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Crosstalk between autophagy and proteasome protein degradation systems: possible implications for cancer therapy

100%

Wojcik S.

Folia Histochemica et Cytobiologica

2013

tom 51

nr 4

Semispecific TPPII inhibitor Ala-Ala-Phe-chloromethylketone (AAF-cmk) displays cytotoxic activity by induction of apoptosis, autophagy and protein aggregation in U937 cells

100%

Bialy L. P., Fayet J., Wilczynski G. M., Mlynarczuk-Bialy I.

Folia Histochemica et Cytobiologica

2018

tom 56

nr 4

Role of ubiquitin ligases in neural stem and progenitor cells

100%

Naujokat C.

Archivum Immunologiae et Therapiae Experimentalis

2009

tom 57

nr 3

177-188

The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research

80%

Ostrowska H.

Cellular and Molecular Biology Letters

2008

tom 13

nr 3

353-365

The ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins, including those that control cell cycle progression, apoptosis, signal transduction and the NF-κB transcriptional pathway. Aberrations in the ubiquitin-proteasome system underlie the pathogenesis of many human diseases, so both the ubiquitin-conjugating system and the 20S proteasome are important targets for drug discovery. This article presents a few of the most important examples of the small molecule inhibitors and modulators targeting the ubiquitin-proteasome system, their mode of action, and their potential therapeutic relevance in the treatment of cancer and inflammatory-related diseases.

Ograniczanie wyników

2 Folia Histochemica et Cytobiologica

1 Archivum Immunologiae et Therapiae Experimentalis

1 Cellular and Molecular Biology Letters

1 Bialy L. P.

1 Fayet J.

1 Mlynarczuk-Bialy I.

1 Naujokat C.

1 Ostrowska H.

1 Wilczynski G. M.

1 Wojcik S.

1 2018

1 2013

1 2009

1 2008

Wyniki wyszukiwania

Crosstalk between autophagy and proteasome protein degradation systems: possible implications for cancer therapy

Semispecific TPPII inhibitor Ala-Ala-Phe-chloromethylketone (AAF-cmk) displays cytotoxic activity by induction of apoptosis, autophagy and protein aggregation in U937 cells

Role of ubiquitin ligases in neural stem and progenitor cells

The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research