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Antiparasitic drug-design strategy as an interdisciplinary process

100%

Boczon K.

Wiadomości Parazytologiczne

1994

tom 40

nr 3

Molecular cloning and characterisation of phosphoglycerate kinase from Fasciola hepatica

61%

Jaros S., Wesolowska A., Jaros D., Zygner W., Wedrychowicz H.

Bulletin of the Veterinary Institute in Puławy

2011

tom 55

nr 3

This paper is focused on cloning and bioinformatical as well as immunological characterisation of the new vaccine antigen candidate against fasciolosis - Fasciola hepatica phosphoglycerate kinase (FhPGK). The antigen was cloned from the adult fluke by the use of RACE-PCR method. It was found that FhPGK is not a secretory and not a stage specific protein. It is present in all kinds of parasite tissue, particularly in fluke intestine and tegumental as well as subtegumental layers. FhPGK is involved in production of the first ATP molecule in the glycolytic pathway and can be used in vaccination trials in which the strategy is to block fluke's energy metabolism. This is the first, to date, phosphoglycerate kinase cloned from F. hepatica.

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Wiadomości Parazytologiczne

1 Boczon K.

1 Jaros D.

1 Jaros S.

1 Wedrychowicz H.

1 Wesolowska A.

1 Zygner W.

1 2011

1 1994

Wyniki wyszukiwania

Antiparasitic drug-design strategy as an interdisciplinary process

Molecular cloning and characterisation of phosphoglycerate kinase from Fasciola hepatica