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Acid and neutral lipase activity in lymphocytes of patients with increased serum cholesterol and triglyceride level

100%

Miszczuk-Jamska B., Chevalier F., Maire I., Dembinska-Kiec A.

Journal of Physiology and Pharmacology

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1993

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tom 44

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nr 4

2

The common adiponutrin variant p.I148M does not confer gallstone risk but affects fasting glucose and triglyceride levels

84%

Krawczyk M., Gruenhage F., Mahler M., Tirziu S., Acalovschi M., Lammert F.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 3

Recently the common adiponutrin (PNPLA3) polymorphism p.I148M has been identified as a genetic determinant of severe forms of non-alcoholic fatty liver disease and alcoholic liver disease. Additionally, insulin resistance - linked to the development of non-alcoholic steatohepatitis - increases the risk of developing gallstones. Here we assessed whether the PNPLA3 p.I148M (c.444 C>G) polymorphism affects glucose and lipid levels and increases gallstone risk. We analysed 229 individuals with gallstones from 108 families (age 24-80 years, BMI 17-55 kg/m2) and 258 gallstone-free controls (age 20-70 years, BMI 14-43 kg/m2). Fasting glucose, triglyceride and cholesterol serum levels were determined. The p.I148M polymorphism was genotyped using a PCR-based assay with 5'-nuclease and fluorescence detection. Case-control association tests and nonparametric linkage (NPL) analysis in sib-pairs were performed. Individuals carrying the [GG] genotype had significantly (P<0.0001) higher median fasting glucose levels as compared to [GC] and [CC] carriers. After adjustment for multiple testing, we detected a trend for an association between triglyceride levels and variant adiponutrin in gallstone patients (P=0.032), and gallstone cases carrying the genotype [CC] presented with significantly higher triglyceride levels than the corresponding controls (P<0.003). No significant effects on cholesterol metabolism were detected. Neither genotype distributions nor NPL scores provided evidence for association or linkage between the PNPLA3 variant and gallstones. In conclusion, homozygous carriers of the PNPLA3 risk allele display higher fasting glucose. Although this adiponutrin variant may affect triglyceride homeostasis, it does not increase the risk of cholelithiasis.

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Predisposing factors for puerperal metritis in cows

84%

Markiewicz H., Kuzma K., Malinowski E.

Bulletin of the Veterinary Institute in Puławy

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2001

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tom 45

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nr 2

The investigation was performed on 90 multiparous cows in four farms. Animals were almost identically fed and had similar milk yield during last year (6000 kg milk). Blood samples were taken 3 times (-3, -2, -1 week) before and 2 times (+1, +3 week) after parturition. Some biochemical parameters were determined. In all farms the increase of free fatty acids level was observed after parturition. The decrease in cholesterol concentration and triglyceride level after calving were accompanied. Differences in valucs of analysed parameters (AST, FFA, glucose) in cows with correct and disturbed post partum period were observed before parturition.

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Impact of different maintenance conditions on the lipid profile parameters at fox - Alopex lagopus

67%

Nowakowicz-Debek B., Saba L., Bis-Wencel H., Bombik E.

Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica

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2005

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tom 23

239-244

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Some blood biochemical changes in response to saline exposure in the fresh water fish, Notopterus notopterus (Pallas)

67%

Kavya K. S., Kulkarni R. S., Jadesh M.

International Letters of Natural Sciences

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2015

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tom 49

The changes in some blood biochemical parameters were studied in the freshwater fish N. notopterus under saline exposure for a longer period of 30 days. The blood biochemical parameters are glucose, protein, triglycerides and cholesterol. All these parameters exhibited increased level except of blood glucose which remained unchanged as observed after the termination of saline exposure. Thus it indicates that although fish survives and able to tolerate extreme saline condition as there was no mortality during the exposure period. The increase of blood biochemical parameters can be considered as a kind of saline stress response particularly on lipid derivatives.

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Relation between fractional excretion of uric acid and fasting serum glucose in male children

67%

Messina E., Giacomello A.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

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Mouse models of experimental atherosclerosis

67%

Jawien J., Nastalek P., Korbut R.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 3

Since 1992 the mouse has become an excellent model for experimental atherosclerosis research. Until 1992, the diet - induced atherosclerosis mouse model has been used effectively, but the lesions tended to be small and were limited to early fatty-streak stage. This model was also criticized because of the toxicity and inflammatory responses due to the diet. In 1992 the first line of gene targeted animal models, namely apolipoprotein E - knockout mice was developed. Of the genetically engineered models, the apoE - deficient model is the only one that develops extensive atherosclerotic lesions on a chow diet. It is also the model in which the lesions have been characterized most thoroughly. The lesions develop into fibrous plaques; however, there is no evidence that plaque rupture occurs in this model. The LDL receptor - deficient model has elevated LDL levels, but no lesions, or only very small lesions, form on the chow diet, however, robust lesions do form on the western-type diet. The creation of apoE - knockout mice has changed the face of atherosclerosis research.

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Wplyw krotkotrwalego glodu zupelnego na zachowanie sie niektorych wskaznikow biochemicznych oraz zdolnosc redukcji blekitu tetrazoliowego przez heterofile krwi kurczat-brojlerow

43%

Jakubowski K., Zielinski H., Jedlinska-Krakowska M.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

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1996

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tom 24

155-162

Badania przeprowadzono na 46 brojlerach (kurczętach), w wieku 10 tygodni o przeciętnej masie ciała 2.1 kg (±0.25 kg), podzielonych na 4 grupy (1 kontrolna i 3 doświadczalne). Kurczęta z grup doświadczalnych pozbawiano dostępu do paszy przez okres 24 godzin (grupa 2), 48 godzin (grupa 3) i 72 godzin (grupa 4). Po okresie głodzenia brojlery poddawano ubojowi, w czasie którego pobierano krew do oznaczeń. We krwi pełnej metodą spektrofotometryczną określano zdolność heterofili do redukcji błękitu nitrotetrazoliowego (test NBT), a w plazmie krwi za pomocą ogólnie przyjętych metod oznaczano poziom kortykosteronu, cholesterolu, trójglicerydów, lipidów całkowitych i glukozy. Obliczono również względne procentowe obniżenie masy ciała kurcząt po okresie głodzenia. Wyniki badań poddano analizie statystycznej za pomocą testu t-Studenta. Stwierdzono: - u kurcząt głodzonych przez 24 godziny obniżenie masy ciała o 3.5%, podwyższenie aktywności heterofili, podwyższenie poziomu kortykosteronu oraz obniżenie poziomu trójglicerydów; - u kurcząt głodzonych przez 48 godzin obniżenie masy ciała o 7.3%, podwyższenie aktywności heterofili oraz podwyższenie poziomu kortykosteronu i glukozy; u kurcząt głodzonych przez 72 godziny obniżenie masy ciała o 12.7%, podwyższenie aktywności heterofili, podwyższenie poziomu kortykosteronu i cholesterolu, a obniżenie poziomu trójglicerydów i glukozy.

Ograniczanie wyników

Acid and neutral lipase activity in lymphocytes of patients with increased serum cholesterol and triglyceride level

The common adiponutrin variant p.I148M does not confer gallstone risk but affects fasting glucose and triglyceride levels

Predisposing factors for puerperal metritis in cows

Impact of different maintenance conditions on the lipid profile parameters at fox - Alopex lagopus

Some blood biochemical changes in response to saline exposure in the fresh water fish, Notopterus notopterus (Pallas)

Relation between fractional excretion of uric acid and fasting serum glucose in male children

Mouse models of experimental atherosclerosis

Wplyw krotkotrwalego glodu zupelnego na zachowanie sie niektorych wskaznikow biochemicznych oraz zdolnosc redukcji blekitu tetrazoliowego przez heterofile krwi kurczat-brojlerow