the course of SARS-CoV-2 infection. Material and method. A systematic review of studies published from January 1, 2009 to June 31, 2021 has been performed. For this purpose, bibliographic databases such as PubMed and Scopus were searched. The following keywords and combinations were used: Covid-19, vitamin D, 25-hydroxy-vitamin D, vitamin D supplementation, SARS-CoV-2. Results. It has been shown that vitamin D plays an important role in the mechanisms of the innate immunity in the course of the acute respiratory infections. The overlapping factors of the severity of COVID-19 disease, vitamin D deficiency, and the prevalence of obesity, age scare, ethnicity, has led some researchers to hypothesize that vitamin D supplementation may be promising as a preventive or therapeutic measure for COVID-19. Conclusions. A very important factor that has an immunomodulatory character is vitamin D, the adequate supplementation of which can be a preventive or therapeutic measure in case of SARS-CoV-2 infection, especially in elderly people, with obesity and other chronic diseases.

10

Effect of vitamin D3-enriched diet on intestinal calcium absorption in rats intoxicated with carbaryl and thiram

84%

Witkowska D., Oledzka R., Sedrowicz L., Duliban D., Szelachowska M.

Polish Journal of Food and Nutrition Sciences

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1992

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tom 01

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nr 4

11

Myocardial necrosis due to vitamin D3 overdose - scanning electron microscopic observations

84%

Walentynowicz O., Kubasik-Juraniec J., Rudzinska-Kisiel T.

Folia Morphologica

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2004

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tom 63

|

nr 4

Our studies were carried out on the hearts of virgin female Wistar rats treated with 100.000 i.u. of vitamin D₃ (calciol) per os for 3 consecutive days. Multifocal cardionecrosis was established macroscopically in 70% of the vitamin D-treated rats on the 7th day of the experiment when the rats were in the acute phase of intoxication. Using a scanning electron microscopy (SEM), we received three-dimensional information about the structural changes to the rat myocardium damaged by high doses of vitamin D₃. The images of necrotic hearts revealed significant disruption of the structural integrity of the myocardium linked to fragmentation of the cardiac muscle bundles and a visible disruption of the extracellular matrix (ECM) components. In healthy hearts, the structural integrity of the myocardium and the dense network of the extracellular matrix were well preserved. In parallel, the effect of an increasing concentration of free Ca²⁺ on the total proteolytic activity of the heart muscle homogenate of the healthy and necrotic rats was investigated at neutral pH. These data showed that following vitamin D₃ intoxication, the proteolytic processes in the rat hearts occurred in Ca²⁺ overload or saturation. On the basis of our morphological and biochemical results we can suggest that calcium-activated neutral proteinases may have contributed to the structural alteration of the extracellular matrix components and were in this way involved in vitamin D-induced cardionecrosis.

12

Effect of season on plasma concentration of insulin-like growth factor-I and 1.25-dihydroxycholecalciferol in horses

67%

Luszczynski J., Pieszka M.

Acta Scientiarum Polonorum. Zootechnica

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2011

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tom 10

|

nr 3

During the summer season, plasma concentrations of insulin-like growth factor I (IGF-I) inArabian,Anglo-Arabian and Hucul horses as well as colts and fillies were higher compared to the winter season. Significant differences in IGF-I concentration between the seasons were found in Hucul horses (P≤0.01) and in colts (P≤0.05). Season had no significant effect on 1.25(OH)2-D3 concentration in the horse breeds studied. However, plasma concentrations of this hormone were always higher in the summer than in the winter season regardless of the breed (exceptAnglo-Arabians) and sex. Knowledge and monitoring of the physiological concentrations of IGF-1 and vitamin D3 metabolites in different seasons of the year, combined with analysis of growth rate during these periods may contribute to the improvement of the horse management and feeding system. Because of the association between these hormones and the frequency of developmental orthopaedic diseases, this information could be potentially used in veterinary practice.

13

The relationship between vitamin D3 and insulin in polycystic ovary syndrome - a critical review

67%

Kaminska K., Grzesiak M.

Journal of Physiology and Pharmacology

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2021

|

tom 72

|

nr 1

14

Zanikanie 3H witaminy D3 z surowicy szczurow narazonych na dzialanie tiuramu

67%

Witkowska D., Sedrowicz L.

Bromatologia i Chemia Toksykologiczna

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1995

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tom 28

|

nr 4

323-329

Zanikanie 3H witaminy D3 w surowicy krwi badano na szczurach samcach szczepu Wistar narażonych na działanie tiuramu przez 2 tygodnie. W oparciu o otwarty model dwukompartmentowy wyznaczono podstawowe parametry farmakokinetyczne, tj. biologiczny okres póltrwania – t0,5, stałe szybkości dystrybucji (k12 i k21) oraz stalą eliminacji (k13).

15

Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells

67%

Marcinkowska E., Kutner A.

Acta Biochimica Polonica

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2002

|

tom 49

|

nr 2

Synthetic analogs of vitamin D for potential use in differentiation therapy should selectively regulate genes necessary for differentiation without inducing any perturbations in calcium homeostasis. PRI-1906, an analog of vitamin D2, and PRI-2191, an analog of vitamin D3 bind nuclear vitamin D receptor (nVDR) with substantially lower affinity than 1,25-dihydroxyvitamin D3 (1,25-D3), but have higher differentiation-inducing activity as estimated in HL-60 leukemia cell model. To examine how their increased differentiation-inducing activity is regulated we tested the hypothesis that membrane-mediated events, unrelated to nVDR, take part in the differentiation in response to PRI-1906 and PRI-2191. The induction of leukemia cell differentiation in response to the analogs of vitamin D was inhibited by LY294002 (phosphatidyl- inositol 3-kinase inhibitor), PD98059 (inhibitor of MEK1,2, an upstream regulator of extracellular-signal regulated kinase) and rapamycin (p70 S6K inhibitor) pointing out that activation of signal transduction pathways unrelated to nVDR is necessary for differentiation. On the other hand, inhibition of cytosolic phospholipase A2 accelerated the differentiation of HL-60 cells induced by either 1,25-D3 or by the vitamin D analogs suggesting possible existence of a feedback loop between extracellular-signal regulated kinases and phospholipase A2.

16

The in vitro interaction of C 27-sterols with the erythrocyte membranes depends on the sterol structure and concentration

67%

Tuganova A. V., Kotsyuruba A. V.

Cellular and Molecular Biology Letters

|

1996

|

tom 01

|

nr 2

We tested in vitro the role of functional groups and overall structure of sterol skeleton as well as sterol concentration in the ability of erythrocyte membranes to accumulate C27-sterol molecules. It is established that association with erythrocyte membranes of C27-sterols: cholesterol, 7-dehydrocholesterol, cholecalciferol (vitamin D3), calcitriol (lα,25-dihydroxycholecalciferol), ecdysterone (20-hydroxyecdysone) and 2-desoxyecdysterone depends on sterols concentrations and structure.

17

Effect of thiram on calcium metabolism and vitamin D3 metabolites synthesis in rats

67%

Witkowska D., Sedrowicz L.

Acta Poloniae Toxicologica

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1995

|

tom 03

|

nr 1

18

Dieta jak lekarstwo

59%

Gajewska D.

Przegląd Gastronomiczny

|

2001

|

tom 54

|

nr 01

9

19

Poziom wybranych wskaznikow biochemicznych we krwi szczurow eksponowanych na ozon i otrzymujacych iniekcje witaminy A i D3

51%

Jedlinska-Krakowska M., Jakubowski K., Kowalski A.

Acta Scientiarum Polonorum. Medicina Veterinaria

|

2004

|

tom 03

|

nr 1

79-84

20

Wplyw beta-karotenu i witamin A, D3, E na wykorzystanie skladnikow mineralnych z dawki pokarmowej stosowanej w zywieniu cielat

51%

Iwanska S., Strusinska D., Pysera B.

Acta Academiae Agriculturae ac Technicae Olstenensis. Zootechnica

|

1992

|

tom 36

35-46

W badaniach na cielętach rasy ncb od urodzenia do 13. tygodnia życia stwierdzono statystycznie istotny wpływ podawania dodatku Rovimixu β-caratene 10% lub suszu z marchwi na wykorzystacie wapnia, fosforu, magnezu, żelaza, miedzi i cynku z dawek pokarmowych. Najlepsze wykorzystanie obserwowano przy stosowaniu naturalnego lub syntetycznego β-karotenu z witaminami AD3E. Wzrost koncentracji badanych składników mineralnych stwierdzono w surowicy brwi już w pierwszym tygodniu po urodzeniu, a w 12. tygodniu życia cieląt zawartość wapnia była wyższa o 30-35%, fosforu 15-21%, magnezu - 11%, żelaza i cynku o 17-22% oraz miedzi - 28-45% i ceruloplazminy o 16-24% w porównaniu z grupą cieląt kontrolnych.

Ograniczanie wyników

Regulatory effects of 1,25-dihydroxyvitamin D3 on vascular smooth muscle cells

Efficacy of 25-hydroxycholecalciferol in laying hens

The effect of calcitriol analogues on the proliferation of thyroid medullary carcinoma cells and on the expression of the calcitonin gene

Effect of vitamin D3 on chymotrypsin activity in the droppings of laying hens after an exposure to cadmium

Effect of administration of two forms of vitamin D in a feed mixture on the strength traits of the femur bone of broiler chickens

Vitamin D3 (cholecalciferol) boosts hydrogen sulphide tissue concentrations in heart and other mouse organs

Retinol, alpha-tocopherol and vitamin D3 in white muscle disease

Health outcomes of vitamin D. Part I. Characteristics and classic role

Vitamin D in SARS-CoV-2 infection

Effect of vitamin D3-enriched diet on intestinal calcium absorption in rats intoxicated with carbaryl and thiram

Myocardial necrosis due to vitamin D3 overdose - scanning electron microscopic observations

Effect of season on plasma concentration of insulin-like growth factor-I and 1.25-dihydroxycholecalciferol in horses

The relationship between vitamin D3 and insulin in polycystic ovary syndrome - a critical review

Zanikanie 3H witaminy D3 z surowicy szczurow narazonych na dzialanie tiuramu

Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells

The in vitro interaction of C 27-sterols with the erythrocyte membranes depends on the sterol structure and concentration

Effect of thiram on calcium metabolism and vitamin D3 metabolites synthesis in rats

Dieta jak lekarstwo

Poziom wybranych wskaznikow biochemicznych we krwi szczurow eksponowanych na ozon i otrzymujacych iniekcje witaminy A i D3

Wplyw beta-karotenu i witamin A, D3, E na wykorzystanie skladnikow mineralnych z dawki pokarmowej stosowanej w zywieniu cielat