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Isophosphoramide mustard analogues as prodrugs for anticancer gene-directed enzyme-prodrug therapy [GDEPT]

100%

Misiura K., Szymanowicz D., Kusnierczyk H., Wietrzyk J., Opolski A.

Acta Biochimica Polonica

2002

tom 49

nr 1

Two types of prodrugs, benzyl analogues of isophosphoramide mustard (iPAM), activated by cytochrome P450, and acylthioethyl analogues, activated by esterases, were designed. In contrast to iPAM that hydrolyse rapidly, the examined compounds are stable in phosphate-buffered saline and Tris buffer. Benzyl analogues of iPAM are poor substrates for cytochrome P450, are not cytotoxic and posses no antitumour activity. Acylthioethyl analogues of iPAM are good substrates for pig liver esterase, are cytotoxic and exert antitumour activity against L1210 leukaemia in mice. The observed correlation for iPAM analogues between their susceptibility to hydrolysis and cytotoxicity and antitumour activity suggests possible application of these compounds as the prodrugs in gene-directed enzyme-prodrug therapy.

Exploring novel colon-targeting antihistaminic prodrug for colitis

84%

Dhaneshwar S., Gautam H.

Journal of Physiology and Pharmacology

2012

tom 63

nr 4

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Journal of Physiology and Pharmacology

1 Dhaneshwar S.

1 Gautam H.

1 Kusnierczyk H.

1 Misiura K.

1 Opolski A.

1 Szymanowicz D.

1 Wietrzyk J.

1 2012

1 2002

Wyniki wyszukiwania

Isophosphoramide mustard analogues as prodrugs for anticancer gene-directed enzyme-prodrug therapy [GDEPT]

Exploring novel colon-targeting antihistaminic prodrug for colitis