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Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol

100%

Kurnik M., Gil K., Gajda M., Thor P., Bugajski A.

Folia Histochemica et Cytobiologica

2015

tom 53

nr 1

Peripheral mechanisms of intestinal dysmotility in rats with salsolinol induced experimental Parkinson's disease

100%

Banach T., Zurowski D., Gil K., Krygowska-Wajs A., Marszalek A., Thor P. J.

Journal of Physiology and Pharmacology

2006

tom 57

nr 2

Gastrointestinal dysmotility in Parkinson's disease (PD) has been attributed in part to peripheral neurotoxine action. Our purpose was the evaluation of the salsolinol effect on intramuscular interstitial cells of Cajal (ICC), duodenal myoelectrical activity (DMA) and vagal afferent activity (VAA) in rats with experimental PD. Twenty rats were divided into 2 equal groups. Experimental PD was produced in one group by 3 weeks of the intraperitoneal salsolinol injections (50 mg/kg/day), whereas the 2-nd group served as control. DMA and VAA were recorded in both groups during fasting and stepwise - gastric distension (GD) of 10 ml. Subsequently fragments of duodenum were removed and intramuscular ICC were assessed as c-Kit antigen percentage in the duodenal muscular zone. Analyses of the fasting DMA and VAA recordings didn't reveal differences between the compared groups. During GD increase of DMA dominant frequency (p=0.04) and VAA frequency (p<0.01) was observed in the controls whereas in the salsolinol group both parameters remained unchanged. Image analysis of duodenum revealed decreased c-Kit expression in the salsolinol-injected animals (p=0.05). The results of our study may suggest the direct effect of salsolinol on both ICC and neuronal pathways of gastro-duodenal reflexes.

Prolactin and the physiological regulation of its secretion. A review

80%

Ciechanowska M., Misztal T., Przekop F.

Journal of Animal and Feed Sciences

2013

tom 22

nr 2

This review briefly summarizes recent findings on lactotrophs in the pituitary gland and extrapituitary tissues as a no homologous group cell types of different embryonic origin, morphology and biological function. They display a remarkable adaptation to altered physiological condition. Their functions are derived from structural polymorphism, local synthesis, divergent intracellular signaling pathways and target genes. Most of them are heterogenous with respect to basal hormone release, electrical activity and responsiveness to stimulatory/inhibitory factors, depending upon gender and physiological state of animal. The circulating prolactin (PRL) produced by many types of lactotrophs can act in edocrine/paracrine/autocrine manner, respectively as a hormone, growth factor, neurotransmitter or immunoregulator. At the cellular level PRL exerts mitogenic, morphogenic and secretory activity. Numerous factors of the central and peripheral origin are involved in the mechanism regulating PRL secretion, causing an increase or decrease of the hormone concentration in the circulation. The certain feedback mechanism keep the pituitary lactotrophs to be not overactive

Ograniczanie wyników

1 Folia Histochemica et Cytobiologica

1 Journal of Animal and Feed Sciences

1 Journal of Physiology and Pharmacology

2 Gil K.

1 Banach T.

1 Bugajski A.

1 Ciechanowska M.

1 Gajda M.

1 Krygowska-Wajs A.

1 Kurnik M.

1 Marszalek A.

1 Misztal T.

1 Przekop F.

1 Thor P.

1 Thor P. J.

1 Zurowski D.

1 2015

1 2013

1 2006

Wyniki wyszukiwania

Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol

Peripheral mechanisms of intestinal dysmotility in rats with salsolinol induced experimental Parkinson's disease

Prolactin and the physiological regulation of its secretion. A review