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1

Wpływ antagonisty glutaminianergicznego receptora metabotropowego mGluR1 na aktywność czepco-żwacza w teście doświadczalnego rozciągania ściany okrężnicy u owcy

100%
Kania B. F., Wielgosz M.
Medycyna Weterynaryjna
|
2013
|
tom 69
|
nr 09
The aim of this study was defining relationships between a five minute episode of mechanical colonic distensions (CD) of different degrees, which were provoked by the insertion of a balloon filled with 150 and/or200 ml of water (CD150 and/or CD200), and reticulo-ruminal motility changes, heart rate, respiration frequency as vegetative symptoms of the nociceptive effects. Futhermore, noting the influence of premedication by metabotropic glutamate receptor antagonist DL-AP3 i.c.v. 1 min. infusion in 3 different doses (4.0, 8.0 and 12.0 mg in toto) on the above symptoms in sheep. The experiment was carried out in 4 series using 12 female sheep, Polish Merinos with fistula of dorsal sac of the rumen, in the anoestrus period. In the first series (6 animals as a control group) the animals had a 200 ml 0.9% NaCl i.c.v. infusion. In the second series (6 animals) they had a 5 min episode of CD by insertion of a balloon filled with 150 and/or 200 ml of water (CD150 and/or CD200). In the third series of the experiment 6 animals had an i.c.v. DL-AP3 infusion in 3 different doses (4.0, 8.0 or 12.0 mg in toto), every week. In the fourth series, the animals had i.c.v. DL-AP3 infusions in 3 different doses (4.0, 8.0 or 12.0 mg in toto) ten minutes before CD. CD espisodes of five min duration provoke a very repetitive, statistically significant increase of heart rate/ min, reticulo-ruminal motility inhibition, and nociceptive symptoms intensivity, and this can be a new model for testing potential analgesic substances and drugs for small ruminants. DL-AP3 racemate, a metabotropic glutamate receptor mGluR₁ antagonist, can be an alternative drug in jejunal pain when it is provoked by colonic distension in sheep.
2

Wpływ doświadczalnego rozciągania ściany okrężnicy na neurofizjologiczne parametry bólu

80%
Kania B. F., Debski B., Piastowicz-Ciesielska A.
Medycyna Weterynaryjna
|
2012
|
tom 68
|
nr 08
The aim the study was to define the relationships between a five-minute episode of mechanical colon distension (CD) of different degrees caused by the insertion of a balloon filled with 150 or 200 ml of water (CD 150 or CD 200) and neuroendocrine plasma levels (E, NE, DA, cortisol), as well as behavioural and clinical symptoms (reticulo-ruminal motility, heart rate, respiration frequency) as vegetative symptoms of nociceptive effects. Experiments were carried out on 12 female sheep, Polish merinos, in the anoestrus period. A five-minute episode of CD caused a highly repetitive, statistically significant increase in E, NE, DA, and cortisol plasma concentrations, as well as a reticulo-ruminal motility decrease (viscero-visceral inhibitory reflex) and nociceptive behavioural symptoms (looking around, defecation and/or urination, stretching, bleating). Practically all of these symptoms, which were easy to observe and quantify, recurred in animals suffering from colon distension, but their intensity was lower than in the case of e.g. duodenal distension. This suggests that this model of colic is less painful to animals. This less invasive in vivo method might be useful for the testing of analgesics and their antinociceptive effects in small ruminants.
3

Analiza porównawcza wpływu dwóch form antagonisty receptora glutaminianergicznego (mGluR) grupy I na stężenie katecholamin w ostrym bólu jelitowym u owcy

80%
Kania B. F., Wronska D.
Medycyna Weterynaryjna
|
2015
|
tom 71
|
nr 08
The aim of this study was a comparative analysis between a five minute episode of mechanical colonal descending distension, which was provoked by the insertion of a balloon filled with 200 ml of water (CD200), and plasma CA concentration (epinephrine E, norepinephrine – NE and dopamine – DA) changes as a consequence of the sympatho-medullary-adrenal axis stimulation as well as nociceptive/stressoric effects. Furthermore, to note the comparative influence of premedication by metabotropic glutamate receptor antagonists by L-isomer (L-AP3) in the doses of 0.2, 0.4 and/or 0.8mg in toto and/or DL-AP3 racemate i.c.v. one min infusion in three different doses (4.0, 8.0 or 12.0 mg in toto) on the plasma CA concentration changes during 120 min of experimentation. The experiment was carried out in four series using 12 female sheep, Polish Merinos, in the anoestrus period (May–June). In the first series (six animals as a control group) the animals had a 200 μl 0.9% NaCl i.c.v. infusion. In the second series (six animals) they had a five min episode of CD by insertion of a balloon filled with 200 ml of water (CD200). In the third series of the experiment six animals had an i.c.v. DL-AP3 or L-AP3 infusion in three different doses (4.0, 8.0 or 12.0 and 0.2, 0.4 or 0.8 mg in toto, respectively), while in the fourth series, ten minutes before CD200, every week. Colon descending distension episodes lasting five min provoke a very repetitive, statistically significant increase of plasma CA concentration, a critical indicator – after cortisol – of the consequent stressoric effect of the sympatho-medullary adrenal axis stimulation. As a metabotropic nonspecific glutamate receptor type-1 antagonists DL-AP3 racemate and L-isomer AP3 certainly attenuate this elevation of CA, and can be an alternative drug in colonal pain caused by their wall having been distended in sheep. Clinical application of this AP3 must be confirmed by peripheral administration of the drugs.
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