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1

Feasibility of in vivo magnetoliposome targeting

100%
Babincova M., Altanerova V., Lampert M., Altaner C., Machova E., Sramka M., Babinec P.
Cellular and Molecular Biology Letters
|
1999
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tom 04
|
nr 2
2

P38 MAP kinase inhibitors - mechanisms and therapeutic potentials

100%
Lee J. C.
Cellular and Molecular Biology Letters
|
1998
|
tom 03
|
nr 3
3

Impact of roscovitine, a selective CDK inhibitor, on cancer cells: bi-functionality increases its therapeutic potential

86%
Wesierska-Gadek J., Brzoza A., Komina O., Maurer M.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 3
495-501
 Increased expression and activity of proteins driving cell cycle progression as well as inactivation of endogenous inhibitors of cyclin-dependent kinases (CDKs) enhance the proliferative potential of cells. Escape of cells during malignant transformation from the proper cell cycle control rendering them independent from growth factors provides rationale for therapeutic targeting of CDKs. Exposure of rapidly growing human MCF-7 breast cancer and HeLa cervix cancer cells to roscovitine (ROSC), a selective inhibitor of CDKs, inhibits their proliferation by induction of cell cycle arrest and/or apoptosis. The outcome strongly depends on the intrinsic traits of the tumor cells, on their cell cycle status prior to the onset of treatment and also on ROSC concentration. At lower dose ROSC primarily inhibits the cell cycle-related CDKs resulting in a strong cell cycle arrest. Interestingly, ROSC arrests asynchronously growing cells at the G2/M transition irrespective of the status of their restriction checkpoint. However, the exposure of cancer cells synchronized after serum starvation in the late G1 phase results in a transient G1 arrest only in cells displaying the intact G1/S checkpoint. At higher dosage ROSC triggers apoptosis. In HeLa cells inhibition of the activity of CDK7 and, in consequence, that of RNA polymerase II is a major event that facilitates the initiation of caspase-dependent apoptosis. In contrast, in the caspase-3-deficient MCF-7 breast cancer cells ROSC induces apoptosis by a p53-dependent pathway. HIPK2-mediated activation of the p53 transcription factor by phosphorylation at Ser46 results in upregulation of p53AIP1 protein. This protein after de novo synthesis and translocation into the mitochondria promotes depolarization of the mitochondrial membrane.
4
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In vitro production of huperzine A and other Lycopodium alkaloids in Huperzia selago through a prothallus culture under the influence of different additives

86%
Szypula W. J., Pietrosiuk A.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2015
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tom 96
|
nr 1
5

Purinergic signaling in the pancreas and the therapeutic potential of ecto-nucleotidases in diabetes

86%
Cieslak M., Roszek K.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 4
6

The therapeutic potential of interleukin 10 in infection and inflammation

72%
Kumar A., Creery W. D.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
tom 48
|
nr 6 Spec.Iss.
529-538
7
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Content available

A systematic review of the characteristics, phytonutritive, and therapeutic potential of the date palm fruit (Phoenix dactylifera)

72%
Sharma G., Sharma V., Mishra T.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2019
|
tom 100
|
nr 2
8
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Content available

Yeast extract-mediated elicitation of anti-cancerous compounds licoisoflavone B, licochalcone A, and liquirtigenin in callus cultures of Glycyrrhiza glabra

72%
Vijayalakshmi U., Shourie A.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2019
|
tom 100
|
nr 4
9

Clinical use and therapeutic potential of IVIG/SCIG, plasma-derived IgA or IgM, and other alternative immunoglobulin preparations

72%
Spath P. J., Schneider C., von Gunten S.
Archivum Immunologiae et Therapiae Experimentalis
|
2017
|
tom 65
|
nr 3
10
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Nigerian polyherbal-based hydrotherapy: a panacea to infectious diseases

72%
Lawal I. O., Omogbene T. O.
Herba Polonica
|
2021
|
tom 67
|
nr 2
11
Content available remote

Essentiality and toxicity of vanadium supplements in health and pathology

72%
Gruzewska K., Michno A., Pawelczyk T., Bielarczyk H.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 5
12

Therapeutic potential of induced and natural FoxP3plus regulatory T cells for the treatment of graft-versus-host disease

72%
Prinz I., Koenecke C.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
|
tom 60
|
nr 3
13

Studies on the inhibitory properties of leaf ethanolic extracts obtained from Ficus (Moraceae) species against Aeromonas spp. strains

72%
Pekala-Safinska A., Tkachenko H., Kurhaluk N., Buyun L., Osadowski Z., Honcharenko V., Prokopiv A.
Journal of Veterinary Research
|
2021
|
tom 65
|
nr 1
14

Therapeutic potential of biological response modifiers against transplantable mouse tumors of spontaneous origin. II. Local interleukin 2 treatment of tumors of different immunogenic strength

72%
Fiszer-Maliszewska L., Den Otter W., Madej J. A., Mordarski M.
Archivum Immunologiae et Therapiae Experimentalis
|
1998
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tom 46
|
nr 5
15

SCID mice model in vivo evaluation of autologous and allogeneic dendritic cells activity on B-cell chronic lymphocytic leukemia

58%
Hus I., Kawiak J., Hoser G., Tabarkiewicz J., Radej S., Dmoszynska A., Rolinski J.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 4
16

Therapeutic potential of biological response modifiers against transplantable mouse tumors of spontaneous origin. I. Characterization of biological properties of tumor lines and preliminary data on response to cytostatic drugs and biomodulators

58%
Fiszer-Maliszewska L., Mordarski M., Madej J. A.
Archivum Immunologiae et Therapiae Experimentalis
|
1993
|
tom 41
|
nr 1
17
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Therapeutic potential of heme oxygenase-1 in cardiovascular disease

51%
Jazwa A., Florczyk U., Stepniewski J., Jozkowicz A., Dulak J.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2011
|
tom 92
|
nr 2
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