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Cellular components of the bronchoalveolar lavage correlate with lung function impairment and extrapulmonary involvement markers in active sarcoidosis

100%

Chorostowska-Wynimko J., Lesniewska-Radomska D., Krychniak-Soszka A., Remiszewski P., Szopinski J., Wesolowski S., Kus J., Skopinska-Rozewska E.

Journal of Physiology and Pharmacology. Supplement

2004

tom 55

nr 3

41-47

Sarcoidosis is a chronic inflammatory multiorgan disease of unknown origin. Our previous study demonstrated a significant correlation between the relative count of nonCD4+, nonCD8+ lymphocytes in bronchoalveolar lavage of active sarcoidosis patients and proangiogenic activity of BAL homogenates. The aim of the present study was to evaluate in a group of 40 patients with active sarcoidosis the possible relationship between the intensity of alveolitis, particularly the nonCD4+, nonCD8+ lymphocyte subset, and other parameters characterizing the level of pulmonary (lung function tests) and extrapulmonary (spleen longitudinal dimension) disease activity. We found that the relative count of nonCD4+, nonCD8+ lymphocytes in BAL correlated positively with spleen size (r=0.50, P<0.01) and negatively with static compliance (r=0.43, P<0.05). We concluded that the lymphocytes belonging to the nonCD4+nonCD8+ subset participate in the inflammatory process in sarcoidosis. However, more detailed phenotypic and functional characteristics of this cellular population are needed.

Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax – malaria in India and Saudi Arabia

67%

Khan W., Zakai H. A., Asma U.

Acta Parasitologica

2014

tom 59

nr 2

Malaria is one of the most devastating diseases of tropical countries with clinical manifestations such as anaemia, splenomegaly, thrombocytopenia, hepatomegaly and acute renal failures. In this study, cases of thrombocytopenia and haemoglobinemia were more prominent in subjects infected with Plasmodium falciparum (Welch, 1897) than those with Plasmodium vivax (Grassi et Feletti, 1890). However, anaemia, jaundice, convulsions and acute renal failure were significantly high (3–4 times) in subjects infected with P. falciparum than those infected with P. vivax. The incidence of splenomegaly and neurological sequelae were 2 and 6 times higher in P. falciparum infections compared to the infections of P. vivax. Both in P. vivax and P. falciparum malaria, the cases of splenomegaly, jaundice and neurological sequelae were almost double in children (<10 years) compared to older patients. The liver enzymes were generally in normal range in cases of low and mild infections. However, the AST, ALT, ALP activities and serum bilirubin, creatinine, and the urea content were increased in P. falciparum and P. vivax malaria patients having high parasitaemia, confirming liver dysfunction and renal failures in few cases of severe malaria both in India and Saudi Arabia.

Ograniczanie wyników

1 Acta Parasitologica

1 Journal of Physiology and Pharmacology. Supplement

1 Asma U.

1 Chorostowska-Wynimko J.

1 Khan W.

1 Krychniak-Soszka A.

1 Kus J.

1 Lesniewska-Radomska D.

1 Remiszewski P.

1 Skopinska-Rozewska E.

1 Szopinski J.

1 Wesolowski S.

1 Zakai H. A.

1 2014

1 2004

Wyniki wyszukiwania

Cellular components of the bronchoalveolar lavage correlate with lung function impairment and extrapulmonary involvement markers in active sarcoidosis

Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax – malaria in India and Saudi Arabia