Wyniki wyszukiwania

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Role of nitrergic and endothelin pathways modulations in cisplatin-induced nephrotoxicity in male rats

100%

Helmy M. W., Helmy M. M., Abd Allah D. M., Abo Zaid A. M., Mohy El-Din M. M.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 3

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Effects of phosphodiesterase 5 inhibitor sildenafil on the respiratory parameters, inflammation and apoptosis in a saline lavage-induced model of acute lung injury

100%

Kosutova P., Mikolka P., Balentova S., Kolomaznik M., Adamkov M., Mokry J., Calkovska A., Mokra D.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 5

3

Sildenafil, a phosphodiesterase type 5 inhibitor, downregulates osteopontin in human peripheral blood mononuclear cells

100%

Kaleta B., Boguska A.

Archivum Immunologiae et Therapiae Experimentalis

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2017

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tom 65

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nr 4

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Long-term effects of early administered sildenafil and NO donor on the cardiovascular system of SHR

80%

Kristek F., Koprdova R., Cebova M.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 1

We evaluated the long-term effect of NO-donor, pentaerythrityl tetranitrate (Petn), and sildenafil citrate (sildenafil) on the cardiovascular system of the spontaneously hypertensive rat (SHR). Petn (100 mg/kg/day) and sildenafil (10 mg/kg/day) were administered to SHR individually or together from week 4 (pre-hypertensive period) to week 9 of age. Blood pressure (BP) was measured using a plethysmographic method. The animals were perfused with a glutaraldehyde fixative (120 mmHg). Carotid (AC) and coronary artery (RS) were processed according to electron microscopy procedure. Geometry of the arteries was measured on semi-thin sections using light microscopy. Administration of Petn and sildenafil to SHR individually or together did not prevent an increase of BP, but evoked a decrease of cardiac hypertrophy. Petn and sildenafil affected the geometry of RS and AC differently. In the RS, an increase of inner diameter (ID) without an increase of wall thickness (WT) resulted in increased WT/ID and circumferential stress. In the AC, changes in ID were accompanied by changes in WT and, thereby, WT/ID and circumferential stress remained unchanged. The arterial wall mass of both arteries was increased. The data suggest that administration of the NO donor, Petn, and/or sildenafil does not result in a beneficial effect on the myocardium or on the geometry of the carotid and coronary arteries.

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

1 Archivum Immunologiae et Therapiae Experimentalis

1 Abd Allah D. M.

1 Abo Zaid A. M.

1 Adamkov M.

1 Balentova S.

1 Boguska A.

1 Calkovska A.

1 Cebova M.

1 Helmy M. M.

1 Helmy M. W.

1 Kaleta B.

1 Kolomaznik M.

1 Koprdova R.

1 Kosutova P.

1 Kristek F.

1 Mikolka P.

1 Mohy El-Din M. M.

1 Mokra D.

1 Mokry J.

1 2018

1 2017

1 2014

1 2007

Role of nitrergic and endothelin pathways modulations in cisplatin-induced nephrotoxicity in male rats

Effects of phosphodiesterase 5 inhibitor sildenafil on the respiratory parameters, inflammation and apoptosis in a saline lavage-induced model of acute lung injury

Sildenafil, a phosphodiesterase type 5 inhibitor, downregulates osteopontin in human peripheral blood mononuclear cells

Long-term effects of early administered sildenafil and NO donor on the cardiovascular system of SHR