Trace elements are important in appropriate organisms functioning. Among them manganese as well as silicon play essential roles. Manganese takes parts in composition of many enzymes, it is a cofactor of numerous enzymatic reactions, a structural element of skin and bones, it also prevents osteoporosis. Its very important role in reproduction processes and in central nervous system has been already stated. Silicon is a very important factor, which takes active part in vital processes, regenerating tissues and increasing general immunity of organism. It has basic meaning in metabolism of connective tissue, collagen formation and bone development and mineralization, cartilages, hair, nails, teeth in human and animals, and also in processes of convalescence and ageing of organism. The aim of our experiment was to estimate influence of manganese chloride on the concentration of silicone in mice tissues. It has been find out that doses of administered manganese as well as the duration of exposure have influence on silicon content in tissues.
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