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High level expression of STAG1-PMEPA1 in an androgen-independent prostate cancer PC3 subclone

100%

Hirokawa Y. S., Takagi A., Uchida K., Kozuka Y., Yoneda M., Watanabe M., Shiraishi T.

Cellular and Molecular Biology Letters

2007

tom 12

nr 3

In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.

Prostate specific antigen levels after acute myocardial infarction

80%

Acikgoz S., Can M., Dogan S. M., Mungam G., Aydin M., Kelek S., Sumbuloglu V.

Acta Biochimica Polonica

2011

tom 58

nr 4

Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of prostatic tissue. In some case reports, changes in PSA levels after acute myocardial infarction (AMI) have been reported. In this study we evaluated variations in PSA levels post-AMI. Twenty-six male patients who had PSA levels within reference limits were included in the study. The diagnosis of AMI was confirmed by clinical findings, ECG (electrocardiogram) and cardiac marker studies. Serum total PSA (tPSA) and free PSA (fPSA) levels were measured at days 0 (day of admission), 1, 2 and 3 after AMI. PSA/albumin ratio was also calculated in order to evaluate the effect of dilution. A statistical analysis of the results of all patients revealed significant decrease in tPSA levels and tPSA/Albumin ratio at day 2 when compared to days 0 and 3, which showed a similar pattern. Changes of fPSA and fPSA/ Albumin ratio according to days were not found significant. In only four patients we found increased levels of tPSA and increased fPSA levels in three of them. These patients displayed severe problems such as renal failure, cardiac failure, ventricular aneurysm and cerebral ischemia due to cardiac arrest. The lower tPSA levels on day 2 suggest that tPSA can be eliminated rapidly from the circulation on days 1 and 2, probably through the formation of complexes of tPSA with acute phase proteins.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Cellular and Molecular Biology Letters

1 Acikgoz S.

1 Aydin M.

1 Can M.

1 Dogan S. M.

1 Hirokawa Y. S.

1 Kelek S.

1 Kozuka Y.

1 Mungam G.

1 Shiraishi T.

1 Sumbuloglu V.

1 Takagi A.

1 Uchida K.

1 Watanabe M.

1 Yoneda M.

1 2011

1 2007

Wyniki wyszukiwania

High level expression of STAG1-PMEPA1 in an androgen-independent prostate cancer PC3 subclone

Prostate specific antigen levels after acute myocardial infarction