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The influence of repeated systemic penicillin injections at subconvulsive doses on spontaneous Spike-Wave Discharges in the rat

100%

Stankiewicz J., Gralewicz S.

Acta Neurobiologiae Experimentalis

1996

tom 56

nr 3

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Evaluation of antiepileptic activity of methanolic leaves extract of Tragia involucrata Linn. in mice

80%

Varma G. G., Mathai B. K., Das K., Gowda G., Rammohan S., Einstein J. W.

International Letters of Natural Sciences

2014

tom 12

nr 2

The present investigation was aimed to study an antiepileptic activity of methanolic extract of Tragia involucrata Linn in mice. In vivo screening models like maximal electroshock-induced convulsion (MES), pentylenetetrazole (PTZ) and picrotoxin (PTX) induced models are used to evaluate the antiepileptic effects of the extracts. The biochemical estimation was done by measuring the lipid peroxidation and reduced glutathione (GSH). In the MES induced convulsion, methanolic extract of Tragia involucrata (METI) at high dose (800 mg/kg body weight), showed high significant inhibition on tonic hind limb extension (THLE, 6.83 ±0.30***) and decrease in duration of stupor period (108.7 ±6.53***). In PTZ and PTX induced model METI (400 mg/kg and 800 mg/kg) showed significant delay on the onset of convulsions, decreased duration of convulsion and reduced mortality significantly. It also showed significant decrease in brain MDA level in lipid peroxidation profile, and increase in the brain glutathione levels in mice against PTZ induced convulsion. The results confirmed that Tragia involucrata Linn possesses dose dependent antiepileptic activity.

Seizures-evoked activation of transcription factors

80%

Kaminska B., Lukasiuk K., Kaczmarek L.

Acta Neurobiologiae Experimentalis

1994

tom 54

nr 2

Ograniczanie wyników

2 Acta Neurobiologiae Experimentalis

1 International Letters of Natural Sciences

1 Das K.

1 Einstein J. W.

1 Gowda G.

1 Gralewicz S.

1 Kaczmarek L.

1 Kaminska B.

1 Lukasiuk K.

1 Mathai B. K.

1 Rammohan S.

1 Stankiewicz J.

1 Varma G. G.

1 2014

1 1996

1 1994

Wyniki wyszukiwania

The influence of repeated systemic penicillin injections at subconvulsive doses on spontaneous Spike-Wave Discharges in the rat

Evaluation of antiepileptic activity of methanolic leaves extract of Tragia involucrata Linn. in mice

Seizures-evoked activation of transcription factors