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1

Elastase, alpha1-proteinase inhibitor, and interleukin-8 in children and young adults with end-stage kidney disease undergoing continuous ambulatory peritoneal dialysis

100%
Polanska B., Augustyniak D., Makulska I., Niemczuk M., Jankowski A., Zwolinska D.
Archivum Immunologiae et Therapiae Experimentalis
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2014
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tom 62
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nr 3
2

Peritoneal dialysis in dogs and cats

100%
Lew S., Kuleta Z., Pomianowski A.
Polish Journal of Veterinary Sciences
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2005
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tom 08
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nr 4
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

In vitro culture of human peritoneal mesothelium for investigation of mesothelial dysfunction during peritoneal dialysis

100%
Witowski J., Breborowicz A., Knapowski J., Oreopoulos D.
Journal of Physiology and Pharmacology
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1994
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tom 45
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nr 2
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

HI antibody kinetics in children with renal failure immunized with inactivated trivalent influenza vaccine

100%
Brydak L. B., Roszkowska-Blaim M., Leszczynska B., Rudnicka H.
Bulletin of the Veterinary Institute in Puławy
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1998
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tom 42
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nr 1
5
Content available remote

The activation of complement system in different types of renal replacement therapy

84%
Stepniewska J., Dolegowska B., Golebiewska E., Marchelek-Mysliwiec M., Domanski M., Ciechanowski K., Zair L.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 2
6

Serum soluble Klotho protein level is associated with residual diuresis in incident peritoneal dialysis patients

84%
Golembiewska E., Safranow K., Kabat-Koperska J., Myslak M., Ciechanowski K.
Acta Biochimica Polonica
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2013
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tom 60
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nr 2
 Aim: Active vitamin D (1,25-dihydroxyvitamin D3), PTH, fibroblast growth factor-23 (FGF-23) and Klotho protein are key regulators of phosphate metabolism. Hyperphosphatemia and increased FGF-23 level in patients with end-stage renal disease are associated with increased morbidity and mortality. The relationships among key regulators of phosphate metabolism are still being investigated. FGF-23, the humoral factor involved in phosphate metabolism, is strongly associated with serum phosphorus level. Klotho, a transmembrane protein expressed primarily in renal tubules, functions as an obligatory co-receptor for FGF-23. The soluble form of Klotho, produced by the shedding of the transmembrane protein, is detectable in body fluids. The purpose of the study was to assess if serum soluble alpha-Klotho level was related to phosphate metabolism parameters and residual renal function (RRF) in incident peritoneal dialysis (PD) patients. Methods: Thirty-five clinically stable patients 4 to 6 weeks after the onset of PD were included in the study. For each patient, clinical and laboratory data were reviewed. Serum phosphorus concentration, urinary and peritoneal phosphate clearance, serum FGF-23 and soluble Klotho protein concentrations were determined. Results: Serum soluble alpha-Klotho was strongly negatively correlated with 24-hour diuresis (Rs = -0.55, p = 0.004) and renal phosphate clearance (Rs = -0.40, p = 0.049), but not with RRF. Conclusions: Serum soluble Klotho protein concentration is inversely related to residual diuresis and renal phosphate clearance in incident PD patients.
7
Content available remote

Sulodexide modulates the dialysate effect on the peritoneal mesothelium

84%
Misian M., Baum E., Breborowicz A.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 6
8
Content available remote

L-2-oxothiazolidine-4-carboxylic acids slow down dialysate-induced senescence in human peritoneal mesothelial cells

84%
Sosinska-Zawierucha P., Mackowiak B., Begier-Krasinska B., Hoppe K., Breborowicz A.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 6
9

Vitamin K status in peritoneally dialyzed patients with chronic kidney disease

84%
Stankowiak-Kulpa H., Krzyzanowska P., Koziol L., Grzymislawski M., Wanic-Kossowska M., Moczko J., Walkowiak J.
Acta Biochimica Polonica
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2011
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tom 58
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nr 4
Abnormal vitamin K status was documented in patients with chronic kidney diseases (CKD), especially those undergoing hemodialysis. The data related to patients undergoing peritoneal dialysis (PD) are contradictory. Therefore, in the present study we aimed to evaluate vitamin K status in patients with CKD who are treated with continuous ambulatory PD. Twenty-eight patients entered into the study. Dialysis vintage ranged from 3 to 89 months. Vitamin K status was assessed in all subjects using undercarboxylated prothrombin measurement (PIVKA-II). In addition, total protein and albumin levels, total cholesterol, LDL cholesterol, triglyceride, calcium, urea and creatinine concentrations were determined. PIVKA-II concentrations were abnormal in 13 (46.4 %) subjects. BMI values, both total and LDL cholesterol concentrations were significantly higher in patients with than those without vitamin K deficiency. Moreover, PIVKA II levels correlated with BMI values (r = 0.441, p < 0.019), LDL cholesterol (r = 0.434, p < 0.021) and creatinine (r = 0.406, p < 0.032) concentrations. However, through the use of logistic regression analysis and multiple regression analysis, no clinical factor was documented to be the independent risk factor of vitamin K deficiency. In conclusion, vitamin K deficiency is a frequent condition in peritoneally dialyzed patients. Assessment of vitamin K status should become a standard procedure in this group of patients.
10

Post‑transplant alternative complement pathway activation infuences kidney allograft function

84%
Bartoszek D., Mazanowska O., Koscielska-Kasprzak K., Lepiesza A., Myszka M., Zabinska M., Krajewska M., Klinger M.
Archivum Immunologiae et Therapiae Experimentalis
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2019
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tom 67
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nr 3
11

MiR-30b is involved in methylglyoxal-induced epithelial-mesenchymal transition of peritoneal mesothelial cells in rats

84%
Liu H., Zhang N., Tian D.
Cellular and Molecular Biology Letters
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2014
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tom 19
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nr 2
Epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMC) is a major contributor to the pathogenesis of peritoneal fibrosis. EMT is at least in part caused by repeated exposure to glucose degradation products (GDPs), such as methylglyoxal (MGO). MiRNA contributes greatly to the EMT of PMCs. In this study, we tried to profile whether differences exist between the peritoneal membrane (PM) miRNA expression seen in control rats and that seen in rats injected intraperitoneally with MGO. We assessed whether miR-30b has a possible role in MGO-induced EMT of PMCs in rats. Comparative miRNA expression array and real-time PCR analyses were conducted for the control group at the start of the experiment and for the MGO group after 1 and 2 weeks. During the second week, the MGO rats were treated with: a chemically modified antisense RNA oligonucleotide (ASO) complementary to the mature miR-30b (ASO group); an miR-30b mismatch control sequence (MIS group); or a citrate buffer (EMT group). Bioinformatic analyses indicated that the 3′ untranslated region (3′-UTR) of bone morphogenetic protein 7 (BMP7) mRNA did contain a putative binding site for miR-30b. We also tried to investigate whether miR-30b targeted BMP7 in vitro by transfection. Of the upregulated miRNAs, miR-30b expression demonstrated the greatest increase. The administration of miR-30b ASO for two weeks significantly reduced α-SMA excretion and upregulated E-cadherin and BMP-7 expression. Our in vitro study showed that miR-30b directly targeted and inhibited BMP7 by binding to its 3’-UTR. Our results revealed that miR-30b is involved in MGO-induced EMT of PMCs in rats.
12
Content available remote

N-acetylcysteine modulates effect of the iron isomaltoside on peritoneal mesothelial cells

84%
Misian M., Baum E., Breborowicz A.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 3
13

Changes in the phagocytic cells in children treated with continuous ambulatory peritoneal dialysis

84%
Wasik M., Blaim M., Kolewska D., Janota-Krawczyk E., Tomaszewska-Panczyk M., Sieniawska M.
Archivum Immunologiae et Therapiae Experimentalis
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1997
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tom 45
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nr 2-3
14
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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In vitro effect of glutathione precursors on cytotoxicity of amino acids to human mesothelial cells

84%
Grzybowski A. E.
Journal of Physiology and Pharmacology
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1999
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tom 50
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nr 3
15
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Effect of vitamin E on peroxidation and permeability of the peritoneum

67%
Wieczorowska-Tobis K., Breborowicz A., Witowski J., Martis L., Oreopoulos D. G.
Journal of Physiology and Pharmacology
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1996
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tom 47
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nr 3
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