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Principles of trichinellosis treatment were presented, based on contemporary parasitologic and clinical criteria. Significance of the Trichinella sp. life cycle, phase of the invasion and the disease was presented. The role of anthelmintics was stressed, as drugs of choice in eradication of the intestinal phase and in prevention against development of the muscular phase. Role of glucocorticoids was described in suppression of acute clinical signs/symptoms. Pathology of the late period of trichinellosis and of the late invasion sequele were discussed.
Malaria is one of the most devastating diseases of tropical countries with clinical manifestations such as anaemia, splenomegaly, thrombocytopenia, hepatomegaly and acute renal failures. In this study, cases of thrombocytopenia and haemoglobinemia were more prominent in subjects infected with Plasmodium falciparum (Welch, 1897) than those with Plasmodium vivax (Grassi et Feletti, 1890). However, anaemia, jaundice, convulsions and acute renal failure were significantly high (3–4 times) in subjects infected with P. falciparum than those infected with P. vivax. The incidence of splenomegaly and neurological sequelae were 2 and 6 times higher in P. falciparum infections compared to the infections of P. vivax. Both in P. vivax and P. falciparum malaria, the cases of splenomegaly, jaundice and neurological sequelae were almost double in children (<10 years) compared to older patients. The liver enzymes were generally in normal range in cases of low and mild infections. However, the AST, ALT, ALP activities and serum bilirubin, creatinine, and the urea content were increased in P. falciparum and P. vivax malaria patients having high parasitaemia, confirming liver dysfunction and renal failures in few cases of severe malaria both in India and Saudi Arabia.
An enzyme-histochemical study of five enzymes, namely succinate dehydrogenase (SDH), lactate dehydrogenase (LDH), cytochrome oxidase (CCO), cholinesterase (CHE) and nitric oxide synthase (NOS), was elucidated in the soft tissues of Oncomelania hupensis, the intermediate host snail of Schistosoma japonicum, before and after the treatment with a suspension concentrate of niclosamide (SCN). Following the treatment of SCN, a marked loss occurred in the activity of the five enzymes mentioned above. LDH and SDH showed their strongest activity in the buccal mass and muscular fibers, CCO in buccal mass and liver, CHE in pellicle and ganglia, and NOS in muscular fibers and pharyngeal canal. The results indicate that SCN impairs the activities of the enzymes influencing the transfer of neurotransmitter and energy supply in O. hupensis, ultimately leading to the loss of various physiological functions, which is considered to be a cause of death in O. hupensis.
Aspects of human infection with Onchocerca volvulus was investigated in 9 villages in Okigwe LGA of Imo State, Nigeria between January 2010 and December 2011. The objectives were to compare the prevalence of different manifestations of Onchocerciasis according to gender and age, with view to determine if there had been a change in prevalence of Onchocerciasis among residents of some communities in Okigwe Local Government Area of Imo State. A cross sectional survey method was adopted for the study, blood free skin snips were collected from randomly selected consenting adults aged 5-62 years. Palpation for mobile subcutaneous lumps and clinical manifestation were observed among 960 persons comprising 511 males and 449 females. The commonest lesions observed were poor vision 17 %, nodules 15 %, leopard skin 20 %, lizard skin 15 %, and hanging groin 3 %. Musculo-skeletal pain (MSP) was recorded as one of the major complaints by 30 % of the subjects. The result showed that Onchocerciasis clinical manifestations are still prevalent, however nodules prevalence reduced among the sampled population (69.8 %).
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