During the years 1993-2005 232 dogs suspected of autoimmune mediated diseases (18 cases in years 1993-2001; 17 in 2002; 48 in 2003; 90 in 2004 and 59 in 2005) were examined. Detection of anti-erythrocyte antibodies was performed on 213 vein blood samples using Coombs test. Antinuclear antibodies (ANA) were estimated in 124 and circulating immune complexes (CIC) in 96 serum samples. In 13 cases immunohistochemical examination of skin or inner organ sections was done. The described methods were utilized in the diagnosis and treatment monitoring of immune mediated hemolytic anemia (IMHA) and systemic lupus erythematosus (SLE) cases. The frequency of positive results was estimated in clinically defined cases. Over 71% SLE or SLE-suspected patients presented positive ANA results, and all of them had elevated concentrations of CIC. In cases of IMHA/suspected IMHA, about 78% showed positive Coombs test while IgG class titers mostly exceeded 1:640.
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