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  1. 12 Folia Histochemica et Cytobiologica

  2. 5 Journal of Physiology and Pharmacology

  3. 4 Polish Journal of Veterinary Sciences

  4. 3 Cellular and Molecular Biology Letters

  5. 2 Acta Neurobiologiae Experimentalis

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Autorzy help

  1. 8 Lakomy M.

  2. 7 Kaleczyc J.

  3. 7 Majewski M.

  4. 7 Wasowicz K.

  5. 4 Goc A.

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  1. 1 2021

  2. 1 2020

  3. 2 2017

  4. 1 2015

  5. 1 2014

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1

M-SAR properties of bovine DNA enclosing the tyrosine hydroxylase gene

100%
Lenartowski R., Grzybowski T., Miscicka-Sliwka D., Goc A.
Cellular and Molecular Biology Letters
|
2000
|
tom 05
|
nr 2
2

Tissue specific interactions of the nuclear proteins with the bovine tyrosine hydroxylase gene

100%
Lenartowski R., Pluskota W., Wojciechowski W., Goc A.
Cellular and Molecular Biology Letters
|
1997
|
tom 02
|
nr 2
3

Immunocytochemical localization of tyrosine hydroxylase in the visual cortex of the microbat, Rhinolophus ferrumequinum

88%
Lee M.-J., Kwon K.-M., Lee W.-T., Kim G.-H., Jeon C.-J.
Folia Histochemica et Cytobiologica
|
2020
|
tom 58
|
nr 2
4

The bovine tyrosine hydroxylase gene associates in vitro with the nuclear matrix by its first intron sequence

88%
Lenartowski R., Grzybowski T., Miscicka-Sliwka D., Wojciechowski W., Goc A.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr 3
Recently we have shown that in vitro binding of the proximal part of the human tyro­sine hydroxylase gene to the nuclear matrix is correlated with its transcriptional activ­ity. The strongest binding potential was predicted by computing for the first intron se­quence (Lenartowski & Goc, 2002, Neurosci Lett.; 330: 151-154). In this study a 16 kb fragment of the bovine genomic DNA containing the tyrosine hydroxylase gene was investigated for its affinity to the nuclear matrix. Only a 950 bp fragment encod­ing the distal part of the first intron, second exon and a few nucleotides of the second intron bound to the nuclear matrix. The binding was independent of the tissue-specific tyrosine hydroxylase gene activation. The fragment was subcloned and sequenced. Computer search pointed to one potential intronic matrix attachment region with two AP1-like sites embedded in the sequence. We conclude that even if the position of the matrix binding region is conserved among the tyrosine hydroxylase genes in mam­mals, its tissue specificity and/or function is not preserved or is achieved by different mechanisms.
5

Proximal part of human tyrosine hydroxylase gene binds nuclear matrix in tissue specific manner

75%
Lenartowski R., Goc A.
Cellular and Molecular Biology Letters
|
2000
|
tom 05
|
nr 2
6

The relationships between neurons containing dopamine and nitric oxide synthase in the ventral tegmental area

75%
Klejbor I., Domaradzka-Pytel B., Ludkiewicz B., Wojcik S., Morys J.
Folia Histochemica et Cytobiologica
|
2004
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tom 42
|
nr 2
7

Regional differences in the vulnerability of substantia nigra dopaminergic neurons in weaver mice

63%
Marti J., Santa-Cruz M. C., Molina V., Serra R., Bayer S. A., Ghetti B., Hervas J. P.
Acta Neurobiologiae Experimentalis
|
2009
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tom 69
|
nr 2
198-206
Vulnerability of midbrain dopaminergic (DA) neurons in the weaver mouse was studied at postnatal (P) days 8 and 90, in chosen coronal levels throughout the anteroposterior (AP) extent of the substantia nigra pars compacta (SNc). Wild-type (+/+) and homozygous weaver (wv/wv) mice used were the offspring of pregnant dams injected in several cases with tritiated thymidine on embryonic days 11-15. DA neurons were identified for their tyrosine hydroxylase immunoreactivity. Data reveal that at P8, the frequency of both +/+ and wv/wv late-generated DA cells increases from rostral to caudal SNc. No apparent DA-cell loss was observed at P8 in the mutant genotype, irrespective of the AP level considered. However, throughout the AP, there was a significant reduction in the number of these neurons at any level in 90-day-old weavers. Comparison of P8 and P90 +/+ SNc suggests that cell death is not a major aspect in the developmental regulation of normal DA neurons, although numerical cell depletion in the postnatal development of weaver SNc probably results from the amplification of a basal cell-death process, which affected all the coronal levels studied.
8
Content available remote

The alpha2-adrenoceptors do not modify the activity of tyrosine hydroxylase, corticoliberine, and neuropeptide Y producing hypothalamic magnocellular neurons in the Long Evans and Brattleboro rats

63%
Bundzikova J., Pirnik Z., Zelena D., Mikkelsen J. D., Kiss A.
Journal of Physiology and Pharmacology
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2010
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tom 61
|
nr 4
391-398
The hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei are activated by body salt-fluid variations. Stimulation of 2-adrenoceptors by an agonist-xylazine (XYL) activates oxytocinergic but not vasopressinergic magnocellular neurons. In this study, tyrosine hydroxylase (TH), corticoliberine (CRH), and neuropeptide Y (NPY) magnocellular phenotypes, were analysed in response to 2-adrenoceptor manipulations and sustained hyperosmolality in vasopressin deficient homozygous Brattleboro (di/di) rats. Saline (0.9% NaCl, 0.1 ml/100g/bw), XYL (10 mg/kg/bw), atipamezole (ATIP, 2-adrenoceptors antagonist, 1 mg/kg/bw), and ATIP 5 min later followed by XYL, were applied intraperitoneally. Presence of immunolabeled Fos peptide signalized the neuronal activity. Ninety minutes after injections, the rats were anesthesized and sacrificed by transcardial perfusion with fixative. Coronal sections of 30 µm thickness double immunolabeled with Fos/neuropeptide were evaluated under light microscope. Under basal conditions, di/di in comparison with control Long Evans rats, displayed significantly higher number of TH, CRH, and NPY immunoreactive neurons in the SON and PVN (except NPY cells in PVN) and more than 90%, 75%, and 86% of TH, NPY, and CRH neurons, respectively, displayed also Fos signal in the SON. XYL did not further increase the number of Fos in the PVN and SON and ATIP failed to reduce the stimulatory effect of hypertonic saline in all neuronal phenotypes studied. Our data indicate that hyperosmotic conditions significantly influence the activity of TH, CRH, and NPY magnocellular neuronal phenotypes, but 2-adrenoceptors do not play substantial role in their regulation during osmotic challenge induced by AVP deficiency.
9
Content available remote

Citicoline improved cardiovascular function in animal model of dysautonomia

63%
Amin S. N., Khashaba A. S., Latif N. S. A., El Gazzar W. B., Hussein U. K.
Journal of Physiology and Pharmacology
|
2021
|
tom 72
|
nr 1
10

Uterus-innervating neurones of paracervical ganglion in the pig: immunohistochemical characteristics

63%
Wasowicz K., Podlasz P., Czaja K., Lakomy M.
Folia Morphologica
|
2002
|
tom 61
|
nr 1
15-20
Immunohistochemical characteristics of neurones innervating the porcine uterus located in paracervical ganglia were studied with a combination of retrograde fluorescent tracing and immunofluorescence. Retrograde fluorescent tracer Fast Blue (FB) was injected into the uterine horn and uterine cervix. The presence of biologically active substances, tyrosine hydroxylase (TH), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), galanin (GAL), Met-enkephalin-Arg-GlyLeu (MEAGL) and calcitonin gene-related peptide (CGRP) was studied in FBpositive neurones localised in paracervical ganglia. FB-positive neurones containing TH, NPY, VIP and MEAGL were numerous, while those containing CGRP were scarce. The results pointed to some species-related differences in immunohistochemical coding of neurones of paracervical ganglion responsible for uterus innervation.
11
Content available remote

Increased gene expression of catecholamine-synthesizing enzymes in adrenal glands contributes to high circulating catecholamines in pigs with tachycardia-induced cardiomyopathy

63%
Tomaszek A., Kiczak L., Bania J., Paslawska U., Zacharski M., Janiszewski A., Noszczyk-Nowak A., Dziegiel P., Kuropka P., Ponikowski P., Jankowska E. A.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 2
12

Postnatal changes in adrenergic and neuropeptide Y - containing nerve fibres in pineal gland of the pig. An immunohistochemical study

63%
Przybylska-Gornowicz B., Kaleczyc J., Majewski M., Lewczuk B.
Folia Histochemica et Cytobiologica
|
1995
|
tom 33
|
nr 4
13

Occurrence and coexistence of some neuropeptides in nerve fibres supplying the bovine ovary and its extrinsic blood vessels

63%
Kaleczyc J., Majewski M., Lakomy M., Sienkiewicz W.
Folia Histochemica et Cytobiologica
|
1995
|
tom 33
|
nr 3
14

Blockade on NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats

63%
Wedzony K., Fijal K., Chocyk A.
Journal of Physiology and Pharmacology
|
2005
|
tom 56
|
nr 2
Malfunction of glutamatergic neurotransmission in postnatal period is considered to be a risk factor for development of schizophrenia. Thus, the present study investigates the impact of NMDA receptor blockade in the postnatal period on the density of tyrosine hydroxylase immunoreactive axonal arbors in the rat medial prefrontal cortex. Behavioral experiments revealed that adult rats (60 days old) treated in the postnatal period with a competitive antagonist of NMDA receptors, CGP 40116 (1.25 mg/kg on days 1, 3, 6, 9; 2.5 mg/kg on days 12, 15, 18; and finally 5 mg/kg on day 21, all injections s.c.), showed enhancement of the locomotor activity stimulated by quinpirole (0.3 mg/kg s.c.) and amphetamine (0.5 mg/kg s.c.), which suggests development of functional supersensitivity of dopaminergic systems. It has been found that CGP 40116, given in postnatal period decreased the density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult animals. The decrease was observed in superficial (II/III) and deep (V/VI) layers of the medial prefrontal cortex, while the average length of tyrosine hydroxylase immunoreactive axonal arbors was increased in both superficial and deep cortical layers. Changes in the density of tyrosine hydroxylase immunoreactive axonal arbors have not been followed by a significant decrease in the content of tyrosine hydroxylase protein measured by Western blot. Thus, NMDA receptor blockade in the early period of life evokes changes in architecture of tyrosine hydroxylase immunoreactive axonal arbors and that malfunction of glutamatergic neurotransmission, in early period of life may produce anatomical changes which resemble those observed in the brains of schizophrenics.
15

Peptidergic innervation of the porcine oviduct studied by double-labelling immunohistochemistry

63%
Czaja K., Kaleczyc J., Sienkiewicz W., Majewski M., Lakomy M.
Folia Histochemica et Cytobiologica
|
1996
|
tom 34
|
nr 3-4
16

Effect of total or partial uterus extirpation on uterus-projecting neurons in porcine inferior mesenteric ganglion. A. Changes in expression of transmitter-synthesizing enzymes-tyrosine hydroxylase, dopamine beta-hydroxylase and choline acetyltrans

51%
Wasowicz K.
Polish Journal of Veterinary Sciences
|
2003
|
tom 06
|
nr 2
17
Content available remote

Effect of ghrelin receptor agonist and antagonist on the activity of arcuate nucleus tyrosine hydroxylase containing neurons in C57BL/6 male mice exposed to normal or high fat diet

51%
Pirnik Z., Majercikova Z., Holubova M., Pirnik R., Zelezna B., Maletinska L., Kiss A.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 4
18

Immunohistochemical characteristics of neurons in the ganglia of the greater splanchnic nerve of the pig

51%
Nourinezhad J., Podlasz P., Wasowicz K.
Folia Histochemica et Cytobiologica
|
2017
|
tom 55
|
nr 4
19

Changes in the expression of tyrosine hydroxylase [TH], dopamine beta-hydroxylase [DBH], galanin [GAL], vasoactive intestinal polypeptide [VIP] and substance P [SP] in the uterine cervix-projecting neurons located in the lumbar paravertebral ganglia of the pig

51%
Wasowicz K.
Folia Morphologica
|
2003
|
tom 62
|
nr 3
219-221
The uterine cervix-projecting neurons located in the lumbar paravertebral ganglia were identified by retrograde tracing. These contained immunoreactivity to TH and DBH. No immunoreactivity to GAL, VIP and SP was found in the neurons. Extirpation of the uterus reduced the expression of TH and induced the expression of GAL in the neurons. Expression of other substances studied was unchanged.
20

Prefrontal catecholaminergic turnover and antioxidant defense system of chronically stressed rats

51%
Popovic N., Pajovic S. B., Stojiljkovic V., Pejic S., Todorovic A., Pavlovic I., Gavrilovic L.
Folia Biologica
|
2017
|
tom 65
|
nr 1
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