Wyniki wyszukiwania

1

Relamorelin and other ghrelin receptor agonists - future options for gastroparesis, functional dyspepsia and PPI-resistant non-erosive reflux disease

100%

Zatorski H., Mosinska P., Storr M., Fichna J.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 6

2

Role of proton pump inhibitors in preventing hypergastrinemia-associated carcinogenesis and in antagonizing the trophic effect of gastrin

84%

Man Y.-M., Park J.-M., Kangwan N., Jeong M., Lee S., Cho J. Y., Ko W. J., Hahm K. B.

Journal of Physiology and Pharmacology

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2015

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tom 66

|

nr 2

3

Prevention by lansoprazole, a proton pump inhibitor, of indomethacin-induced small intestinal ulceration in rats through induction of heme oxygenase-1

67%

Yoda Y., Amagase K., Kato S., Tokioka S., Murano M., Kakimoto K., Nishio H., Umegaki E., Takeuchi K., Higuchi K.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 3

287-294

The effect of lansoprazole, a proton pump inhibitor (PPI), on indomethacin-induced small intestinal ulceration was examined in rats, particularly in relation to heme oxygenase (HO)-1. The animals were administered indomethacin (10 mg/kg, p.o.) and killed 24 h later. Lansoprazole (30-100 mg/kg, p.o.) and omeprazole (30-100 mg/kg, p.o.) were given 30 min before the administration of indomethacin, while tin-protoporphyrin IX (SnPP: 30 mg/kg, i.v.), an inhibitor of HO-1, was injected 10 min before indomethacin or lansoprazole. Indomethacin produced hemorrhagic lesions in the small intestine, accompanied with an increase of mucosal invasion of enterobacteria, inducible nitric oxide synthase (iNOS) expression, and myeloperoxidase (MPO) activity in the mucosa. Pretreatment with lansoprazole dose- dependently reduced the severity of the indomethacin-induced intestinal lesions, with suppression of the increased MPO activity, while omeprazole had no effect. Pretreatment with SnPP significantly exacerbated these intestinal lesions and almost totally abolished the protective effect of lansoprazole. The up-regulation of iNOS mRNA expression following indomethacin was suppressed by lansoprazole in a SnPP-inhibitable manner, although the enhanced enterobacterial invasion remained unaffected. The amount of HO-1 protein in the intestinal mucosa was significantly increased by lansoprazole but not by omeprazole. Prior administration of carbon monoxide (CO)-releasing molecule-2 (CORM-2; 10 mg/kg, i.p.) significantly reduced the severity of these lesions and the enhancement of mucosal iNOS mRNA expression induced in the small intestine by indomethacin. These results suggest that lansoprazole prevents indomethacin-induced small intestinal ulceration, and this effect is associated with inhibition of iNOS expression, through up-regulation of HO-1/CO production in the mucosa.

4

Virulence factor genotypes of Helicobacter pylori affect cure rates of eradication therapy

67%

Sugimoto M., Yamaoka Y.

Archivum Immunologiae et Therapiae Experimentalis

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2009

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tom 57

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nr 1

45-56

5

Evidence-based therapy according to the guideline for gastric ulcers is cost-effective in Japan

67%

Taniyama K., Shimbo T., Iwase H., Tanaka S., Watanabe N., Uemura N.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 6

6

The clinical aspects of Helicobacter heilmannii infection in children with dyspeptic symptoms

59%

Iwanczak B., Biernat M., Iwanczak F., Grabinska J., Matusiewicz K., Gosciniak G.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 2

7

Leki chroniące układ pokarmowy - co musimy wiedzieć

59%

Stilwell N.

Weterynaria po Dyplomie

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2019

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tom 20

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nr 4

8

Kilka słów o lekach hamujących wydzielanie soku żołądkowego u psów i kotów

43%

Volcarcel M.

Weterynaria po Dyplomie

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2017

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tom 18

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nr 1

Ograniczanie wyników

Relamorelin and other ghrelin receptor agonists - future options for gastroparesis, functional dyspepsia and PPI-resistant non-erosive reflux disease

Role of proton pump inhibitors in preventing hypergastrinemia-associated carcinogenesis and in antagonizing the trophic effect of gastrin

Prevention by lansoprazole, a proton pump inhibitor, of indomethacin-induced small intestinal ulceration in rats through induction of heme oxygenase-1

Virulence factor genotypes of Helicobacter pylori affect cure rates of eradication therapy

Evidence-based therapy according to the guideline for gastric ulcers is cost-effective in Japan

The clinical aspects of Helicobacter heilmannii infection in children with dyspeptic symptoms

Leki chroniące układ pokarmowy - co musimy wiedzieć

Kilka słów o lekach hamujących wydzielanie soku żołądkowego u psów i kotów