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  1. 30 Journal of Physiology and Pharmacology

  2. 9 Archivum Immunologiae et Therapiae Experimentalis

  3. 9 Journal of Physiology and Pharmacology. Supplement

  4. 4 Acta Biochimica Polonica

  5. 3 Folia Histochemica et Cytobiologica

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  1. 7 Brzozowski T.

  2. 6 Celinski K.

  3. 6 Mach T.

  4. 5 Slomka M.

  5. 4 Drews M.

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  1. 1 2021

  2. 3 2020

  3. 1 2019

  4. 4 2018

  5. 2 2017

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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Sleep disturbance and disease activity in adult patients with inflammatory bowel diseases

100%
Sobolewska-Wlodarczyk A., Wlodarczyk M., Banasik J., Gasiorowska A., Wisniewska-Jarosinska M., Fichna J.
Journal of Physiology and Pharmacology
|
2018
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tom 69
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nr 3
2
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Inflammatory bowel diseases and brain-gut axis

100%
Hollander D.
Journal of Physiology and Pharmacology. Supplement
|
2003
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tom 54
|
nr 4
183-190
The influence of stress on inflammation in inflammatory bowel disease (IBD) is reviewed. In experimental forms of colitis in rats, stress reactivated the disease. A study of stable IBD patients who were followed for over five years explored the influence of stress on exacerbating the disease. Those patients with high prolonged stressful life events were found to have a 90% recurrence rate of their colitis as compared to only 40% recurrence in low stress patients. Some of the mediators of stress include VIP, TNFalpha, heat shock proteins, glucocorticoid and catecholamines. Stress was shown to increase intestinal permeability to markers such as Cr-EDTA, HRP and dextran 10,000 in rats. In addition, stress increases the permeability of intestinal M-cells. Finally, stress increased the permeability of Paneth cells to HRP. Since Paneth cells synthesize NOD2 mRNA and protein, stress may play a role in the genesis or reactivation of Crohn's disease involving the terminal ileum. Brain-gut interactions via neural, hormonal and cytokine signals can diminish the mucosal protective factors and increase the permeability of luminal antigens into the intestinal epithelial and immune cells. Stress appears to play a key role in exacerbating and accentuating the intestinal inflammation in IBD through brain-gut interactions.
3
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Plasma histamine and tumour necrosis factor-alpha levels in Crohn's disease and ulcerative colitis at various stages of disease

100%
Hagel A. F., De Rossi T., Konturek P. C., Albrecht H., Walker S., Hahn E. G., Raithel M.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 4
4
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Serum neutrophil gelatinase-associated lipocalin (NGAL) correlates with clinical and endoscopic activity in ulcerative colitis but fails to predict activity in Crohn's disease

100%
Budzynska A., Gawron-Kiszka M., Nowakowska-Dulawa E., Spiewak J., Lesinska M., Kukla M., Waluga M., Hartleb M.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 6
5
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Clinical significance of urinary glycosaminoglycan excretion in inflammatory bowel disease patients

100%
Derkacz A., Olczyk P., Jura-Poltorak A., Waluga-Kozlowska E., Olczyk K., Komosinska-Vassev K.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 6
6
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Inflammatory bowel disease - Polish contribution

100%
Bartnik W.
Journal of Physiology and Pharmacology. Supplement
|
2003
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tom 54
|
nr 3
205-210
The term "inflammatory bowel disease" includes ulcerative colitis, Lesniowski-Crohn’s disease and indeterminate colitis. The history of these diseases in Poland began with Antoni Lesniowski, who in 1904 described an inflammatory tumour of the small intestine with a fistula to ascending colon. The first contemporary clinical descriptions of the main forms of inflammatory bowel disease emerged after 1960, and were made by Warsaw groups and a surgical group from Poznan. The major contributions of Polish investigators to the development of knowledge about ulcerative colitis and Lesniowski-Crohn’s disease were made in the fields of immunology and genetics and in studies on kallikrein-kinin and haemostasis systems. The investigators of pathogenetic mechanisms in these diseases come from departments of gastroenterology in Warsaw, Lublin, Gdansk and Sosnowiec.
7
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Dual role of endogenous nitric oxide in development of dextran sulfate sodium-induced colitis in rats

100%
Rumi G., Tsubouchi R., Nishio H., Kato S., Mozsik G., Takeuchi K.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 4
The role of nitric oxide (NO) in the etiology of ulcerative colitis is controversial with reports of the improvement and aggravation of colonic lesions by inducible NO synthase (iNOS) inhibitors. In the present study, we compared the effect of the selective iNOS inhibitor aminoguanidine and the nonselective NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on a dextran sulfate sodium (DSS)-induced model of colitis in rats. Experimental colitis was induced by a 3% DSS-solution added to drinking water for 7 days. Aminoguanidine (5~20 mg/kg) and L-NAME (10 mg/kg) were administered p.o. twice daily for the first 3 days, the last 3 days or all 6 days of DSS treatment. Body weight and severity of colitis (diarrhea, bloody feces) were observed over a period of 7 days. DSS treatment resulted in severe colonic lesions, accompanied by diarrhea, bloody feces, decrease of body weight and colon shortening. All of the parameters investigated improved significantly with aminoguanidine treatment at 20 mg/kg for 6 days or the last 3 days of DSS-treatment, but L-NAME did not significantly affect the colitis during these periods. When L-NAME or aminoguanidine was given in the first 3 days of DSS treatment, the colonic lesions were slightly aggravated by L-NAME but not affected by aminoguanidine. The expression of iNOS mRNA was observed from the 3rd day of DSS treatment. These results suggested that endogenous NO exerts a biphasic influence on DSS-induced colitis, depending on the NOS isoenzyme; a beneficial effect of NO derived from constitutive NOS and a detrimental effect of NO produced by iNOS in the development of colitis.
8

Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis

84%
Drzymala-Czyz S., Banasiewicz T., Tubacka M., Tarasiuk-Rusek A., Majewski P., Drews M., Walkowiak J.
Folia Histochemica et Cytobiologica
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2012
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tom 50
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nr 1
9
Content available remote

Serum galectin 3, galectin 9 and galectin 3-binding proteins in patients with active and inactive inflammatory bowel disease

84%
Cibor D., Szczeklik K., Brzozowski B., Mach T., Owczarek D.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 1
10

Hospitalization frequency caused by inflammatory bowel disease in rural and urban inhabitants

84%
Cichoz-Lach H., Celinski K., Slomka M.
Polish Journal of Environmental Studies
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2010
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tom 19
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nr 5
The purpose of our study was to analyze hospitalizations for inflammatory bowel disease noted in the Department of Gastroenterology, Medical University of Lublin. Cases of patients hospitalized in the Department of Gastroenterology, Medical University of Lublin in 1997-2007 were retrospectively analyzed. The material studied included patients’ case histories and medical records that were used to select such patients whose hospitalizations were caused by ulcerative colitis and Crohn’s disease. Analysis distinguished two groups: rural and urban inhabitants. In 1997-2007 there were 1,825 hospitalizations for the inflammatory bowel disease noted at our clinic, which was 12.15% of all hospitalizations: 8.54% patients with ulcerative colitis and 3.61% with Crohn’s disease. Among them, 30.47% were rural inhabitants while 69.53% of patients lived in towns. The observation data demonstrated that there has been a significant increase of patients with inflammatory bowel disease in the last decade, and the patients originating in urban areas were more frequent than those from rural regions. This may be related to environmental differences between these two population groups.
11
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Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability

84%
Klicek R., Kolenc D., Suran J., Drmic D., Brcic L., Aralica G., Sever M., Holjevac J., Radic B., Turudic T., Kokot A., Patrij L., Rucman R., Seiwerth S., Sikiric P.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 5
12
Content available remote

Comparison of anti-inflammatory properties of peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone in prophylactic treatment of experimental colitis

84%
Celinski K., Dworzanski T., Fornal R., Korolczuk A., Madro A., Brzozowski T., Slomka M.
Journal of Physiology and Pharmacology
|
2013
|
tom 64
|
nr 5
13
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Probiotics in the treatment of gastrointestinal diseases

84%
Przerwa F., Kukowka A., Kotrych K., Uzar I.
Herba Polonica
|
2021
|
tom 67
|
nr 2
14

Clinical parameters of inflammatory bowel disease in children do not correlate with four common polymorphisms of the transforming growth factor beta1 gene

84%
Liberek A., Jakobkiewicz-Banecka J., Kloska A., Swiderska J., Kmiec Z., Luczak G., Wierzbicki P., Liberek T., Marek K., Plata-Nazar K., Sikorska-Wisniewska G., Kaminska B., Wegrzyn G.
Acta Biochimica Polonica
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2011
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tom 58
|
nr 4
Transforming growth factor β1 (TGF-β1) is a cytokine affecting cell proliferation and development, which also has an immunomodulatory activity. Correlations between polymorphisms of the TGF-β1 gene and clinical parameters of inflammatory bowel disease (IBD) were reported previously in adults. Here, we tested whether such correlations occur in pediatric patients suffering from IBD. One hundred and four pediatric IBD patients were involved in this study. Among them, 36 were diagnosed with Crohn's Disease (CD) and 68 were diagnosed with ulcerative colitis (UC). The control group consisted of 103 children, in which IBD was excluded. TGF-β1 levels were determined in plasma and intestinal mucosa samples. The presence of the TGF β1 protein and the amount of TGF β1 mRNA were estimated in intestinal mucosa by immunohistochemistry and reverse transcription Real-Time PCR, respectively. Four common polymorphisms of the TGF-β1 gene were investigated: -800G/A, -509C/T, 869T/C and 915G/C. No significant correlation between TGF-β1 genotypes and (i) TGF-β1 levels in plasma and tissue samples, (ii) TGF-β1 gene expression efficiency in intestinal mucosa, (iii) IBD clinical parameters and (iv) inflammatory activity could be detected in children suffering from IBD. We conclude that, contrary to previous suggestions, the four common polymorphisms of the TGF-β1 gene do not influence the susceptibility to or clinical parameters of IBD in the tested population of children.
15

Innate lymphoid cells in inflammatory bowel disease

84%
Li J., Glover S. C.
Archivum Immunologiae et Therapiae Experimentalis
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2018
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tom 66
|
nr 6
16

Specific T-cell subsets can predict the efficacy of anti-TNF treatment in inflammatory bowel diseases

84%
Dulic S., Toldi G., Sava F., Kovacs L., Molnar T., Milassin A., Farkas K., Rutka M., Balog A.
Archivum Immunologiae et Therapiae Experimentalis
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2020
|
tom 68
|
nr 2
17

Inulin supplementation in rat model of pouchitis

84%
Drzymala-Czyz S., Banasiewicz T., Tubacka M., Majewski P., Biczysko M., Koscinski T., Drews M., Walkowiak J.
Acta Biochimica Polonica
|
2011
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tom 58
|
nr 3
Available data indicates potential effectiveness of prebiotic therapy in alleviating inflammation and prolonging the remission in inflammatory bowel disease. Documented successes of such therapies were the basis for this study. So far, there is no data related to the effectiveness of inulin application in symptomatic or severe pouchitis in humans or in animal model. The aim of the study was to determine the effect of inulin supplementation on the expression of intestinal inflammation and feeding efficiency in rats with induced pouchitis. Twenty-four Wistar rats were operated. After induction of pouchitis animals were randomly divided into control and supplementation groups receiving, respectively, semi-synthetic diet with or without inulin (in a lower (LD) or higher (HD) dose: 2.5 % or 5 % of total dietary content of mass) for a period of 6 weeks. Selected nutritional parameters were assessed throughout the study. Histopathological and immunohistochemical analysis of pouch mucosa specimens was also performed. The energy intake, weight gain, feeding efficiency, quality of stools were comparable in all studied groups. The intensity of inflammation (Moskovitz scale) and adaptive changes (Laumonier scale) did not differ between compared groups. The tissue expression of pro- and anti-inflammatory interleukins (IL-1α, IL-6, IL-10 and IL-12) was not different either. Inulin supplementation does not improve the quality of stools or the expression of intestinal inflammation in rats with induced pouchitis. It has no impact on the intensity of pouch adaptation or on feeding efficiency.
18
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A mutein of human basic fibroblast growth factor TGP-580 accelerates colonic ulcer healing by stimulating angiogenesis in the ulcer bed in rats

84%
Satoh H., Szabo S.
Journal of Physiology and Pharmacology
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2015
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tom 66
|
nr 5
19
Content available remote

Exploring novel colon-targeting antihistaminic prodrug for colitis

84%
Dhaneshwar S., Gautam H.
Journal of Physiology and Pharmacology
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2012
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tom 63
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nr 4
20
Content available remote

Clinical usefulness of probiotics in inflammatory bowel diseases

84%
Mach T.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 9
23-33
Probiotics are live nonpathogenic bacteria or bacterial components that may be helpful in the prevention and treatment of acute diarrhoea in adults and children and have some effects on the course of inflammatory bowel diseases (IBD). Many experimental and clinical studies suggest that intestinal bacterial flora plays an important role in the pathogenesis of IBD, and manipulation of the luminal contents with antibiotics or probiotics represents a potentially effective therapeutic option. The beneficial effect of probiotics was demonstrated mainly in the prevention and treatment of pouchitis and in maintaining remission of mild to moderate ulcerative colitis. Probiotics seems to be less effective in patients with Crohn’s disease. Randomized clinical trials are still required to further define the role of probiotics as preventive and therapeutic agents. This review summarizes the current data about probiotics in IBD.
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