Wyniki wyszukiwania

1

Animal models of schizophrenia: developmental preparation in rats

100%

Ratajczak P., Wozniak A., Nowakowska E.

Acta Neurobiologiae Experimentalis

|

2013

|

tom 73

|

nr 4

Schizophrenia manifests itself primarily with positive symptoms, negative symptoms and cognitive disorders. Animal models of mental diseases seem to be an important tool in understanding key theories related with pathophysiology of the disorder and are used to assess efficacy of new drugs. References describe four basic groups of animal models of schizophrenia, such as: models created by pharmacological intervention, genetic models, lesion models and models of developmental disorders of primary brain structures. Of the models referred to above, the group of developmental disorder models is particularly noteworthy, as they are primarily easy to use, and the methods are highly sensitive. High scientific value of these models is associated with the neurodevelopmental theory which stipulates that at an early stage of body development, a number of interactions between genetic and environmental factors may affect the development of neurons which may cause disorders of brain cytoarchitecture development.We review six developmental models of schizophrenia in rats (MAM - methylooxymethanol acetate, prenatal stress, maternal deprivation, isolation rearing, prenatal immune challenge and maternal malnutrition) that are all validated by disruption in PPI.

2

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

The quality of life in patients with schizophrenia in community mental health service - selected factors

100%

Makara-Studzinska M., Wolyniak M., Partyka I.

Journal of Pre-Clinical and Clinical Research

|

2011

|

tom 05

|

nr 1

3

Does electroconvulsive therapy [ECT] affect cognitive components of auditory evoked P300?

100%

Griskova I., Dapsys K., Andruskevicius S., Ruksenas O.

Acta Neurobiologiae Experimentalis

|

2005

|

tom 65

|

nr 1

4

Pathology and compensation during visual signal processing in schizophrenia-spatial analysis of event-related potentials

100%

Basinska-Starzycka A.

Acta Neurobiologiae Experimentalis

|

2000

|

tom 60

|

nr 3

5

Obstetric complications, age of parents and a risk for schizophrenia

84%

Karakula H., Pawezka J., Grzywa A., Urbanska A., Szajer K., Sekunda A., Spila B., Wysocka A.

Polish Journal of Environmental Studies

|

2004

|

tom 13

|

nr Suppl.2, Part 1

Schizophrenia is an etiologically complex disorder arising from the interactions between and a range of factors acting at various stages in life. Despite the 70 year history in scientific literature describing the correlation between obstetric complications as a risk factor for schizophrenia it is still the subject of many research studies. A relatively new trend in research is to analyze the ages of the mother, father and the occurrence of this disease. The aim of this research, based on a review of literature, was to present the current level of knowledge relating to these topics while taking into account the factors for three groups of obstetric complications: I - complications during pregnancy (preeclampsia, bleeding, diabetes, rhesus incompatibility, hypertension with diuretic treatment); II - abnormal fetal development (low birth weight, congenital malformations, reduced head circumference); and III - complications during delivery (uterine atony, asphyxia, emergency Cesarean section).

6

Generation of membrane-bound catechol-O-methyl transferase deficient mice with distinct sex dependent behavioral phenotype

84%

Tammimaki A., Aonurm-Helm A., Zhang F. P., Poutanen M., Duran-Torres G., Garcia-Horsman A., Mannisto P. T.

Journal of Physiology and Pharmacology

|

2016

|

tom 67

|

nr 6

7

Do the asymmetry and the size of the structures of the temporal lobe persist in early stages of schizophrenia?

84%

Morys J. M., Dziewiatkowski J., Bobek-Billewicz B., Ratajczak I., Narkiewicz O., Morys J.

Folia Morphologica

|

2004

|

tom 63

|

nr 4

A total of 14 patients of various ages diagnosed with schizophrenia and, as an age-matched control group, 12 healthy subjects were examined using the MRI method of neuro-imaging. The volume of the following structures was evaluated in the right and left hemispheres: the superior temporal gyrus, the basolateral temporal area (the region including the middle temporal gyrus, inferior temporal gyrus and fusiform gyrus), the parahippocampal gyrus, the hippocampal head, the amygdaloid body and the inferior horn of the lateral ventricle. In schizophrenia a significant increase in the volume of the amygdaloid body on both the left and right sides was observed. In the patients, as in the control group, we noticed significant asymmetry between the left and right sides in the volume of the structures studied. The left amygdaloid body was significantly larger than the right, whereas the left hippocampal head and the temporal horn of the lateral ventricle were smaller than the right. Our findings suggest that in the early stages of schizophrenia, despite the increased volume of the amygdaloid body, the asymmetry between the structures of the temporal lobe is still present. However, the changes observed in the temporal lobe could be related to the functional disturbances observed in this disease.

8

Neuroleptics modulate cytokine and reactive oxygen species production in blood leucocytes of healthy volunteers

84%

Szuster-Ciesielska A., Slotwinska M., Stachura A., Marmurowska-Michalowska H., Kandefer-Szerszen M.

Archivum Immunologiae et Therapiae Experimentalis

|

2004

|

tom 52

|

nr 1

9

Altered electrophysiological pattern of target detection in schizophrenia in the Continuous Attention Test

84%

Basinska A.

Acta Neurobiologiae Experimentalis

|

1998

|

tom 58

|

nr 3

10

Blockade on NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats

84%

Wedzony K., Fijal K., Chocyk A.

Journal of Physiology and Pharmacology

|

2005

|

tom 56

|

nr 2

Malfunction of glutamatergic neurotransmission in postnatal period is considered to be a risk factor for development of schizophrenia. Thus, the present study investigates the impact of NMDA receptor blockade in the postnatal period on the density of tyrosine hydroxylase immunoreactive axonal arbors in the rat medial prefrontal cortex. Behavioral experiments revealed that adult rats (60 days old) treated in the postnatal period with a competitive antagonist of NMDA receptors, CGP 40116 (1.25 mg/kg on days 1, 3, 6, 9; 2.5 mg/kg on days 12, 15, 18; and finally 5 mg/kg on day 21, all injections s.c.), showed enhancement of the locomotor activity stimulated by quinpirole (0.3 mg/kg s.c.) and amphetamine (0.5 mg/kg s.c.), which suggests development of functional supersensitivity of dopaminergic systems. It has been found that CGP 40116, given in postnatal period decreased the density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult animals. The decrease was observed in superficial (II/III) and deep (V/VI) layers of the medial prefrontal cortex, while the average length of tyrosine hydroxylase immunoreactive axonal arbors was increased in both superficial and deep cortical layers. Changes in the density of tyrosine hydroxylase immunoreactive axonal arbors have not been followed by a significant decrease in the content of tyrosine hydroxylase protein measured by Western blot. Thus, NMDA receptor blockade in the early period of life evokes changes in architecture of tyrosine hydroxylase immunoreactive axonal arbors and that malfunction of glutamatergic neurotransmission, in early period of life may produce anatomical changes which resemble those observed in the brains of schizophrenics.

11

Evaluation of new MMN parameters in schizophrenia

84%

Korostenskaja M., Dapsys K., Maciulis V., Ruksenas O.

Acta Neurobiologiae Experimentalis

|

2003

|

tom 63

|

nr 4

12

Comparative post-mortem study of cavum septi pellucidi in alcoholics, schizophrenics and aggressive persons

84%

Filipovic B., Teofilovski-Parapid G., Stojicic M.

Folia Morphologica

|

1999

|

tom 58

|

nr 4

The appearance of cavum septi pellucidi (CSP) has been already connected with developmental disorders or with serious psychiatric diseases (schizophrenia, maniac-depressive disorder; aggressiveness or similar). During our investigation of CSP, group of alcoholics seemed to be interesting for investigation and comparison with the groups of schizophrenics and people with violent behavior: We obtained CSP in 205 out of 670 fixed brains (429 male and 241 female) of persons aged from l4 to 89 (mean ~ SD: 53.28 ~16.57), 85 cava belonged to our group of interest. Prevalence of CSP in aforementioned groups was significantly higher than in the rest of examined population. Only in the group of 20 to 39 years of age all kinds of obtained pathologies were present. Alcoholics with CSP suffered from cardiovascular diseases and died accidentally and aggressive persons were the only drug addicts in our examined group and they had the shortest life span. 34 out of 4l schizophrenics had no data about prior diseases and disorders and they were the ones who committed suicide frequently. Intensive demyelinization of corpus callosum and transformation of potential space between laminae of septum pellucidum to the actual one could explain the CSP appearance among alcoholics. To our opinion, cavum septi pellucidi might be used as an additional marker of organic brain changes in long term alcohol abuse, as a consequence of demyelinization due to lipolytic effect of ethanol, and lower cerebral blood flow.

13

Perception of facial affect in chronic schizophrenia and right brain damage

84%

Kucharska-Pietura K., Klimkowski M.

Acta Neurobiologiae Experimentalis

|

2002

|

tom 62

|

nr 1

14

Importance of cannabinoids in the functioning of the central nervous system

67%

Wroblewska-Luczka P., Florek-Luszczki M., Luszczki J. J.

Health Problems of Civilization

|

2018

|

tom 12

|

nr 3

At present, there is a great emphasis of public opinion on the legalisation of medical marijuana, i.e. the top parts of the cannabis plants rich in tetrahydrocannabinol (THC). Nevertheless, in the cannabis plants, there are many various cannabinoids, including cannabidiol (CBD). Scientific reports to-date indicate the possibility for using pharmacologically active cannabinoids in the treatment of such diseases/symptoms as: anorexia, vomiting, neuropathic pain, inflammatory diseases, multiple sclerosis, degenerative diseases of the central nervous system (Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, Tourette’s syndrome), epilepsy, schizophrenia, and obesity. The article presents up-to-date information on the results of experimental studies concerning the effectiveness of cannabinoids, with particular consideration of diseases related with the central nervous system, including epilepsy, neuropathic pain, mental disorders, as well as obesity and anorexia.

15

Social isolation-induced epigenetic changes in midbrain of adult mice

67%

Siuda D., Wu Z., Chen Y., Guo L., Linke M., Zechner U., Xia N., Reifenberg G., Klienert H., Forstermann U., Li H.

Journal of Physiology and Pharmacology

|

2014

|

tom 65

|

nr 2

16

SNARE proteins and schizophrenia: linking synaptic and neurodevelopmental hypotheses

67%

Johnson R. D., Oliver P. L., Davies K. E.

Acta Biochimica Polonica

|

2008

|

tom 55

|

nr 4

619-628

Much of the focus of neurobiological research into schizophrenia is based on the concept that disrupted synaptic connectivity underlies the pathology of the disorder. Disruption of synaptic connectivity is proposed to be a consequence of both disrupted synaptic transmission in adult hood and abnormalities in the processes controlling synaptic connectivity during development of the central nervous system. This synaptic hypothesis fits with neurodevelopmental models of schizophrenia and our understanding of the mechanisms of antipsychotic medication. This conceptual model has fostered efforts to define the exact synaptic pathology further. Synaptic proteins are obvious candidates for such studies, and the integral role of the SNARE complex, and SNARE-associated proteins, in synaptic transmission will ensure that it is the focus of much of this research. Significant new insights into the role of this complex are arising from new mouse models of human disease. Here the evidence from both animal and human clinical studies showing that the SNARE complex has a key role to play in the aetiology and pathogenesis of schizophrenia is discussed.

17

Analysis of the antibodies anti-Toxoplasma gondii by ELISA based on two diagnostic antigens: rSAG1 and rBAG1

67%

Liu M., Wang T., Li H., Li J.-Y., Zhong H., Tan C.-Z., Huang D.-C., Zhao L., Chen X.-G., Lun Z.-R.

Acta Parasitologica

|

2011

|

tom 56

|

nr 4

Schizophrenia is a serious neuropsychiatric disease of uncertain etiology. Previous studies have demonstrated that antibodies to Toxoplasma gondii infection are associated with an increased risk of schizophrenia. The objective of this study was to analyze anti-T. gondii antibodies in 477 Chinese schizophrenia patients using an enzyme-linked immunosorbent assay (ELISA) based on recombinant surface antigen 1 (rSAG1), recombinant bradyzoite antigen 1 (rBAG1) and the soluble tachyzoite antigens (STAg) of T. gondii RH strain. Results showed that among the sero-positives (IgG and/or IgM) for T. gondii infection examined in schizophrenia patients, sero-positive samples for rSAG1, rBAG1 and STAg were 20.5% (98/477), 20.5% (98/477) and 23.5% (112/477) respectively, while compared to 210 blood donors, sero-positive (IgG and/or IgM) samples for these antigens (rSAG1, rBAG1 and STAg) were only 5.7% (12/210), 6.2% (13/210) and 5.7% (12/210), respectively. Furthermore, when IgG antibody reaction in the schizophrenia sera was compared with the rBAG1 and rSAG1, results demonstrated that beside the cases which can be detected by both rSAG1 and rBAG1, some sero-positive for T. gondii in schizophrenia sera can only be detected either by rSAG1 or rBAG1. This phenomenon was also observed in the detection of IgM with rSAG1 and rBAG1. 5.9% (28/477) of cases of schizophrenia which are positive for IgG or IgM by rSAG1 are negative for STAg, while 9.2% (44/477) of the schizophrenia cases which are positive for IgG or IgM by rBAG1 are negative for STAg. Although STAg can also be used to diagnose T. gondii infection from schizophrenia patients, it may not actually indicate the infection as some positive samples may be mistakenly considered to be negative. In conclusion, our results demonstrate that the sero-positive rate for T. gondii in the Chinese schizophrenia patients was higher than blood donors. More importantly, our results provide evidence that the combination of rSAG1 and rBAG1 antigens in the diagnosis of T. gondii infection could closely reflect the actual infection of this parasite in schizophrenia patients.

18

Chlorpromazine exerts stronger suppressive action on the instrumental responses motivated by social than by alimentary reward

67%

Fonberg E.

Acta Neurobiologiae Experimentalis

|

1992

|

tom 52

|

nr 2

19

Muscle rigidity induced by fluphenazine in rats is antagonized by L-DOPA, an antiparkinsonian drug

67%

Ossowska K., Konieczny J., Lorenc-Koci E., Schulze G., Coper H., Wolfarth S.

Journal of Physiology and Pharmacology

|

1998

|

tom 49

|

nr 2

20

Characterization of CCK receptor - mediated effects on intracellular calcium of porcine chief cells

67%

Heim H. K., Elhoft A., Wittstock H., Sewing K. F.

Journal of Physiology and Pharmacology

|

1995

|

tom 46

|

nr 4

Ograniczanie wyników

Animal models of schizophrenia: developmental preparation in rats

The quality of life in patients with schizophrenia in community mental health service - selected factors

Does electroconvulsive therapy [ECT] affect cognitive components of auditory evoked P300?

Pathology and compensation during visual signal processing in schizophrenia-spatial analysis of event-related potentials

Obstetric complications, age of parents and a risk for schizophrenia

Generation of membrane-bound catechol-O-methyl transferase deficient mice with distinct sex dependent behavioral phenotype

Do the asymmetry and the size of the structures of the temporal lobe persist in early stages of schizophrenia?

Neuroleptics modulate cytokine and reactive oxygen species production in blood leucocytes of healthy volunteers

Altered electrophysiological pattern of target detection in schizophrenia in the Continuous Attention Test

Blockade on NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats

Evaluation of new MMN parameters in schizophrenia

Comparative post-mortem study of cavum septi pellucidi in alcoholics, schizophrenics and aggressive persons

Perception of facial affect in chronic schizophrenia and right brain damage

Importance of cannabinoids in the functioning of the central nervous system

Social isolation-induced epigenetic changes in midbrain of adult mice

SNARE proteins and schizophrenia: linking synaptic and neurodevelopmental hypotheses

Analysis of the antibodies anti-Toxoplasma gondii by ELISA based on two diagnostic antigens: rSAG1 and rBAG1

Chlorpromazine exerts stronger suppressive action on the instrumental responses motivated by social than by alimentary reward

Muscle rigidity induced by fluphenazine in rats is antagonized by L-DOPA, an antiparkinsonian drug

Characterization of CCK receptor - mediated effects on intracellular calcium of porcine chief cells