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Toxic effect of single walled carbon nanotubes combined with cadmium to the crustacean Daphnia magna

100%

Revel M., Fournier M., Robidoux P. Y.

International Letters of Natural Sciences

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2015

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tom 42

The aim of this study was to assess the impact of single-walled carbon nanotubes (SWCNT) on the toxicity of cadmium (Cd) using the crustacean Daphnia magna. LC50 of Cd and SWCNT alone and combined were calculated and compared. Sorption of Cd on SWCNT was also quantified in separate batch experiments. Results showed that the maximum adsorption of Cd onto SWCNT calculated by the Langmuir equation was 24.4 mg kg-1. LC50s for Cd and SWCNT alone were 252.3 μg L-1 and 1400 μg L-1, respectively. In the presence of 500 and 1000 μg L-1 of SWCNT, Cd LC50s were 127.2 and 120.1 μg L-1 respectively. Therefore, Cd toxicity increased when organisms were exposed to both contaminants which indicated that SWCNT induces a synergistic toxic effect on the survival of D. magna. It appears that even if SWCNT had a low adsorption capacity for Cd, toxicity of the metal can be increased. Our study shows the complexity of SWCNT toxicity and how the understanding of their interactions with other contaminants is crucial to determine the consequences of their release into the environment.

2

Comparison of antioxidative and synergistic effects of skullcap (Scutellaria baicalensis Georgi) in sunflower oil-in-water emulsion during storage

84%

Wojdylo A., Oszmianski J., Sokol-Letowska A.

Electronic Journal of Polish Agricultural Universities. Series Food Science and Technology

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2007

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tom 10

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nr 2

3

The synergistic effect of boric acid and ammonium polyphosphate on the thermal degradation and flammability of pine-needles

84%

Li L., Hu H., Guo C., Hu H.

Drewno. Prace Naukowe. Doniesienia. Komunikaty

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2014

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tom 57

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nr 193

The synergistic effect of ammonium polyphosphate (APP) and boric acid (BA) on the flame retardancy and thermal degradation of pine needles was investigated. Thermogravimetric analysis (TGA) showed that the presence of an ammoniumpolyphosphate and boric acid system increased the char residue and decreased the pyrolysis temperature of the pine needles. The derivative thermogravimetric analysis (DTG) showed that the ammonium polyphosphate and boric acid had shifted the degradation peaks of the pine needles to lower temperatures. The cone calorimetry test results showed that the values of HRR, THR, SPR, TSP and the mass loss (%) of the pine needles treated with ammonium polyphosphate and boric acid (APP/BA = 3/2)were significantly lower than the other samples. Therefore, the APP and BA system had a better effect on the pine needles overall than the APP alone.

4

Synergistic effects against post-ischemic cardiac dysfunction by sub-chronic nandrolone pretreatment and postconditioning: role of beta2-adrenoreceptors

84%

Penna C., Abbadessa G., Mancardi D., Tullio F., Piccione F., Spaccamiglio A., Racca S., Pagliaro P.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 4

645-659

ß2-adrenoreceptor overexpression is beneficial against ischemia/reperfusion (I/R) injury. Whether ß-adrenoreceptors are involved in postconditioning (PostC) is unknown. We investigated whether nandrolone-decanoate (ND)-pretreatment can modulate (1) ß-adrenoreceptor expression and (2) post-ischemic cardiac function in response to I/R and PostC. Finally, we tested whether cardioprotection can be prevented by the inhibition of ß2-adrenoreceptors. Isolated rat hearts from ND-pretreated (15 mg/kg/day i.m., for 14 days) and untreated-animals underwent 30-min ischemia and 120-min reperfusion. In subgroups, at the end of ischemia a PostC protocol (five cycles of 10-s reperfusion and 10-s ischemia) was applied and/or a ß2-adrenoreceptor blocker, ICI-118.551 (10 µM), was infused. Left ventricular pressure (LVP) was measured with an electromanometer, and infarct-size was evaluated using nitro-blue-tetrazolium staining. ND-pretreatment increased ß2-adrenoreceptor expression, but did not alter cardiac-weight, LVP and maximum rate of increase of LVP (dP/dtmax). After I/R, infarct-size was smaller in ND-pretreatment than in untreated-animals. Infarct-size was also reduced by PostC, both in untreated and ND-pretreated animals. Contracture was less marked in ND-pretreated animals. PostC reduced contracture in both ND-pretreated and untreated hearts. Moreover, PostC improved post-ischemic recovery of developed LVP and dP/dtmax much more in hearts of ND-pretreated than untreated-animals. ICI-118.551 abolished ND-protection and PostC-protection both in ND-pretreated and untreated hearts. Data show that two-weeks ND-pretreatment induces 1) an overexpression of ß2-ARs without cardiac hypertrophy and 2) improves the post-ischemic diastolic and systolic cardiac function. Intriguingly, ND-pretreatment potentiates the improvement of systolic function induced by postconditioning via ß2-adrenoreceptor activation.

5

The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats

84%

Skuza G., Rogoz Z.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 2

Data acquired to date show that some sigma receptor ligands reveal "antidepressant-like" activity in the forced swim test in mice and rats. Moreover, our preliminary results suggested that joint administration of sigma receptor ligands and amantadine (AMA, a glutamatergic/NMDA receptor antagonist) caused a positive interaction in the Porsolt test in rats, as had already been observed in the case of co-treatment with clinically active antidepressants and AMA. The aim of the present study was to examine the effect of combined administration of sigma1 or sigma2 receptor agonists, SA4503 or siramesine, respectively, and AMA or memantine (MEM) (uncompetitive NMDA receptor antagonist). SA4503 or siramesine given jointly with MEM (as well as with AMA) decreased the immobility time in rats. The effect of SA4503 and AMA co-administration was antagonized by progesterone, a sigma1 receptor antagonistic neurosteroid. Combined treatment with siramesine and AMA was modified by neither progesterone nor BD1047 (a novel sigma antagonist with preferential affinity for sigma1 sites); but it was counteracted by sulpiride and prazosin (a dopamine D2- and an alpha1-adrenergic receptor antagonist, respectively). The "antidepressant-like" effect induced by siramesine and MEM was not antagonized by progesterone, but was attenuated by BD1047, sulpiride and prazosin. The obtained results give support to the hypothesis that sigma (particularly sigma1) receptors may be one of the possible mechanisms by which drugs induce antidepressant-like activity in the forced swim test, and that this effect may be enhanced by NMDA receptor antagonists. Combined treatment with sigma ligands and AMA or MEM (applied in the clinic) may be an alternative to the treatment of antidepressant-resistant depressive patients in the future.

6

Synergistic effect of cefotaxime and normal human serum on bactericidal activity against urinary strains of Escherichia coli with capsular antigen K1

84%

Franciszek R., Jankowski S.

Acta Microbiologica Polonica

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1993

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tom 42

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nr 3-4

7

Synergistic effects of amyloid peptides and lead on human neuroblastoma cells

67%

Suresh C., Johnson J., Mohan R., Chetty C. S.

Cellular and Molecular Biology Letters

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2012

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tom 17

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nr 3

Aggregated amyloid peptides (AP), major components of senile plaques, have been considered to play a very important and crucial role in the development and neuro-pathogenesis of Alzheimer’s disease (AD). In the present in vitro, study the synergistic effects of Pb2+, a heavy metal, and AP on the human neuroblastoma SH-SY5Y cells were investigated. The cells treated with Pb2+ (0.01–10 μM) alone exhibited a significant decrease in viability and IC50 was 5 μM. A similar decrease in viability was also observed when the cells were exposed to AP, Aβ1–40 (20–120 μM) and Aβ25-35 (2.5–15 μM) for 48 hrs. The IC50 values were 60 μM and 7.5 μM for Aβ1–40 and Aβ25–35 respectively. To assess the synergistic effects the cells were exposed to IC50 of both AP and Pb2+, which resulted in further reduction of the viability. The study was extended to determine the lactate dehydrogenase (LDH) release to assess the cytotoxic effects, 8-isoprostane for extent of oxidative damage, COX 1 and 2 for inflammation related changes, p53 protein for DNA damage and protein kinases A and C for signal transduction. The data suggest that the toxic effects of AP were most potent in the presence of Pb2+, resulting in an aggravated clinical pathological condition. This could be attributed to the oxidative stress, inflammation neuronal apoptosis and an alteration in the activities of the signaling enzymes.

8

Combination of bacteriocins with various factors as a way of natural food preservation

67%

Jakubczak A., Stachelska M. A., Swislocka R., Kalinowska M., Lewandowski W.

Advances in Agricultural Sciences

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2011

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tom 14

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nr 1-2

9

The synergistic effect of piperonyl butoxide on the molluscicidal potential of monoterpenes and phenylpropenes against Theba pisana

67%

Abdelgaleil S. A. M., Saad M. M. G.

Journal of Plant Protection Research

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2018

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tom 58

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nr 4

The molluscicidal activity of six monoterpenes and two phenylpropenes against Theba pisana adults was evaluated using fumigation and direct contact methods. In the fumigant toxicity assay, (-)-citronellal showed the highest toxicity with LC50 value of 7.79 µl · l−1 air after 24 h of treatment, followed by (-)-terpinen-4-ol (LC50 = 12.06 µl · l−1), (-)-menthone (LC50 = 12.28 µl · l−1 air) and p-cymene (LC50 = 16.07 µl · l−1 air). Eugenol and trans-cinnamaldehyde were the most potent contact toxicants against T. pisana. Their LD50 values were 0.18 and 0.29 mg · snail−1 after 24 h of treatment, respectively. These two compounds were more toxic than a reference molluscicide, methomyl. In contrast, α-terpinene and (-)-citronellal were the least toxic compounds. In another experiment, the synergistic effect of piperonyl butoxide (PBO) on tested monoterpenes and phenylpropenes by topical application was examined. The results showed that the toxicity of the tested compounds was increased when mixed with PBO at a ratio [compound/PBO (1 : 2)] except for α-pinene and (-)-terpinen-4-ol in which the toxicity of binary mixtures was less than for single compounds. The synergistic effect of PBO improved with increased exposure time. The highest synergistic effect was observed with (-)-menthone and α-terpinene with synergistic ratios of 9.25 and 4.37, respectively. Monoterpenes and phenylpropenes and their mixtures with PBO described herein merit further studies as potential T. pisana control agents.

10

Synergistyczne dzialanie wyciagu z tarczycy bajkalskiej i koenzymu Q10

59%

Sawicka E., Dlugosz A., Roszkowska A.

Bromatologia i Chemia Toksykologiczna

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2009

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tom 42

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nr 1

59-64

Ograniczanie wyników

Toxic effect of single walled carbon nanotubes combined with cadmium to the crustacean Daphnia magna

Comparison of antioxidative and synergistic effects of skullcap (Scutellaria baicalensis Georgi) in sunflower oil-in-water emulsion during storage

The synergistic effect of boric acid and ammonium polyphosphate on the thermal degradation and flammability of pine-needles

Synergistic effects against post-ischemic cardiac dysfunction by sub-chronic nandrolone pretreatment and postconditioning: role of beta2-adrenoreceptors

The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats

Synergistic effect of cefotaxime and normal human serum on bactericidal activity against urinary strains of Escherichia coli with capsular antigen K1

Synergistic effects of amyloid peptides and lead on human neuroblastoma cells

Combination of bacteriocins with various factors as a way of natural food preservation

The synergistic effect of piperonyl butoxide on the molluscicidal potential of monoterpenes and phenylpropenes against Theba pisana

Synergistyczne dzialanie wyciagu z tarczycy bajkalskiej i koenzymu Q10