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  1. 16 Archivum Immunologiae et Therapiae Experimentalis

  2. 11 Folia Histochemica et Cytobiologica

  3. 11 Journal of Physiology and Pharmacology

  4. 6 Cellular and Molecular Biology Letters

  5. 2 Acta Biochimica Polonica

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  1. 3 Domagala-Kulawik J.

  2. 3 Stelmaszczyk-Emmel A.

  3. 2 Bocian K.

  4. 2 Brys M.

  5. 2 Drela N.

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  1. 5 2020

  2. 2 2019

  3. 2 2018

  4. 3 2017

  5. 1 2016

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1

Signal transduction in human pancreatic cancer: roles of transforming growth factor beta, somatostatin receptors, and other signal intermediates

100%
Li M., Becnel L. S., Li W., Fisher W. E., Chen C., Yao Q.
Archivum Immunologiae et Therapiae Experimentalis
|
2005
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tom 53
|
nr 5
2

ALK 5 [TGF beta RI] inhibitors: In-vitro and in-vivo characterization of novel orally active pteridines

100%
Chakravarty S., Dugar S.
Cellular and Molecular Biology Letters
|
2005
|
tom 10
|
nr Suppl.2
3

Inhibition of CYP17 expression by adrenal androgenes and transforming growth factor-beta in adrenocortical cells

100%
Biernacka-Lukanty J. M., Lehmann T. P., Trzeciak W. H.
Acta Biochimica Polonica
|
2004
|
tom 51
|
nr 4
Cytochrome P450c17, encoded by the CYP17 gene, is a component of the 17a-hy- droxylase/17,20-lyase enzyme complex essential for production of adrenal gluco­corticoids and androgens as well as gonadal androgens. The expression of CYP17 in adrenocortical cells is stimulated by corticotropin (ACTH) via the signal trans­duction pathway involving cAMP and protein kinase A (PKA). Thus, in addition to glucocorticoids, ACTH stimulates formation of adrenal androgens, which are known to induce transforming growth factor 3 (TGF-3) secretion. TGF-3 in turn inhibits ste­roid hormone output by attenuating both basal and ACTH-dependent expression of CYP17. The present study revealed that treatment of bovine and human H295R adrenocortical cells with androgens resulted in a decrease in the basal level of CYP17 transcript and cortisol secretion, without affecting forskolin-stimulated lev­els. We also demonstrated that in H295R cells TGF-3 inhibited both basal and forskolin-stimulated accumulation of CYP17 mRNA. Determination of promoter ac­tivity, directing luciferase reporter gene expression in H295R cells transfected with deletion fragments of bovine CYP17 promoter, indicated that the -483 to -433 bp fragment of the promoter was necessary for the inhibitory action of TGF-3 on CYP17 expression. It is concluded that in bovine and human adrenocortical cells, androgens inhibit basal CYP17 expression probably at the transcriptional level and independently of the effect of TGF-3.
4

Bronchial hyper-responsiveness, subepithelial fibrosis, and transforming growth factor-beta1 expression in patients with long-standing and recently diagnosed asthma

86%
Tomkowicz A., Kraus-Filarska M., Bar J., Rabczynski J., Jelen M., Piesiak P., Fal A., Panaszek B.
Archivum Immunologiae et Therapiae Experimentalis
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2008
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tom 56
|
nr 6
401-408
5

Epithelial–mesenchymal transition in chronic rhinosinusitis: differences revealed between epithelial cells from nasal polyps and inferior turbinates

86%
Konnecke M., Burmeister M., Pries R., Boscke R., Bruchhage K.-L., Ungefroren H., Klimek L., Wollenberg B.
Archivum Immunologiae et Therapiae Experimentalis
|
2017
|
tom 65
|
nr 2
6

The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes

86%
Sanz-Ramos P., Dotor J., Izal-Azcarate I.
Cellular and Molecular Biology Letters
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2014
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tom 19
|
nr 4
We aim to demonstrate the role of Alk receptors in the response of hydrogel expansion. Chondrocytes from rat knees were cultured onto plastic and hydrogel surfaces. Alk-1 and Alk-5 were overexpressed or silenced and the effects on cells during expansion were tested and confirmed using peptide inhibitors for TGFβ. Overexpression of Alk-5 and silencing of Alk-1 led to a loss of the chondrocyte phenotype, proving that they are key regulators of chondrocyte mechanosensing. An analysis of the gene expression profile during the expansion of these modified cartilage cells in plastic showed a better maintenance of the chondrocyte phenotype, at least during the first passages. These passages were also assayed in a mouse model of intramuscular chondrogenesis. Our findings indicate that these two receptors are important mediators in the response of chondrocytes to changes in the mechanical environment, making them suitable targets for modulating chondrogenesis. Inhibition of TGFβ could also be effective in improving chondrocyte activity in aged or expanded cells that overexpress Alk-1.
7

Transforming growth factor-beta activation in cell-free extracellular matrix preparations. Commentary

86%
Couchman J. R.
Folia Histochemica et Cytobiologica
|
2019
|
tom 57
|
nr 4
8

Expanding diversity and common goal of regulatory T and B cells. I: origin, phenotype, mechanisms

86%
Bocian K., Kiernozek E., Domagala-Kulawik J., Korczak-Kowalska G., Stelmaszczyk-Emmel A., Drela N.
Archivum Immunologiae et Therapiae Experimentalis
|
2017
|
tom 65
|
nr 6
9

Bifunctional T cell clones challenge the traditional compartmentalization concept of the immune system

86%
Naor D.
Archivum Immunologiae et Therapiae Experimentalis
|
1992
|
tom 40
|
nr 1
10

The Smad pathway in TGF-beta signalling

86%
Piestrzeniewicz D., Brys M., Krajewska W. M.
Cellular and Molecular Biology Letters
|
2000
|
tom 05
|
nr 3
The recent identification of the Smad proteins has allowed the delineation of a mechanism by which TGF-β and related growth and differentiation factors convey their signals from transmembrane receptors into nucleus. Following receptor-induced activation heteromeric Smad complexes translocate into the nucleus where they act as transcription factors. Smad proteins modulate target genes through interaction with DNA and with other nuclear factors. Disruption of signalling cascade by Smad gene aberrations may cause loss of cellular responsiveness to TGF-β and thus contribute to development of cancer.
11

Effect of infliximab on the levels of TNF-alpha and TGF-beta in the whole blood cultures of irradiated patients

72%
Staroslawska E., Czarnocki K. J., Koziol-Montewka M., Donica H., Magrys A.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 3
291-297
12
Content available remote

The role of peroxisome-proliferator-activating receptor gamma agonists: rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in chronic experimental cyclosporine A-induced nephrotoxicity

72%
Korolczuk A., Maciejewski M., Smolen A., Dudka J., Czechowska G., Widelska I.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 6
13

Combined perioperative plasma endoglin and VEGF-A assessment in colorectal cancer patients

72%
Mysliwiec P., Pawlak K., Kuklinski A., Kedra B.
Folia Histochemica et Cytobiologica
|
2008
|
tom 46
|
nr 4
487-492
14

TGFbeta (transforming growth factor beta) superfamily members and their receptors in the fetal porcine ovaries: effect of prenatal flutamide treatment

72%
Knapczyk-Stwora K., Grzesiak M., Duda M., Koziorowski M., Galas J., Slomczynska M.
Folia Histochemica et Cytobiologica
|
2014
|
tom 52
|
nr 4
15
Content available remote

Sulodexide modulates the dialysate effect on the peritoneal mesothelium

72%
Misian M., Baum E., Breborowicz A.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 6
16
Content available remote

Atorvastatin-induced endothelial nitric oxide synthase (eNOS) expression in endothelial cells is mediated by endoglin

72%
Zemankova L., Varejckova M., Dolezelova E., Fikrova P., Jezkova K., Rathouska J., Cerveny L., Botella L. M., Bernabeu C., Nemeckova I., Nachtigal P.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 3
17

The effect of femoral nerve block on fracture healing via expressions of growth factors and beta-catenin

72%
Uslu S., Irban A. G., Gereli A., Aydinlar E. I., Elpen P., Ince U.
Folia Histochemica et Cytobiologica
|
2016
|
tom 54
|
nr 3
18

Low frequency of regulatory T cells in the peripheral blood of children with type 1 diabetes diagnosed under the age of five

72%
Szypowska A., Stelmaszczyk-Emmel A., Demkow U., Luczynski W.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
|
tom 60
|
nr 4
19

Role of TGF-beta in self-peptide regulation of autoimmunity

72%
Singh B., Krawetz M. D., De Lima R. M., Mukherjee R., Chaturvedi P., Lee-Chan E., Leiter E. H., Summers K. L.
Archivum Immunologiae et Therapiae Experimentalis
|
2018
|
tom 66
|
nr 1
20

The role of periostin in neoplastic processes

72%
Ratajczak-Wielgomas K., Dziegiel P.
Folia Histochemica et Cytobiologica
|
2015
|
tom 53
|
nr 2
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