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The study of content of K, Mg, Ca, Na, Zn, Cu, Fe, Li, and Pb in human hair was carried out on 300 individuals in the years 1996-2002. The patients were from Lublin, Zamość, Łabunie, Krasnystaw, Ostrów Krupski, and Zwierzyniec. The samples of hair to be examined for the content of Mg, K, Na, Zn, Cu, Fe, Li, and Pb were collected from 79 healthy controls, 98 mentally handicapped, 81 psychiatric patients and 42 somatic patients. The content of particular elements in hair was determined using atomic absorption spectometer type AAS-3 (Carl Zeiss), attached to a microcomputer type 113 MPC/38 C and Spectr AA 880 by Varian. The results of the study of hair revealed the positive correlation between Mg and Pb (Rs=0,49, p=0,000024) and between K and Na in healthy controls. Negative correlation was revealed between Mg and K in healthy controls and between Mg and Ca in all studied patients.
The study of blood serum for the content of Mg, K, Ca, Na, P and CI in blood serum was carried out on 47 healthy controls, 121 mentally handicapped, 27 psychiatric and 14 suffering from different somatic diseases. The patients were from Lublin, Zamość, Zwierzyniec, Krasnystaw, Łabunie, Ostrów Krupski. The study was carried out using atomie absorption spectrometer type Cobas Mira in the Central Laboratory of State Children's Hospital in Lublin. The results of the study revealed positive correlation between Mg and Ca in 47 healthy controls, similar correlation between Mg and K, Mg and P. In 162 patients correlation between Mg and P, and between Ca and P was also positive.
Presenting detailed picture of psychical problems in healthy controls and patients enabled to see indirect important effect of polyetiological determinants of metabolism of minerals in 388 subjects included in the study, whose blood serum and hair were tested for the content of magnesium, potassium, sodium, calcium, phosphorus, chlorine, zinc, copper, iron, lithium and lead. The most important factor is nutrition. The subjects, except 79 healthy controls, were fed in residential accomodation, so they received almost the same meals in their institution. Psychiatric patients and mentally handicapped received drugs from the same group - psychotropic drugs, they stayed in the same accomodation and microclimate, their lifestyle was also similar (little exercise, little fresh air) and therefore they had a limited oportunity to obtain vital elements from surrounding environment. They were not much exposed to heavy metals in their environment, so the content of lead is much lower than in the studies by other authors from more industrialized areas. In the mentally handicapped, decreased contents of magnesium and calcium were found in serum and hair, the content of copper was lower than in the controls, but the content of iron was higher. The content of potassium in serum and hair in psychiatric patients was the highest of all subjects, which may be important for diagnosis.
The content of magnesium in the blood serum or hair was determined in 88 patients using atomic spectrometry, and the content of magnesium, potassium, sodium, calcium, chlorine, phosphorus in the blood serum and magnesium, potassium, sodium, calcium, zinc, copper, iron, lithium, lead in their hair of 300 patients. When a considerable magnesium deficiency was revealed in blood serum and hair in 28 mentally handicapped males with increased aggression, restlessness, psychomotor excitation and coexisting epilepsia, a 1-month supplementation was administered, which resulted in a considerable improvement in the social functioning in 17 patients. The remaining 11 patients who did not show improvement after the first supplementation, were given the second 2-month supplementation, which resulted in the expected considerable improvement.
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