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  1. 6 Folia Histochemica et Cytobiologica

  2. 3 Acta Biochimica Polonica

  3. 3 Archivum Immunologiae et Therapiae Experimentalis

  4. 3 Journal of Physiology and Pharmacology

  5. 1 Acta Scientiarum Polonorum. Medicina Veterinaria

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  1. 2 Madej J. A.

  2. 2 Mroczko B.

  3. 2 Nowak M.

  4. 2 Szmitkowski M.

  5. 1 Antosz H.

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  1. 1 2020

  2. 1 2019

  3. 3 2018

  4. 1 2017

  5. 2 2014

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1

Cyclooxygenase pathways

100%
Korbecki J., Baranowska-Bosiacka I., Gutowska I., Chlubek D.
Acta Biochimica Polonica
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2014
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tom 61
|
nr 4
2

Exogenous nitric oxide inhibits shedding of ADAM17 substrates

100%
Bzowska M., Stalinska K., Mezyk-Kopec R., Wawro K., Duda K., Das S., Bereta J.
Acta Biochimica Polonica
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2009
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tom 56
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nr 2
325-335
 Both ADAM17, the secretase responsible for the shedding of ectodomains of numerous membrane proteins including TNF and its receptors, as well as nitric oxide synthesized by inducible nitric oxide synthase play regulatory roles in inflammation and tumor progression. We analyzed the effect of endogenous and exogenous nitric oxide on the expression and activity of ADAM17 in murine endothelial cells and a monocyte/macrophage cell line. We found that endogenous nitric oxide influenced neither ADAM17 mRNA level nor the shedding of two ADAM17 substrates, TNF and TNFR1. Exogenous NO significantly diminished the release of TNF and TNFR1 without affecting the ADAM17 transcript level. Our data seem contrary to a previous report that showed the activation of ADAM17 by nitric oxide (Zhang et al., 2000, J Biol Chem 275: 15839-15844). We discuss potential mechanisms of NO-mediated inhibition of ectodomain shedding and possible reasons of discrepancy between our results and the previous report.
3

Myeloid-derived suppressor cells in the tumor microenvironment: current knowledge and future perspectives

100%
Ibanez-Vea M., Zuazo M., Gato M., Arasanz H., Fernandez-Hinojal G., Escors D., Kochan G.
Archivum Immunologiae et Therapiae Experimentalis
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2018
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tom 66
|
nr 2
4

Radiofrequency ablation does not induce the significant increase of CD4+CD25+Foxp3+ regulatory T cells compared with surgical resection in Hepa 1-6 tumor model

100%
Gao H.-J., Zhang Y.-J., Liang H.-H., Li P., Peng Z.-W., Pang X.-H., Chen M.-S.
Archivum Immunologiae et Therapiae Experimentalis
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2013
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tom 61
|
nr 4
5

Leukocytes function in the course of tumour progression in a rat model

100%
Graczyk S., Madej J. A., Pliszczak-Krol A., Nowak M., Janaczyk B.
Acta Scientiarum Polonorum. Medicina Veterinaria
|
2004
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tom 03
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nr 1
6
Content available remote

Differential effects of nitric oxide deficiency on primary tumour growth, pulmonary metastasis and prostacyclin/thromboxane A2 balance in orthotopic and intravenous murine models of 4T1 breast cancer

84%
Kij A., Kus K., Smeda M., Zakrzewska A., Proniewski B., Matyjaszczyk K., Jasztal A., Stojak M., Walczak M., Chlopicki S.
Journal of Physiology and Pharmacology
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2018
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tom 69
|
nr 6
7

Functions of cancer-derived extracellular vesicles in immunosuppression

84%
Czernek L., Duchler M.
Archivum Immunologiae et Therapiae Experimentalis
|
2017
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tom 65
|
nr 4
8
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Content available

Recent advances in the role of AMP-activated protein kinase in metabolic reprogramming of metastatic cancer cells: targeting cellular bioenergetics and biosynthetic pathways for anti-tumor treatment

84%
Tyszka-Czochara M., Konieczny P., Majka M.
Journal of Physiology and Pharmacology
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2018
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tom 69
|
nr 3
9

Tumor models for prostate cancer exemplified by fibroblast growth factor 8-induced tumorigenesis and tumor progression

84%
Tuomela J., Harkonen P.
Reproductive Biology
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2014
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tom 14
|
nr 1
10

Potential role of macrophage migration inhibitory factor in the pathogenesis of Marek’s disease

84%
Fan Z., Wang H., Pan J., Yu S., Xia W.
Journal of Veterinary Research
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2020
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tom 64
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nr 1
11
Content available remote

Heparanase link between vasculogenesis and angiogenesis as well as a predictive factor of a shorter survival rate

84%
Bielawski K., Rhone P., Bielawska S., Rosc D., Brkic A., Zarychta E., Ruszkowska-Ciastek B.
Journal of Physiology and Pharmacology
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2019
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tom 70
|
nr 3
12

Expression of E-cadherin, beta-catenin and Ki-67 antigen and their reciprocal relationships in mammary adenocarcinomas in bitches

84%
Nowak M., Madej J. A., Dziegiel P.
Folia Histochemica et Cytobiologica
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2007
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tom 45
|
nr 3
13

Expression of CD44 on two lines of transplantable melanoma cells - relationship with cytokine secretion and tumor progression

84%
Kozlowska K., Cichorek M., Zarzeczna M., Wojcik S.
Folia Histochemica et Cytobiologica
|
2004
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tom 42
|
nr 1
14

The role of cell adhesion molecule in cancer progression and its application in cancer therapy

84%
Okegawa T., Pong R. C., Li Y., Hsieh J. T.
Acta Biochimica Polonica
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2004
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tom 51
|
nr 2
Multiple and diverse cell adhesion molecules take part in intercellular and cell-extracellular matrix interactions of cancer. Cancer progression is a multi-step process in which some adhesion molecules play a pivotal role in the development of recurrent, invasive, and distant metastasis. A growing body of evidence indicates that alterations in the adhesion properties of neoplastic cells play a pivotal role in the development and progression of cancer. Loss of intercellular adhesion and the des­quamation of cells from the underlying lamina propria allows malignant cells to es­cape from their site of origin, degrade the extracellular matrix, acquire a more motile and invasion phenotype, and finally, invade and metastasize. In addition to partici­pating in tumor invasiveness and metastasis, adhesion molecules regulate or signifi­cantly contribute to a variety of functions including signal transduction, cell growth, differentiation, site-specific gene expression, morphogenesis, immunologic function, cell motility, wound healing, and inflammation. Cell adhesion molecule (CAM), a di­verse system of transmembrane glycoproteins has been identified that mediates the cell–cell and cell–extracellular matrix adhesion and also serves as the receptor for different kinds of virus. We summarize recent progress regarding the role of CAM, particularly, immunoglobulin-CAMs and cadherins in the progression of cancer and discuss the potential application of CAMs in the development of cancer therapy mainly on urogenital cancer.
15

The relationships between hypoxia-dependent markers: HIF-1alpha, EPO and EPOR in colorectal cancer

67%
Baltaziak M., Wincewicz A., Kanczuga-Koda L., Lotowska J. M., Koda M., Sulkowska U., Baltaziak M., Podbielska M., Sobaniec-Lotowska M. E., Sulkowski S.
Folia Histochemica et Cytobiologica
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2013
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tom 51
|
nr 4
16

Cloning of the human activated leukocyte cell adhesion molecule promoter and identification of its tissue-independent transcriptional activation by Sp1

67%
Tan F., Mbunkui F., Ofori-Acquah S. F.
Cellular and Molecular Biology Letters
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2012
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tom 17
|
nr 4
Activated leukocyte cell adhesion molecule (ALCAM) belongs to the immunoglobulin cell adhesion molecule super family. ALCAM is implicated in tumor progression, inflammation, and the differentiation of hematopoietic stem cells. Hitherto, the identity of regulatory DNA elements and cognate transcription factors responsible for ALCAM gene expression remained unknown. In this report, the human ALCAM promoter was cloned and its transcriptional mechanisms elucidated. The promoter is TATA-less and contains multiple GC-boxes. A proximal 650-bp promoter fragment conferred tissue-independent activation, whereas two contiguous regions upstream of this region negatively influenced promoter activity in a tissue-specific manner. The positive regulatory promoter region was mapped to a core 50 base pair sequence containing a conical Sp1 element. Mutation analysis revealed that this element alone or in tandem with elements immediately upstream was required for maximal promoter activity. Chromatin analysis revealed that Sp1 binds exclusively to the canonical binding sequence in vivo, but not to DNA sequence immediately upstream. Finally, we showed that over-expression of Sp1 significantly increased the basal promoter activity. Thus, Sp1 activated the ALCAM promoter in most cells. These findings have important ramifications for unraveling the roles of ALCAM in inflammation and tumorigenesis.
17

The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer

67%
Groblewska M., Siewko M., Mroczko B., Szmitkowski M.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 1
18

Clinical significance of serum levels of matrix metalloproteinase 2 (MMP-2) and its tissue inhibitor (TIMP-2) in gastric cancer

67%
Mroczko B., Lukaszewicz-Zajac M., Gryko M., Kedra B., Szmitkowski M.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 1
19

Alterations in TP53, cyclin D2, c-Myc, p21WAF1/CIP1 and p27KIP1 expression associated with progression in B-CLL

67%
Antosz H., Paterski A., Marzec-Kotarska B., Sajewicz J., Dmoszynska A.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 4
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