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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Effect of bed rest on the adenine nucleotides concentration in human blood platelets

100%
Buczynski A., Kedziora J., Wachowicz B., Zolynski K.
Journal of Physiology and Pharmacology
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1991
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tom 42
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nr 4
The effect of immobilization in bed on metabolism and function of human blood platelet was studied. Blood platelets taken from patients with bone fractures after long term bed rest (14 days and 28 days) demonstrated significantly reduced concentration of total adenine nucleotides (after 28 days reduction about 30%). This decrease of total platelet adenine nucleotides af er immobilization in bed is probably caused by s imulation of platelet secretory process. Thrombin which released from confrol platele s 58.2%±1.5% of total adenine nucleotides liberated decreased amounfs (only 23.1 %±3.3% of total) of nucleotides from patient platelets isolated after 28 days of immobilization in bed. Loss of nucleotides from platelets was accompanied by sligh ly increased extent of platelet aggregation. It is concluded that during bed rest the reactivity of blood platelets (aggregation and release reaction) is stimulated.
2
Content available remote

Cleavage of prothrombin bound in immune complexes results in high thrombin enzymatic activity

100%
Pajdak W., Radwan J., Guzik T. J.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 2
Thrombin plays a pivotal role in blood clotting as well as in the regulation of vascular remodeling and oxidative stress. Recent evidence suggests that auto-antibodies directed against prothrombin, may play an important role in the pathogenesis of atherosclerosis. It is however not clear, if prothrombin bound in an immune complex retains its clotting and regulatory properties or acts solely by increasing vascular inflammation. In order to answer this question, we used a newly developed stain for the detection of thrombin activity of such complexes. Plasma and serum samples were subjected to rocket immunoelectrophoresis in an anti-prothrombin antiserum containing agarose gel. Gel plates, covered with a nitrocellulose membrane were soaked with chromogenic thrombin substrate. The product of thrombin activity was diazotized to red azo dye bound to nitrocellulose. Activity stain revealed barely discernible rockets in plasma, but heavily stained ones in serum. Pre-incubation with trypsin enhanced activity of immunoprecipitates deriving from plasma, but not from serum. Densitometric analysis showed, that the trypsin-enhanced activity in plasma derived immune complexes was twice as high as in serum derived immunoprecipitates. Thrombin active centre is not blocked by anti-prothrombin antiserum allowing to retain thrombin activity. Moreover, prothrombin in immunoprecipitate is readily cleaved by proteolytic enzymes. This cleavage could potentially be enhanced by antibody binding, although these results need to be confirmed using different antibodies.
3

Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-alpha in human dermal microvascular endothelial cells

84%
Del Socorro Pina-Canseco M., Paez-Arenas A., Masso F., Perez-Campos E., Martinez-Cruz R., Hernandez-Cruz P., Majluf-Cruz A., Martinez-Cruz M., Perez-Campos Mayoral L., Perez-Santiago A. D., Zenteno E.
Folia Histochemica et Cytobiologica
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2012
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tom 50
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nr 3
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Effects of submaximal physical exercise and immobilization in bed on the adenine nucleotides concentration in human blood platelets

84%
Buczynski A., Kedziora-Kornatowska K., Kedziora J., Wachowicz B.
Journal of Physiology and Pharmacology
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1995
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tom 46
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nr 2
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