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1

Ghrelin-immunoreactive cells in the gastrointestinal tract of hypertensive rats

100%
Janiuk I., Kaleczyc J., Kasacka I.
Folia Histochemica et Cytobiologica
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2016
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tom 54
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nr 4
2
Content available remote

Regular exercise alleviates renovascular hypertension-induced cardiac/endothelial dysfunction and oxidative injury in rats

84%
Kumral Z. N. O., Sener G., Ozgur S., Koc M., Suleymanoglu S., Hurdag C., Yegen B. C.
Journal of Physiology and Pharmacology
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2016
|
tom 67
|
nr 1
3
Content available remote

Losartan metabolite EXP3174 reduces the weight of formed thrombus in 2K1C hypertensive rats

84%
Gromotowicz-Poplawska A., Nazarko-Sadowska J., Chabielska E.
Journal of Physiology and Pharmacology
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2019
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tom 70
|
nr 3
4
Content available remote

Myrtus communis improves cognitive impairment in renovascular hypertensive rats

67%
Cevikelli-Yakut Z.-A., Ertas B., Sen A., Koyuncuoglu T., Yegen B. C., Sener G.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 5
5
Content available remote

Quantitative distribution and localization of calcitonin gene-related peptide-like cells in the stomach of two kidney, one clip rats

67%
Kasacka I.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 2
35-39
The majority of research for the calcitonin gene-related peptide (CGRP) in the stomach in the hypertension has been devoted to the submucosal blood flow, and no attention has been paid to its quantitative distribution in the gastric neuroendocrine cells. The aim of the present study was to examine the number and distribution of CGRP-containing cells in the pylorus of “two kidney, one clip” (2K1C) renovascular hypertension model in rats. The studies were carried out on the stomach of rats. After 6 week period of the renal artery clipping procedure, eight 2K1C rats developed stable hypertension. The hypertension significantly increased the number of endocrine cells pylorus immunoreactive to calcitonin gene-related peptide (CGRP) antisera. The differences between the hypertensive rats and the control group concerned not only the number of endocrine cells but also their distribution. CGRP participates in the regulation of cardiovascular functions both in normal state and in the pathophysiology of hypertension through interactions with the prohypertensive systems. The changes induced by hypertension in the neuroendocrine cells containing CGRP of the rats are discussed.
6
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The adrenal renal vascular connection plays an essential role in the pathogenesis of renovascular hypertension in the rat

67%
Abramczyk P., Ziecina R., Lisiecka A., Papierski K., Przybylski J.
Journal of Physiology and Pharmacology
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2000
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tom 51
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nr 1
7
Content available remote

Altered expression of angiotensin AT1a and vasopressin V1a receptors and nitric oxide synthase mRNA in the brain of rats with renovascular hypertension

67%
Jackiewicz E., Szczepanska-Sadowska E., Dobruch J.
Journal of Physiology and Pharmacology
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2004
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tom 55
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nr 4
Previous studies revealed that the brain angiotensinergic, vasopressinergic and nitrergic systems are involved in regulation of blood pressure and that their function is altered in various forms of hypertension. The purpose of our investigation was to determine whether expression of AT1a angiotensin receptors (AT1aR) mRNA, V1a vasopressin receptors (V1aR) mRNA and neuronal nitric oxide synthase (NOS1) mRNA is altered in the brain of rats with the renovascular hypertension. Eight male Sprague Dawley (SD 2K,1C) rats were subjected to constriction of the left renal artery in order to produce the renovascular hypertension whereas nine SD rats underwent the sham surgery. In both groups blood pressure was determined before and after the surgery. Four weeks after the surgery the brain fragments were harvested for determination of mRNA expression. Competitive PCR method was applied for relative quantitative analysis of V1aR mRNA, AT1aR mRNA and NOS1 mRNA in the preoptic, diencephalic, mesencephalopontine, medullary and cerebellar fragments of the brain. Blood pressure was significantly higher in the 2K,1C than in the sham operated rats. In the preoptic, mesencephalopontine and medullary regions AT1aR mRNA expression was significantly lower in the 2K,1C rats than in the sham operated rats. The 2K,1C rats manifested also significantly higher expression of V1aR mRNA and NOS1 mRNA in the preoptic brain region in comparison to the sham operated rats. The study provides evidence for significant changes of expression of AT1aR mRNA, V1aR mRNA and NOS1 mRNA in the specific brain regions of rats with the renovascular hypertension.
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