Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 15

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  prednisolone
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Steroid hormone (prednisolone) influence on the unicellular Tetrahymena (an electron microscopic study)

100%
Csaba G., Fulop A. K.
Acta Protozoologica
|
1987
|
tom 26
|
nr 3
2
Content available remote

Relation of adrenergic receptors, which have roles in gastroprotective and anti-inflammatory effect of adrenal gland hormones, with cyclooxygenase enzyme levels in rats

84%
Suleyman H., Dursun H., Bilici M., Cadirci E., Halici Z., Gulaboglu M., Albayrak F.
Journal of Physiology and Pharmacology
|
2009
|
tom 60
|
nr 4
129-134
Background and Aims: COX-2 enzyme inhibition is responsible for the anti-inflammatory effects of NSAIDs, COX-1 for their effects upon the gastrointestinal system (GIS), along with other side effects. We investigated the relationship between COX levels and those adrenergic receptors known to play a role in gastroprotection and anti-inflammatory activity. Method: The effects of adrenaline and prednisolone on gastric COX-1 and COX-2 levels in both intact and adrenalectomized rats treated with doxazosin, yohimbine, propranolol, and metoprolol were determined. Results: We found that adrenaline increases COX-1 levels in the gastric tissue of both intact and adrenalectomized rats by stimulating -2 receptors. Adrenaline decreases COX-2 levels by stimulating ß-2 adrenergic receptors. Prednisolone inhibits both COX-1 and COX-2 in the gastric tissue of intact rats. In adrenalectomized rats, prednisolone increases gastric COX-1 by stimulating -2 receptors, and decreases COX-2 levels by stimulating ß-2 receptors. Conclusion: Prednisolone cannot bind to a adrenergic receptors in the presence of adrenaline (intact rats) but, in its absence (adrenalectomy), binds to -2 receptors, and stimulates them more effectively than adrenaline, suggesting a direct relationship between -2 adrenergic receptors and COX-1 levels, whereas ß-2 receptors are directly related to COX-2 levels.
3

Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats

84%
Folwarczna J., Nowinska B., Sliwinski L., Pytlik M., Cegiela U., Betka A.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 3
 Glucocorticoids and β2-adrenergic receptor agonists are the most commonly used drugs in the treatment of asthma. Both therapies are potentially dangerous to the skeletal system. The aim of the present study was to investigate the effects of fenoterol, a β2-receptor agonist, on the development of bone changes induced by glucocorticoid (prednisolone) administration in mature male rats. The experiments were carried out on 24-week-old male Wistar rats. The effects of prednisolone 21-hemisuccinate sodium salt (7 mg/kg s.c. daily) or/and fenoterol hydrobromide (1.4 mg/kg i.p. daily), administered for 4 weeks, on the skeletal system were studied. Bone turnover markers, geometric parameters, mass, mass of bone mineral in the tibia, femur and L-4 vertebra, bone histomorphometric parameters and mechanical properties of tibial metaphysis, femoral diaphysis and femoral neck were determined. Both prednisolone and fenoterol had damaging effects on the skeletal system of mature male rats. However, concurrent administration of fenoterol and prednisolone did not result in the intensification of the deleterious skeletal effect of either drug administered separately.
4
Content available remote

The role of prednisolone and epinephrine on gastric tissue and erythrocyte antioxidant status in adrenalectomized rats

84%
Yildirim A., Sahin Y. N., Suleyman H., Yilmaz A., Yildirim S.
Journal of Physiology and Pharmacology
|
2007
|
tom 58
|
nr 1
It has been believed that overproduction of free radicals and/or deficiency of antioxidant systems, and stress hormones may play a role in etiopathogenesis of many diseases, including gastric ulcer. This study evaluated whether there was an effect of adrenalectomy on lipid peroxidation [malondialdehyde (MDA)] and antioxidant [superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione (GSH) levels] systems in gastric tissue and erythrocyte in rats. As well, the impacts of administration of prednisolone and epinephrine on these systems in adrenalectomized rats were investigated. Thirty-three rats were randomly grouped as sham-operated (group I), adrenalectomized (group II), adrenalectomized + prednisolone (group III) and adrenalectomized + epinephrine (group IV). After experimental procedures, blood and gastric tissues samples were taken from each animal in all groups. Colorimetric assays were employed to determine gastric tissue and erythrocyte levels of MDA and GSH, and SOD and GPX activities. Adrenalectomy in group II rats caused a marked decrease of SOD and GPX activities and MDA levels, and an increase of GSH levels in gastric tissue and erythrocyte, when compared to sham-operated rats. However, especially epinephrine injection after adrenalectomy resulted in a significantly increase of measured antioxidant enzyme activities and GSH levels in both gastric tissue and erythrocyte. These results indicate that adrenalectomy appeared to alter the levels of antioxidants and lipid peroxidation product in gastric tissue and erythrocyte. Thus, the present study provides a physiological regulatory role of adrenal gland in the maintenance of oxidant/antioxidant balance in gastric tissue and erythrocyte.
5

Metabolitic activity of 11-deoxycorticosterone and prednisolone in the alga Chlorella vulgaris Beijerinck

84%
Czerpak R., Szamrej I. K.
Acta Societatis Botanicorum Poloniae
|
2000
|
tom 69
|
nr 1
6

The influence of suppression of adrenocortical function on progesterone and estrone sulphate levels in blood of late pregnant cows

84%
Zdunczyk S., Janowski T., Ras A.
Polish Journal of Veterinary Sciences
|
1998
|
tom 01
|
nr 1
Four cows were treated on day 260 of pregnancy with 300 mg prednisolone succinate i.m., and four other cows with saline solution. Blood samples were taken 4 times daily during a period of 5 days. The concentrations of cortisol progesterone and estrone sulphate in plasma were determined using radioimmunoassay. After V administration of prednisolone the level of Cortisol was depressed for 3 days and returned to initial values afterwards. The level of progesterone was lowered during this time, but the decrease was not statistically siginificant. The estrone sulphate level was not significantly altered by prednisolone administration. In the control cows receiving saline, the concentration of hormones remained nearly constant. There was no statistical difference in gestation length compared to the control group. The results obtained indicate that the suppression of adrenal cortex function in cows on day 260 of pregnancy had little or no effects on progesterone and estrone sulphate. Thus, it appeared that the adrenal contribution to the peripheral blood plasma level of progesterone is small and the synthesis of estrone sulphate by bovine placenta is probably independent of maternal adrenal precursors.
7

Effects of vitamin E and prednisolone on biochemical and haematological parameters in endotoxaemic New Zealand white rabbits

84%
Yazar E., Col R., Konyalioglu S., Birdane Y. O., Elmas M., Bas A. L.
Bulletin of the Veterinary Institute in Puławy
|
2004
|
tom 48
|
nr 2
8

Pharmacological and toxicological aspects of combination of beta-lactam and aminoglycoside antibiotic, prednisolone and procaine hydrochloride on the example of vetramycin

67%
Kania B. F., Kania K.
Polish Journal of Veterinary Sciences
|
2003
|
tom 06
|
nr 4
9

Comparative study of immunomodulatory agents to induce human T regulatory (Treg) cells: preferential Treg-stimulatory effect of prednisolone and rapamycin

67%
Janyst M., Kaleta B., Janyst K., Zagozdzon R., Kozlowska E., Lasek W.
Archivum Immunologiae et Therapiae Experimentalis
|
2020
|
tom 68
|
nr 4
10

The effect of beta-estradiol and corticosteroids on chlorophylls and carotenoids content in Wolffia arrhiza [L.] Wimm. [Lemnaceae] growing in municipal Bialystok tap water

67%
Czerpak R., Szamrej I. K.
Polish Journal of Environmental Studies
|
2003
|
tom 12
|
nr 6
It is well known that many steroid compounds, mainly from large stock-raising farms, more frequently end up in rural or communal sewage systems. It is also known that the duckweed family (Lemnaceae), especially Wolffia arrhiza, is more and more commonly used in the biotechnology of purifying the above-mentioned sew­age systems due to its heterotrophic and detoxication ability, as well as its ease of adoption to unfavorable environmental conditions. Therefore, our research analyzes the influence of beta-estradiol and chemically and functionally diversified corticosteroids: cortisone, cortisole (glucocorticoids), "-deoxycorticosterone (miner- alocorticoids) and prednisolone (chemical derivative of hydrocortisone) on chlorophylls and carotenoids content in photoautotrophic Wolffia arrhiza (Lemnaceae), growing in municipal Białystok tap water (rich in minerals but poor in organic components). From the applied steroid hormones in optimal concentration of 10-6M p-es- tradiol caused the strongest stimulatory effect on photosynthetic pigments, a little less strong - cortisone, slight stimulative - cortisole, and weak "-deoxycorticosterone. Prednisolone showed a weak inhibitory influence on all types of chlorophylls and carotenoids in comparison with the control culture without exogenous hormones. Applied steroid hormones had a weak stimulative influence over chlorophylls a and b in Wolffia; the strongest was p-estradiol between the 5th and the 10th day of cultivation, in the range of 116.5-121.3% in comparison to the control value (100%). The researched steroids had a much stronger influence on carotenoid content, especially p-carotene, alloxanthin (oxygen - poor xanthophylls) and violaxanthin (oxygen - rich xanthophylls). Under the influence of beta-estradiol the amount of p-carotene rose by the maximum 160.6%, alloxanthin by 187.9% and violaxanthin by 154.3% in comparison to the control. Our research results demonstrated that p-estradiol and - from applied corticosteroids - cortisone and hydrocorticosterone, had more stimulatory influence on carotenoid content in Wolffia arrhiza, but less stimulatory effect on unicellular Chlorella vulgaris.
11

The effect of sex steroids and corticosteroids on the content of soluble proteins, nucleic acids and reducing sugars in Wolffia arrhiza [L.] Wimm. [Lemnaceae]

67%
Szamrej I. K., Czerpak R.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr 5
Research on the influence of sex steroids: ß-estradiol, testosterone and corticosteroids: cortisone, cortisole (glucocorticoids), 11-deoxycorticosterone (mineralocorticoid) and prednisolone (chemical derivative of hydrocortisone) on changes of soluble proteins, nucleic acids and reducing sugars as a content of Wolffia arrhiza ( Lemnaceae ) has been conducted. Wolffia has been cultivated in Bialystok’s municipal tap water (rich in mineral but poor in organic components) during a 20-day period, in the optimal concentration of 10-5 to 10-6 M. It has been ascertained that the maximal stimulation of nucleic acids (DNA & RNA) was caused by ß-estradiol in the range from 176-181%, testosterone 168-173%, cortisone 154-157%, 11-deoxycorticosterone 152-155%, cortisole 141-148% and prednisolone from 129-131%, in comparison to a 100% control. The soluble proteins content was stimulated the strongest by ß-estradiol - 181%, testosterone - 170%, cortisole - 141%, cortisone - 138%, prednisolone - 137%, and weaker by 11-deoxycorticosterone - 128%. Reducing sugars content was stimulated most intensely only on the 5th day of cultivation by cortisone in 165%, 11-deoxycorticosterone - 160-164%, cortisole in 157% and prednisolone in 149%, whereas ß-estradiol had a stimulatory influence of 133-138% and testosterone – 119-121% in comparison to 100% control during the whole period of 20 days of Wolffia arrhiza cultivation.
12

Thalidomide increases in vitro sensitivity of childhood acute lymphoblastic leukemia cells to prednisolone and cytarabine

67%
Czyzewski K., Zaborowska A., Styczynski J.
Archivum Immunologiae et Therapiae Experimentalis
|
2006
|
tom 54
|
nr 5
13
Content available remote

Indirect role of beta2-adrenergic receptors in the mechanism of anti-inflammatory action of NSAIDs

59%
Suleyman H., Halici Z., Cadirci E., Hacimuftuoglu A., Bilen H.
Journal of Physiology and Pharmacology
|
2008
|
tom 59
|
nr 4
661-672
In this study we investigated both intact and adrenalectomized rats to determine whether or not the anti-inflammatory effects of indomethacin, diclofenac sodium, ibuprofen, nimesulide, tenoxicam and aspirin (IDINTA) are related to adrenal gland hormones in carrageenan-induced inflammation model of rats. Also, we investigated the anti-inflammatory action mechanism of hormones (adrenalin, cortisol) which perform a role in the anti-inflammatory effect of IDINTA on the adrenergic receptors. The results show that IDINTA produces significant anti-inflammatory effects in intact rats (ID50: 9.82, 10.81, 95.21, 75.23, 8.21 and 61.84 mg/kg), but insignificant effects in adrenalectomized rats (ID50: 152.97, 188.17, 1275.0, 433.67, 188.16 and 1028.17 mg/kg). In addition, adrenalin and prednisolone caused anti-inflammatory effect rates of 78.3% and 95.7% respectively in adrenalectomized rats. The anti-inflammatory effects of adrenalin and prednisolone did not change when prazosin (1-receptor blocker), yohimbine (2-receptor blocker) and phenoxybenzamine (1- and 2- receptor blocker) were given to rat groups; however, in adrenalectomized rats administered with propranolol (a non-selective blocker of ß1 and ß2-receptors) the anti-inflammatory effect of adrenalin was lost, and that of prednisolone decreased to 36.2%. It was also found that metoprolol (a selective blocker of ß1-receptors) did not alter the anti-inflammatory effects of the drugs. As a result, it was shown that anti-inflammatory effects of IDINTA are related to adrenalin and cortisol (corticosterone in rats). It was also determined for the first time that adrenalin (totally) and prednisolone (partially) triggered anti-inflammatory effects via the ß2-receptors but not via the 1, 2 and ß1-receptors.
14

NANC transmission in intestines and its pharmacological modulation

59%
Bauer V.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 1
15

Idiopatyczne ropno-ziarniniakowe zapalenie skóry u psa - opis przypadku

51%
Pryszcz M., Likus M., Albu K.
Weterynaria w Praktyce
|
2020
|
tom 17
|
nr 03
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.