Wyniki wyszukiwania

1

The influence of arginine vasopressin (AVP) on phagocytosis in the unicellular Tetrahymena

100%

Jahn I., Csaba G.

Acta Protozoologica

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1987

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tom 26

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nr 1

2

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Oral selenium supplementation and its effect on triiodothyronine and thyroxine concentrations in sheep

86%

Bik D., Kondracki M., Niemczuk K.

Bulletin of the Veterinary Institute in Puławy

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1998

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tom 42

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nr 2

Experiments were performed on 12 sheep divided into 2 groups and fed a standard diet. The trial group received the same nutritive fodder supplemented with 0.3 ppm of sodium selenite (Na₂SeO3). The concentrations of selenium, triiodothyronine and thyroxine in serum were determined every 4 weeks during 20 weeks, respectively. Oral supplements of sodium selenite increased the serum concentration of selenium in sheep from 0.34 ± 0.19 to 4.25 ± 0.69 μmol/l. Contrary to those in the control group, serum Se content ranged from 0.34 ± 0.08 to 0.36 ± 0.10 μmol/I. Alterations in the metabolism of thyroid hormones showed that supplements of selenium produced an insignificant decrease of thyroxine with a slight increase in triiodothyronine concentration.

3

Activity of aminoacyl-tRNA synthetases in some tissues of thyroxinized rabbits

86%

Pasternak K., Szymonik-Lesiuk S., Brzuszkiewicz-Zarnowska H., Borkowski T.

Applied Biology Communications. Lublin Scientific Center

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1994

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tom 04

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nr 3-4

4

Structural basis of negative cooperativity in transthyretin

86%

Neumann P., Cody V., Wojtczak A.

Acta Biochimica Polonica

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2001

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tom 48

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nr 4

A comparison of the AC and BD binding sites of transthyretin (TTR) was made in terms of the interatomic distances between the Ca atoms of equivalent amino acids, measured across the tetramer channel in each binding site. The comparison of the channel diameter for apo TTR from different sources revealed that in the unliganded transthyretin tetramers the distances between the A, D and H β-strands are consistently larger, while the distances between the G β-strands are smaller in one site than in the other. These differences might be described to have a 'wave' character. An analogous analysis performed for transthyretin complexes reveals that the shape of the plot is similar, although the amplitudes of the changes are smaller. The analysis leads us to a model of the changes in the binding sites caused by ligand binding. The sequence of events includes ligand binding in the first site, followed by a slight collapse of this site and concomitant opening of the second site, binding of the second molecule and collapse of the second site. The following opening of the first, already occupied site upon ligand binding in the second site is smaller because of the bridging interactions already formed by the first ligand. This explains the negative cooperativity (NC) effect observed for many ligands in transthyretin.

5

Effects of thyroxine treatment during lactation on the testicular function of rats across different ages

72%

Dahmani-Said S., Hamouli-Said Z., Kamel A., Hadj-Bekkouche F.

Folia Histochemica et Cytobiologica

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2013

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tom 51

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nr 2

6

Thyroid hormone at supra-physiological dose optimizes cardiac geometry and improves cardiac function in rats with old myocardial infarction

72%

Pantos C., Mourouzis I., Tsagoulis N., Markakis K., Galanopoulos G., Roukounakis N., Perimenis P., Liappas A., Cokkinos D. V.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 3

49-56

Thyroid hormone (TH) is critical in cardiac cell differentiation (regulating contractile proteins and cell geometry) and this effect could be potentially exploited therapeutically in reversing the process of de-differentiation which underlies postischemic cardiac remodeling. Acute myocardial infarction was induced in male Wistar rats by ligating left coronary artery (AMI, n=8), while sham operated animals served as control (SHAM, n=8). 13 weeks after AMI, TH was administered in a group of animals for 4 weeks (AMI-THYR, n=9). TH significantly increased ß-MHC and decreased -MHC expression in the myocardium. This response was accompanied by changes in cardiac geometry: sphericity index, (SI, long to short axis ratio) was found to be 1.95 (SEM, 0.02) in SHAM, 1.51(0.03) in AMI and 1.64(0.03) in AMI-THYR, p<0.05. As a consequence, cardiac function was significantly improved: left ventricular ejection fraction (EF%) was 74.5% (SEM, 2.8) in SHAM vs 29.5% (2.1) in AMI, and 40.0% in AMI-THYR, p<0.05. Furthermore, +dp/dt and -dp/dt were 4250 (127) and 2278 (55) in SHAM vs 2737(233) and 1508 (95) in AMI vs 3866 (310) and 2137(111) in AMI -THYR, respectively, p<0.05. TH treatment partially reverses cardiac dysfunction in rats with old myocardial infarction by favorably changing cardiac chamber geometry and expression of myosin isoforms. Thyroid hormone, unlike current treatments, appears to be a paradigm of therapeutic intervention which aims at restoring cardiac geometry and may prove new effective treatment for heart failure.

7

Proliferative activity of thyroid follicular cells in non-neoplastic goitre and the level of selected thyroid hormones in blood serum

72%

Dzieciol J., Maldyk J., Lebkowska U., Sawicki B., Augustynowicz A., Gorska M.

Folia Histochemica et Cytobiologica

|

1999

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tom 37

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nr 2

8

Roles of thyroid, adrenal and pancreatic hormones on thyroid activity of the soft-shelled turtles Lissemys punctata punctata Bonnoterre

72%

Ray P. P., Sarkar S., Sengupta A., Chaudhuri-Sengupta S., Maiti B. R.

Folia Biologica

|

2006

|

tom 54

|

nr 3-4

9

Circadian variations of thyrotropin [TSH], triiodothyronine [T3] and thyroxine [T4] in surgical and functional pinealectomy in rats

72%

Ostrowska Z., Zwirska-Korczala K., Buntner B., Jarzab B., Kucharzewski M.

Bulletin of the Polish Academy of Sciences. Biological Sciences

|

1994

|

tom 42

|

nr 1

10

The variability of thyroid hormones level and plasma protein fractions in Polar foxes blood at different times after feeding

72%

Rajs R., Glowinska B., Szymeczko R., Boguslawska M., Burlikowska K.

Zeszyty Naukowe. Przegląd Hodowlany

|

1996

|

tom 28

11

Effects of chromium picolinate, L-carnitine and thyroxine on the performance, nutrient digestibility and nitrogen balance in pigs weaned at 21 days of age

72%

Cho W.T.Han I.K., Chae B. J., Han Y. K., Ha J. K., Odle J.

Journal of Animal and Feed Sciences

|

2000

|

tom 09

|

nr 4

12

Experimental hypothyroidism increases content of collagen and glycosaminoglycans in the heart

58%

Drobnik J., Ciosek J., Slotwinska D., Stempniak B., Zukowska D., Marczynski A., Tosik D., Bartel H., Dabrowski R., Szczepanowska A.

Journal of Physiology and Pharmacology

|

2009

|

tom 60

|

nr 3

57-62

The connective tissue matrix of the heart remains under regulatory influence of the thyroid hormones. Some conflicting data describe the connective tissue changes in subjects with thyroid gland disorders. The aim of the study was to assess the changes of the connective tissue accumulation in the heart of rats in the state of hypothyroidism and to answer the question whether TSH is involved in mechanism of the observed phenomena. Hypothyroidism in rats was induced by methylotiouracil treatment or by thyreoidectomy. The thyroid hormones [freeT3 (fT3), freeT4 (fT4)] and pituitary TSH were measured in plasma with radioimmunological method. The glycosaminoglycans (GAG) and total collagen were measured in heart muscle of both left and right ventricles. Cells from the rat’s heart were isolated and cultured. The cells were identified as myofibroblasts by electron microscopy method. The effects of TSH in concentrations ranging from 0.002 to 20 mIU/ml, on connective tissue accumulation in heart myofibroblasts cultures were tested. The primary hypothyroidism was developed both in groups with thyroidectomy and with methylthiouracil. The levels of fT3 and fT4 both in rats with thyreoidectomy and animals treated with methylthiouracil were decreased and TSH level in these two experimental groups was elevated. In the heart of the rats with experimental hypothyroidism increased content of both GAG and collagen was found. Myofibroblast number in culture was increased by TSH. Regardless of the method of its induction, hypothyroidism increased collagen and GAG contents in the heart. TSH is not involved in regulation of collagen and glycosaminoglycans accumulation in the heart of rats affected with primary hypothyroidism.

13

The cyclic nucleotide-IGF-I systems as possible mediator of effect of nutrition on ovarian activity in domestic nutria (Myocastor coypus)

58%

Sirotkin A., Mertin D., Suvegova K., Makarevich A., Genieser H.-G., Osadchuk L.

Zeszyty Naukowe. Przegląd Hodowlany

|

1999

|

tom 42

14

Thyroid hormones in the cerebrospinal fluid of the third ventricle of adult female sheep during different periods of reproductive activity

58%

Skipor J., Misztal T., Szczepkowska A.

Polish Journal of Veterinary Sciences

|

2010

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tom 13

|

nr 4

Thyroid hormones (THs) are obligatory for transition from breeding season to anestrus in sheep. In this process, THs act during a very limited time of the year and primarily within the brain. In ewes chronically equipped for sampling cerebrospinal fluid (CSF) from the third ventricle, we have characterized the concentrations of total and free thyroxine (T4), triiodothyronine (T3), and total reverse T3 (rT3) in the CSF during breeding season, anestrus and during a critical period required for transition to anestrus (December-March). The total T4, T3, rT3 and free T3 average concentrations (± SEM) in CSF were 1.5 ± 0.07 ng/ml, 14.5 ± 1.2 pg/ml, 43 ± 7.4 pg/ml, and 0.6 ± 0.05 pg/ml, respectively, and all were significantly lower (p < 0.001) than in blood plasma except free T4 (12.6 ± 1.1 pg/ml), which was similar to that in plasma. There was a seasonal trend (p < 0.05) in the concentration of total T3 (highest in December) and free T4 (highest in November) in the CSF that does not follow that in blood plasma. During the period of transition to anestrus the CSF total T3/TT4 molar ratio and free T3/ T4 ratio were significantly lower (p < 0.05 and p < 0.01, respectively) than in blood plasma, while the total rT3/T4 ratio was significantly higher (p < 0.01) at the end of this period (March). Additionally, the CSF total rT3 concentrations were also significantly correlated with the CSF total T4 levels (r = 0.57; p < 0.05). In conclusion, the CSF in sheep may serve as a considerable source of thyroid hormones for neuroendocrine events. The lack of significant changes in THs concentrations in the CSF during the period of transition to anestrus indicate that neither seasonal changes of THs circulating in the blood plasma nor THs circulating in the CSF actively drive the transition to anestrus.

15

Effect of thyroxin induction on enzymatic and biochemical levels in albino rats

58%

Hanchinalmath J. V., Shivasharanappa K., Roopa T. S., Saisundeep Y.

International Letters of Natural Sciences

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2014

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tom 08

|

nr 2

The albino Wistar rats were used to investigate the effect of thyroxine administration on the activity of citric acid, α-Amylase, creatine phosphokinase (CPK), creatinine, cholesterol and triglycerides level in blood serum and citric acid in liver and kidney. Two groups of rats were taken for the experiment. One group was injected subcutaneously with 200 μl of thyroxine/50 g of body weight, the other group served as control. The animals were vivisected with anesthesia after intervals of 24, 48, 72 and 96 hours α-Amylase and CPK levels in blood; citric acid level in liver and kidney of control and thyroxine treated rats. The results showed that the α-Amylase activity remained unaltered (100 g/h/l) throughout the experiment. However, citric acid level found to be 460 mg in the liver and 415 mg in kidney of control rats. The values slightly increased to 480 and 680 mg in respective tissues of thyroxine treated animals for 24 hr. The values decreased in 48 and 72 hours of treatment. Further the values found to be increased after 96 hours of treatment. Although the thyroxine treatment altered citric acid, Creatinine, Cholesterol, Triglycerides and CPK levels in the tissues, the serum α-Amylase was not influenced by the thyroxine. The study suggests that the thyroxine acts as a regulator all the above parameters in the cellular level.

16

Biochemical and hormonal characteristics of peripheral blood in bulls in relation to genotype

58%

Glowinska B., Oler A.

Folia Biologica

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2013

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tom 61

|

nr 1-2

17

Effects of the season on physiological and endocrine traits and on HSP70 in Saanen goats under Mediterranean climate conditions

58%

Yilmaz M., Altin T., Kiral F., Taskin T., Ekren Asici G. S., Kizilkaya K.

Medycyna Weterynaryjna

|

2018

|

tom 74

|

nr 01

This study was conducted to determine the impact of heat stress on some physiological and endocrine traits in Saanen goats raised under Mediterranean climate conditions. The effects of thermal stress on heart rate (HR), respiration rate (RR) and rectal temperature (RT) on plasma total trii-odothyronine (T3), thyroxine (T4), Cortisol (C), and HSP70 concentrations were evaluated on twenty two Saanen goats of different ages in the second week of April 2013, July 2013, October 2013 and January 2014. Climatic data such as temperature (°C) and relative humidity (%) were recorded from Spring 2013 to Winter 2014. Live body and BCS values were also recorded during this period. The physiological parameters above were measured twice on each experiment day (morning and afternoon) in all seasons. Blood samples were collected in each afternoon of the experiment day to analyze T3, T4 C, and HSP70. All data were analyzed. According to the values of rectal temperature (RT), it was estimated that the goats were under extreme heat stress only in the summer season. The heart rate (HR) values in the winter season for morning and noon periods were found statistically significant (p < 0.05). The average respiratory rate (RR) in the spring season was found significantly lower. On the other hand, the RR for the noon period in the summer was higher than in the fall and winter seasons (p < 0.05). There was a significant difference (p < 0.05) between summer and fall seasons for C values. The highest value (96.62 ng/ml) was obtained in spring, whereas the lowest (60.58 ng/ml) in the fall. T3 levels in the fall and winter were found to be statistically significant (p < 0.05). They were the highest in the winter and spring, and the lowest in fall. T4 and T4/T3 levels in the winter were found to be statistically higher than in other seasons (p < 0.05). The lowest value for T4 was found in the fall and for T4/T3 in summer. Mean HSP70 value in spring was found to be statistically low (p < 0.05). The changes in THI values in different seasons, particularly between mornings and afternoons, indicated that thermal stress was evident, and that the animals became resistant to it eventually. The fluctuations of the C, T3, T4 and HSP70 values were indicators of the animals’ reaction to thermal stress. The THI values in spring, which were between 16 and 18 THI, may be considered within the ideal comfort zone for goats. It was observed that Saanen goats were able to adapt to seasonal weather changes in the environmental conditions of the region.

18

The level of selected hormones in peripheral blood in female polar foxes [Alopex lagopus L.] in relation to age

58%

Szymeczko R., Mackowiak P., Piotrowska A., Boguslawska-Tryk M., Burlikowska K., Pruszynska-Oszmalek E., Sassek M., Szczepankiewicz D.

Folia Biologica

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2009

|

tom 57

|

nr 3-4

213-218

19

Obwodowy metabolizm tyroksyny [T4] i trojjodotyroniny [T3] u owiec pozbawinych paszy

58%

Wronska-Fortuna D., Niezgoda J., Sechman A., Bobek S., Kugiel M.

Acta Agraria et Silvestria. Series Zootechnica

|

1992

|

tom 30

117-122

20

The immunohistochemical demonstration of parafollicular cells and evaluation of calcium-phosphate balance in patients with thyroid hemiagenesis

58%

Ruchala M., Szczepanek E., Sujka-Kordowska P., Zabel M., Biczysko M., Sowinski J.

Folia Histochemica et Cytobiologica

|

2011

|

tom 49

|

nr 2

Ograniczanie wyników

The influence of arginine vasopressin (AVP) on phagocytosis in the unicellular Tetrahymena

Oral selenium supplementation and its effect on triiodothyronine and thyroxine concentrations in sheep

Activity of aminoacyl-tRNA synthetases in some tissues of thyroxinized rabbits

Structural basis of negative cooperativity in transthyretin

Effects of thyroxine treatment during lactation on the testicular function of rats across different ages

Thyroid hormone at supra-physiological dose optimizes cardiac geometry and improves cardiac function in rats with old myocardial infarction

Proliferative activity of thyroid follicular cells in non-neoplastic goitre and the level of selected thyroid hormones in blood serum

Roles of thyroid, adrenal and pancreatic hormones on thyroid activity of the soft-shelled turtles Lissemys punctata punctata Bonnoterre

Circadian variations of thyrotropin [TSH], triiodothyronine [T3] and thyroxine [T4] in surgical and functional pinealectomy in rats

The variability of thyroid hormones level and plasma protein fractions in Polar foxes blood at different times after feeding

Effects of chromium picolinate, L-carnitine and thyroxine on the performance, nutrient digestibility and nitrogen balance in pigs weaned at 21 days of age

Experimental hypothyroidism increases content of collagen and glycosaminoglycans in the heart

The cyclic nucleotide-IGF-I systems as possible mediator of effect of nutrition on ovarian activity in domestic nutria (Myocastor coypus)