Wyniki wyszukiwania

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Influence of vagal nerve stimulation on food intake and body weight - results of experimental studies

100%

Sobocki J., Krolczyk G., Herman R. M., Matyja A., Thor P. J.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 6

27-33

The paper reviews recent advances in vagal nerve stimulation for the control of food intake and body weight. The vagal nerves are the predominant pathway in the "brain-gut axis" responsible for short term regulation of food intake. Stimulation of afferent vagal traffic attenuates food intake by vagal projections to nucleus tractus solitarius, arcuate nucleus and its convergence’s to thalamic center of satiety. A few studies have been published in this field so far. All of them are consistent and show significant decrease in body mass during vagal stimulation. Due to promising results of experimental studies, clinical trials are expected in the near future.

2

Alteration of peptidergic gut-brain signaling under conditions of obesity

100%

Kuhne S. G., Stengel A.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 5

3

The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet

80%

Wierucka-Rybak M., Wolak M., Bojanowska E.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 4

4

Peptidyl hormones of endocrine cells origin in the gut - their discovery and physiological relevance

80%

Ceranowicz P., Warzecha Z., Dembinski A.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 1

5

The effect of pregnane x receptor agonists on postprandial incretin hormone secretion in rats and humans

80%

Hukkanen J., Rysa J., Makela K. A., Herzig K.-H., Hakkola J., Savolainen M. J.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 6

6

Brain-gut axis in pancreatic secretion and appetite control

80%

Konturek S. J., Pepera J., Zabielski K., Konturek P. C., Pawlik T., Szlachcic A., Hahn E. G.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 3

The stimulation of exocrine pancreatic secretion that has been attributed by Pavlov exclusively to various reflexes (nervism), was then found that it depend also on numerous enterohormones, especially cholecystokinin (CCK) and secretin, released by duodeno-jejunal mucosa and originally believed to act via an endocrine pathway. Recently, CCK and other enterohormones were found to stimulate the pancreas by excitation of sensory nerves and triggering vago-vagal and entero-pancreatic reflexes. Numerous neurotransmitters and neuropeptides released by enteric nervous system (ENS) of gut and pancreas have been also implicated in the regulation of exocrine pancreas. This article was designed to review the contribution of vagal nerves and entero-hormones, especially CCK and other enterohormones, involved in the control of appetitive behavior such as leptin and ghrelin and pancreatic polypeptide family (peptide YY and neuropeptide Y). Basal secretion shows periodic fluctuations with peals controlled by ENS and by motilin and Ach. Plasma ghrelin, that is considered as hunger hormone, increases under basal conditions, while plasma leptin falls to the lowest level. Postprandial pancreatic secretion, classically divided into cephalic, gastric and intestinal phases, involves predominantly CCK, which under physiological conditions acts almost entirely by activation of vago-vagal reflexes to stimulate the exocrine pancreas, being accompanied by the fall in plasma ghrelin and increase of plasma leptin, reflecting feeding behavior. We conclude that the major role in postprandial pancreatic secretion is played by vagus and gastrin in cephalic and gastric phases and by vagus in conjunction with CCK and secretin in intestinal phase. PP, PYY somatostatin, leptin and ghrelin that affect food intake appear to participate in the feedback control of postprandial pancreatic secretion via hypothalamic centers.

Ograniczanie wyników

Influence of vagal nerve stimulation on food intake and body weight - results of experimental studies

Alteration of peptidergic gut-brain signaling under conditions of obesity

The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet

Peptidyl hormones of endocrine cells origin in the gut - their discovery and physiological relevance

The effect of pregnane x receptor agonists on postprandial incretin hormone secretion in rats and humans

Brain-gut axis in pancreatic secretion and appetite control