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Occurrence of obstructive sleep apnea in a group of shift worked police officers

75%
Shift work is an important source of health disturbances. Night work has a negative influence on some spheres: biological, working, social, and medical. Disturbances of sleeping, one group of manifestations of medical problems, can be considered as a cause of health deterioration. This study focuses on the occurrence of breathing disturbances during sleep in shift workers. Twenty one shift worked police officers (40-60 years old) were compared with an age-matched control group operating in the some environment. All subjects underwent overnight polysomnography. The polysomnographic investigation by shift workers was conducted after a day shift and normal night sleep, after an adaptational night in the sleep laboratory. Obstructive sleep apnea was found in 8 shift workers (38%) with AHI of 5.72-45.45 and in 8 control volunteers (38% of the studied group) with AHI of 5.00-25.24. All breathing parameters, as measured by polysomnography, did not differ between the two groups. Our results do not confirm the hypothesis that chronic irregular work hours promote the occurrence of obstructive sleep apnea in subjects aged 40-60 years.
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Sleep study in patients with overweight and obesity

75%
Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by repetitive collapse of the pharyngeal airway during sleep, which leads to oxygen desaturation, sleep fragmentation and daytime somnolence. Obesity is one of the most important risk factor for the development of OSAS. The exact mechanisms responsible for the relationship between obesity and OSAS are still unclear. The fat deposits in the pharynx region as well as the reduction in the lung volume have been considered as factors that might be responsible for the increase of the upper airway collapsibility. The aim of our study was to evaluate the correlation between the Body Mass Index (BMI) and sleep study parameters in overweight and obese patients suffering from breathing disturbances during sleep. We studied a group of 106 consecutive obese or overweight patients with a primary complaint of snoring or other breathing disturbances during sleep. In all cases, BMI and sleep studies (PolyMESAM) were examined. We evaluated relationship between the BMI and sleep study parameters such as Respiratory Disturbance Index (RDI), Apnea Index (AI), Desaturation Index (DI) and Average of Lowest Saturation (LSAT). The results showed the lack of significant statistical correlations between BMI and all the sleep parameters studied in the overweight patients and the statistical positive correlation between the BMI and RDI in the obese cases. We conclude that BMI determination may be considered as a simple, yet important predictor, of the OSAS in the group of obese patients.
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The influence of age and gender on the latency of eye movement in healthy humans

63%
Standard measures of sleep recordings give differing results depending on the gender and they constantly change with age. Sleep latency increases, delta sleep decreases, and sleep tend to be shorter in duration and fragmented in middle-aged and elderly adults. The deterioration of sleep is observed earlier in men. In the 1980s, new measures called the Latency of Eye Movement (LEM) and the Mean Latency of Eye Movement (M-LEM) were proposed. Previous studies have shown that untreated patients with endogenous depression had the LEM and M-LEM shortened and that both indices get prolonged during treatment with antidepressants. On the other side, alcoholics in the abstinence period have LEM and M-LEM twice as long as healthy controls. In this study we set out to compare LEM and M-LEM in healthy humans according to the gender and age. The subjects of the study were 80 healthy volunteers: 40 males and 40 females, who were divided into 4 groups: females and males, below and above 40 years of age. In contrast to standard measures, our study did not reveal any significant changes of LEM or M-LEM due to the gender or age.
K-complexes - phenomena occurring in sleep EEG - pose severe challenges in terms of detection as well as finding their physiological origin. In this study, K-complexes (KCs) were evoked by auditory stimuli delivered during sleep. The use of evoked KCs enables testing the sleeping nervous system under good experimental control. This paradigm allowed us to adopt into the KC studies a method of signal analysis that provides time-frequency maps of statistically significant changes in signal energy density. Our results indicate that KCs and sleep spindles may be organized by a slow oscillation. Accordingly, KCs might be evoked only if the stimulus occurs in a certain phase of the slow oscillation. We also observed middle-latency evoked responses following auditory stimulation in the last sleep cycle. This effect was revealed only by the time-frequency maps and was not visible in standard averages.
Background. The transition from high school to college is an important milestone in the life of adolescents. In this stage of life, they are already aware of their responsibility for their health, which allows them to develop their health habits. The aim of this study was to increase the knowledge about selected aspects of female university students’ lifestyle, including sports, sleep, stress, alcohol and smoking. Material and methods. This cross-sectional research was carried out with 1,055 female university students in their first year of study at two universities in Slovakia as part of the VEGA grant project no. 1/0825/17 “Recommendations for physical activities in prevention and control of non-communicable diseases and their implementation in the Eastern part of Slovakia” implemented at P.J. Šafárik University in Košice. Data was collected on lifestyle factors, including frequency and regularity of participating in sports during the preceding half year, by means of a questionnaire. Results. Students of both universities reported low levels of engagement in sport activity in the preceding six months, in terms of frequency and regularity of its weekly performance. There appeared to be a statistically significant relationship between the frequency of sport activity and fatigue after waking. Other relationships were not found to be statistically significant. Conclusions. The scope of educational work by university education experts should include appropriate ways of influencing the lifestyle of first-year university students towards maintaining their good health. This can be carried out within the context of health education during compulsory and optional physical education classes.
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The incidence of sleep apnea in patients with stroke or transient ischemic attack

51%
Disorders of breathing during sleep are defined as cessation or reduction of air flow thorough the upper airway, accompanied by a decrease of oxygen saturation. The results of many studies underline the association between sleep-disordered breathing (SDB) and cerebrovascular disorders. SDB, mostly obstructive sleep apnea syndrome (OSAS), is believed to be an independent risk factor of stroke and is related to poor outcome and increased long-term stroke mortality. The present study evaluated the frequency of SDB in patients with stroke or transient ischemic attack transient ischemic attack. We studied 43 patients (mean age 68.5 ±11.0), which included 35 males and 8 females, with acute stroke (n=37) and transient ischemic attack (n=6). The assessment included body mass index (BMI), age, cardiovascular risk factors, and localization of stroke. All patients underwent all-night screening for SDB with a portable 8-channel recorder. The apnea/hypopnea index (AHI) for the whole group was 13.3 ±15.2. AHI <5 was found in 16 patients. Overall, SDB was present in 27 (62.8%) patients with stroke and transient ischemic attack, stratified into those with AHI 5-10, (10 patients), 10-20 (8 patients), and AHI>20 (9 patients). In 15 patients, there was an increase in AHI 5 on assuming the supine position. The patients’ mean BMI was 27.8 ±4.7. The analysis of BMI, age, and localization of stroke was not sufficient to identify patients with high risk for SDB. We submit that overnight screening for SDB should be routinely performed in every patient after stroke and transient ischemic attack and it should become a diagnostic tool in neurological departments.
The aim of our study was to characterize the dynamics of heart rate variability (HRV) during sleep in healthy subjects and in patients with obstructive sleep apnea syndrome (OSAS). Present results were compared with earlier data obtained in healthy subjects (1) performing intermittent voluntary apneas. Power spectra in low (LF) and high (HF) frequency band and non linear indices: correlation dimension (CD) and recurrence plots were computed. New indices were applied: a beat-to beat control (BBC) for the assessment of cardiovascular regulatory mechanisms as cardiac, vascular or mixed type control and COT for quantification of relative contribution of cardiac and vascular component in blood pressure variability. During Wake stage in OSAS patients mean LF component was augmented (0.035 s2/Hz) comparing to healthy subjects (0.012 s2/Hz). Nonlinear indices suggest reduced HRV dynamics complexity in OSAS patients. Similar pattern could be observed when comparing LF component, CD and recurrence parameters during spontaneous breathing and in consecutive voluntary apneas. The results correlate with 20% increase in BBC vascular control type and COT inversion form +0.08 to - 0.12. Changes in BBC and COT along with power spectra and nonlinear dynamics indices appear to signal risk and/or initiation of arterial hypertension in OSAS patients.
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