Wyniki wyszukiwania

1

Implications of kinase similarity in drug discovery

100%

Vieth M., Sutherland J.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.2

2

Features and potentials ATP-site directed CK2 inhibitors

100%

Pinna L. A.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.2

3

Caged regulators of signaling pathways

100%

Lawrence D. S., Wood J., Curley K.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

4

Searching for inhibitors of CDPK as potential drugs against parasites?

100%

Klimecka M., Szczegielniak J., Koper L., Koslinski M., Muszynska G.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.2

5

Protein kinase inhibitors - potential chemotherapeutic agents

100%

Shugar D.

Acta Biochimica Polonica

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1995

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tom 42

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nr 4

Protein kinase inhibitors, widely exploited for elucidation of the biological functions of kinases, have more recently come under active consideration as potential chemotherapeutic agents for tumour and other diseases. A brief overview is presented of diverse approaches to the design and development of selective protein kinase inhibitors, and related problems such as donor and acceptor specificities, stereochemical aspects, emerging relationships between protein, sugar and nucleoside kinases. In particular, and contrary to popular belief that ATP-competitive inhibifcrs cannot be selective because of the close homology of the ATP catalytic sites, numerous examples are presented of such inhibitors which are both potent and selective for a given kinase or class of kinases. Some of these are undergoing preclinical trials. Attention is also directed to the role of cellular and viral protein kinases in the ljfe cycle of viruses, and the potential of these enzymes, especially those encoded by, and essential for replication of, a given virus as targets for antiviral chemotherapy.

6

The physical nature of cAMP-dependent protein kinase catalytic activity: AB initio differential transition state stabilization analysis of the key active site residues

100%

Szarek P., Dyguda E., Sokalski W. A., Cheng Y., Zhang Y., McCammon J. A.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.2

7

Protein kinase inhibition of CDK2 by staurosporine

100%

Lawrie A. M., Noble M. E. M., Tunnah P., Brown N. R., Johnson L. N., Endicott J. A.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

8

The 45 kDa and 27 kDa yeast's protein kinases are notimmunologically related

100%

Szyszka R., Tchorzewski M., Dukowski P., Winiarczyk S., Gasior E.

Acta Biochimica Polonica

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1992

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tom 39

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nr 2

Two yeast casein kinase type-I sp«cies of 45 kDa and 27 kDa (CK1) were purified to apparent homogeneity and used for investigation of their immunological affinity. Antiscra against the two kinases were isolated; the antibody agaiast the 45 kDa kinase did not react with the 27 kDa enzyme. The 27 kDa casein kinase was recognized only by its own antibody. The obtained data strongly suggest that the low molecular mass CK-1 is not a proteolytic product of the 45 kDa kinase species.

9

Improving the efficiency of halogenated benzimidazole inhibitors of protein kinase CK2

100%

Meggio F., Pagano M. A., Andrzejewska M., Cesaro L., Kazimierczuk Z., Pinna L. A.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2A

10

cAMP-dependent protein kinase: structural basis for function, regulation, and subcellular localization

100%

Taylor S. S., Narayana N., Huang L., Banky P., Wang L., Cheng X.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

11

SCC DFT-TB energy calculations of the phosphoryl transfer reaction in the PKA active site

100%

Rakowski F., Grochowski P., Lesyng B.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2A

12

Controlling substrate specificity in protein kinases through chemical clamping

100%

Adams J. A.

Cellular and Molecular Biology Letters

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2005

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tom 10

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nr Suppl.2

13

Phosphorylation of A-proteins by protein kinases bound to yeast ribosomes

100%

Cytrynska M., Jakubowicz T., Gasior E.

Acta Biochimica Polonica

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1994

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tom 41

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nr 2

14

The feature of a general pharmacophore model for ATP-competing protein kinase inhibitors: the prospects for selective inhibitor design

100%

Cockcroft X., Howe T., Menear K.

Cellular and Molecular Biology Letters

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1998

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tom 03

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nr 3

15

Inhibition Hsp90 as a special way to inhibit protein kinases

100%

Csermely P., Soti C.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2A

16

Theoretical studies on sugar and protein kinases: structural and mutational variability

100%

Kuska J., Leluk J.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2A

17

Protein kinase inhibitors arrested the in-vitro growth of Theileria equi

88%

Yadav J., Goel P., Mandal K. D., Yadav R., Kumar N., Kumar R., Tripathi B. N., Kumar S.

Acta Parasitologica

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2020

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tom 65

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nr 3

18

Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor delta (GW501516) and 5-aminoimidazole- 4-carboxamide ribonucleotide (AICAR)

88%

Pokrywka A., Cholbinski P., Kaliszewski P., Kowalczyk K., Konczak D., Zembron-Lacny A.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 4

19

The involvement of adenylyl cyclase and protein kinase A in the mechanism of opioid peptide action in porcine theca interna cells

88%

Kaminski T., Siawrys G., Bogacka I., Okrasa S., Przala J.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

20

Substrate and inhibitor recognition of protein kinases: what in known about the catalytic subunit of phosphorylase kinase?

88%

Graves D. J., Bartleson C., Biorn A., Pete M.

Cellular and Molecular Biology Letters

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1998

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tom 03

|

nr 3

Ograniczanie wyników

Implications of kinase similarity in drug discovery

Features and potentials ATP-site directed CK2 inhibitors

Caged regulators of signaling pathways

Searching for inhibitors of CDPK as potential drugs against parasites?

Protein kinase inhibitors - potential chemotherapeutic agents

The physical nature of cAMP-dependent protein kinase catalytic activity: AB initio differential transition state stabilization analysis of the key active site residues