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The role of metal ions in biological oxidation - the past and the present

100%

Kleczkowski M., Garncarz M.

Polish Journal of Veterinary Sciences

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2012

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tom 15

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nr 1

Two theories, one based on the metabolism of inorganic substances, the other on metabolism of organic substances, have played an important role in the explanation of the origin of life. They demonstrate that the original environment of life on Earth was seawater containing micronutrients with structural, metabolic and catalytic activity. It is assumed that the first primitive organisms lived around 3.8 billion years ago and it was also then that the first catalytic reaction involving metal ions occurred. Biological oxidation leading to oxidative stress and cell damage in animals represents one of these types of reactions which are responsible for many animal diseases. The role of prooxidative and antioxidative actions of transition metal ions as well as their neuropathological consequences have therefore been the topic for many research projects. There is hope that metal chelates and antioxidants might prove to be a modern mode of therapy for i.e. neurogenerative diseases. The aim of this review is to show the evolution of scientific knowledge on metal ions, their biological oxidation, and an overview of their role in physiology and in pathological processes.

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The activation and inactivation of lysosomal and extralysosomal compartments - a simple general model

100%

Turski W. A., Zaslonka J., Szram S., Mussur M.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

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Identification of the DNA binding element of the human ZNF300 protein

84%

Qiu H., Xue L., Gao L., Shao H., Wang D., Guo M., Li W.

Cellular and Molecular Biology Letters

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2008

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tom 13

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nr 3

391-403

The human ZNF300 gene is a member of the KRAB/C2H2 zinc finger gene family, the members of which are known to be involved in various developmental and pathological processes. Here, we show that the ZNF300 gene encodes a 68-kDa nuclear protein that binds DNA in a sequence-specific manner. The ZNF300 DNA binding site, C(t/a)GGGGG(c/g)G, was defined via a random oligonucleotide selection assay, and the DNA binding site was further confirmed by electrophoretic mobility shift assays. A potential ZNF300 binding site was found in the promoter region of the human IL-2Rβ gene. The results of electrophoretic mobility shift assays indicated that ZNF300 bound to the ZNF300 binding site in the IL-2Rβ promoter in vitro. Transient co-transfection assays showed that ZNF300 could activate the IL-2Rβ promoter, and that the activation was abrogated by the mutation of residues in the ZNF300 binding site. Identifying the DNA binding site and characterizing the transcriptional regulation property of ZNF300 would provide critical insights into its potential as a transcriptional regulator.

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The involvement of oxidative stress in determining the severity and progress of pathological processes in dystrophin-deficient muscles

84%

Niebroj-Dobosz I., Hausmanowa-Petrusewicz I.

Acta Biochimica Polonica

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2005

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tom 52

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nr 2

In both forms of muscular dystrophy, the severe Duchenne’s muscular dystrophy (DMD) with lifespan shortened to about 20 years and the milder Becker dystrophy (BDM) with normal lifespan, the gene defect is located at chromosome locus Xp21. The location is the same in the experimental model of DMD in the mdx mice. As the result of the gene defect a protein called dystrophin is either not synthesized, or is produced in traces. Although the structure of this protein is rather well established there are still many controversies about the dystrophin function. The most accepted suggestion supposes that it stabilizes sarcolemma in the course of the contraction-relaxation cycle. Solving the problem of dystrophin function is a prerequisite for introduction of an effective therapy. Among the different factors which might be responsible for the appearance and progress of dystrophic changes in muscles there is an excessive action of oxidative stress. In this review data indicating the influence of oxidative stress on the severity of the pathologic processes in dystrophy are discussed. Several pieces of data indicating the action of oxidative damage to different macromolecules in DMD/BDM are presented. Special attention is devoted to the degree of oxidative damage to muscle proteins, the activity of neuronal nitric oxide synthase (nNOS) and their involvement in defining the severity of the dystrophic processes. It is indicated that the severity of the morbid process is related to the degree of oxidative damage to muscle proteins and the decrease of the nNOS activity in muscles. Estimation of the degree of the destructive action of oxidative stress in muscular dystrophy may be a useful marker facilitating introduction of an effective antioxidant therapy and regulation of nNOS activity.

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Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation

84%

Pryczynicz A., Guzinska-Ustymowicz K., Dymicka-Piekarska V., Czyzewska J., Kemona A.

Folia Histochemica et Cytobiologica

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2007

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tom 45

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nr 1

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Infection, invasion and intoxication in fish organism

84%

Jara Z.

Wiadomości Parazytologiczne

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1994

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tom 40

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nr 3

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Paracetamol (acetaminophen) decreases hydrogen sulfide tissue concentration in brain but increases it in the heart, liver and kidney in mice

67%

Wilinski B., Wilinski J., Somogyi E., Goralska M., Piotrowska J.

Folia Biologica

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2011

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tom 59

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nr 1-2

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Bivalent cations involvement in opiates addiction

67%

Nechifor M.

Żywienie Człowieka i Metabolizm

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2007

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tom 34

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nr 1-2

Bivalent cations from brain influence many normal and pathological processes. Pharmacodependences are among the pathological processes were some bivalent cations are involved. The effects of these cations on opiate addiction are different. Generally, the links between intra or extra cellular concentrations of bivalent cations have modulatory effect on intensity of opiate addiction and symptoms of withdrawal syndrome. Calcium enhances intensity of opiate addiction. Our data show that magnesium diminished almost all symptoms from withdrawal in morphine-induced addiction. Manganese and zinc administrated during emerging morphine addiction in rat decreases significantly and specifically some symptoms during withdrawal syndrome. Copper doesn't influence significantly either intensity of addiction or symptoms from withdrawal syndrome if it is administered during expression faze. Alimentary intake or therapy with these cations may change intensity of opiate addiction.

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Sensitivity of human cutaneous mast cells to anaphylactic and nonimmunological stimuli

67%

Brzezinska-Blaszczyk E., Zalewska A.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

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nr 1

Ograniczanie wyników

The role of metal ions in biological oxidation - the past and the present

The activation and inactivation of lysosomal and extralysosomal compartments - a simple general model

Identification of the DNA binding element of the human ZNF300 protein

The involvement of oxidative stress in determining the severity and progress of pathological processes in dystrophin-deficient muscles

Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation

Infection, invasion and intoxication in fish organism

Paracetamol (acetaminophen) decreases hydrogen sulfide tissue concentration in brain but increases it in the heart, liver and kidney in mice

Bivalent cations involvement in opiates addiction

Sensitivity of human cutaneous mast cells to anaphylactic and nonimmunological stimuli