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1

Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication

100%
Schang L. M.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 2A
2

Mass production of nucleopolyhedrovirus of the satin moth Leucoma salicis [LesaNPV]

84%
Ziemnicka J.
Journal of Plant Protection Research
|
2007
|
tom 47
|
nr 4
457-467
Nucleopolyhedrovirus (NPV) of the satin moth Leucoma (=Stilpnotia) salicis L. was produced by infecting the larvae with the LesaNPV strain obtained from epizootic center in Katowice. The infected larvae were reared under laboratory, greenhouse and insectarium conditions. Because L. salicis can not be reared on a semi-synthetic food, the insects were maintained on natural products. Efficiency of the mass virus production depended on an insect growth stage, virus concentration and number of infected larvae in a rearing container. The fourth-instar larvae were the best for LesaNPV replication. Inoculation of younger larval stages (third instar stadium) provided less number of inclusion bodies (insects were dying sooner and did not meet their maximum body weight). On the contrary inoculation of older stages (fifth and sixth instars) resulted in slower virus replication and low larva mortality. The virus concentration of 3 x 109 of inclusion bodies per container was the optimum inoculum for the mass virus production (double infection with the virus concentration of 1.5 x 109 inclusion bodies/1000 larvae). The larvae reared at high-density became more infected and it caused their earlier death and in consequences low virus efficiency. Rearing the insect at low density (less than 10 larvae per 1.0L container) was conducive for both an increase of insect body mass and virus replication as well. The highest number of inclusion bodies per one larva (5.3 x 109-7.7 x 109) and the highest total number of inclusion bodies (152 x 1011-188 x 1011) were achieved under these rearing conditions in a greenhouse and insectarium.
3

Effect of KLP-602 on virus replication in cell cultures

84%
Malaczewska J., Rotkiewicz Z.
Polish Journal of Veterinary Sciences
|
2004
|
tom 07
|
nr 2
4

Effect of methisoprinol and KLP-602 on virus replication in chicken embryos

84%
Malaczewska J., Rotkiewicz Z.
Polish Journal of Veterinary Sciences
|
2005
|
tom 08
|
nr 4
5

Effect of methisoprinol on virus replication in cell cultures

84%
Malaczewska J., Rotkiewicz Z.
Polish Journal of Veterinary Sciences
|
2004
|
tom 07
|
nr 2
6

Effect of exogenous tumor necrosis factor alpha, interleukin 6 and interferons on vesicular stomatitis virus replication in human placenta and amniotic membrane organ cultures

84%
Paradowska E., Blach-Olszewska Z., Gierlinska M., Woyton J.
Archivum Immunologiae et Therapiae Experimentalis
|
1996
|
tom 44
|
nr 1
7

Occurrence of main Marek's disease genes during infection of chickens

67%
Wozniakowski G., Samorek-Salamonowicz E., Kozdrun W.
Bulletin of the Veterinary Institute in Puławy
|
2010
|
tom 54
|
nr 2
123-127
The aim of this study was the determination of the occurence of ICP4, pp38, meq, and LAT genes of Marek's disease virus (MDV) and its rate of replication in internal organs of infected chickens. The genes were determined using PCR, while the virus replication was measured by real-time PCR method. The results have shown the presence of ICP4 and pp38 genes starting from the 3rd d p.i. while meq oncogene was detected from the 7 d p.i. During the whole period of the experiment, no presence of latency associated transcript gene (LAT) was found. The virus replicated most intensively in the spleen and bursa of Fabricius then in the thymus, liver, and lungs. The results imply a role of the main genes ICP4 and pp38 in early cytolytic infection of chickens, and the further occurrence of meq oncogene associated with tumourgenesis. The highest dynamics of MDV replication in the lymphoid organs - bursa of Fabricius, thymus, and spleen indicates its stringent association with lymphoid cells and tissues.
8
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Pathogenesis and clinical consequences of iron overload in chronic hepatitis C - impact of host and viral factors related to iron metabolism

67%
Sikorska K., Romanowski T., Bielawski K. P.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2011
|
tom 92
|
nr 1
9

Acquirement of susceptibility to vesicular stomatitis virus infection by murine resident peritoneal cells during culturing in vitro

67%
Orzechowska B., Blach-Olszewska Z.
Archivum Immunologiae et Therapiae Experimentalis
|
1996
|
tom 44
|
nr 5-6
10

Treatment of six patients with chronic active HCV hepatitis, with low dose natural human interferon alpha administered orally

67%
Zielinska W., Paszkiewicz J., Korczak A., Wlasiuk M., Zoltowska A., Szutowicz A., Cummins J. M., Georgiades J. A.
Archivum Immunologiae et Therapiae Experimentalis
|
1993
|
tom 41
|
nr 3-4
11

Individual differentiation of innate antiviral immunity in humans; the role of endogenous interferons and tumor necrosis factor in the immunity of leukocytes

59%
Orzechowska B., Antoszkow Z., Blach-Olszewska Z.
Archivum Immunologiae et Therapiae Experimentalis
|
2003
|
tom 51
|
nr 1
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