Wyniki wyszukiwania - AGRO

1

Study of the arterial blood supply of the pancreas harvested for transplantation

100%

Fiedor P., Rezulski J., Wierzbicki Z., Danielewicz R., Michalak G., Walaszewski J., Nowak M., Rowinski W.

Folia Morphologica

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1989

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tom 48

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nr 1-4

2

Changes in pancreatic lysosomal enzymes activity as the potential factors leading to diabetic enteropathy

100%

Maciejewski R., Burski K., Baj J., Madej B., Burdan F., Dabrowski A., Brakowiecki F.

Journal of Physiology and Pharmacology

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2001

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tom 52

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nr 4,2

The aim of this study was to establish and quantify changes in the activities of total, free and bound fractions of pancreatic lipase, galactoso-6-sulphatase, ß-D-galactosidase and N-acetyl-ß-D-glucosaminidase in the course of alloxan-induced diabetes mellitus. Rabbits were divided into a control group and groups injected with alloxan on the 21 st , 42 nd , 90 th and the 180 th day, after which blood samples were taken and the rabbits sacrificed by decapitation. The pancreas was removed and the glucose level measured. Enzyme activities were assayed by spectrophotometric methods. The total activities of N-acetyl-ß-D-glucosaminidase and ß-D-galactosidase were the lowest on day 42 of the test, and the total activity of lipase was the highest at this point of time, as compared to the other periods of the study. We conclude that in the course of alloxan-induce diabetes activities of pancreatic lipase and sulphatase were increasing following the levels of glucose, whilst activities of ß-D-galactosidase and N-acetyl-ß-D-glucosaminidase were declining, being inversely correlated to the level of glucose and activities of the first two mentioned enzymes. Above alterations in activity of lysosomal pancreatic enzymes of alloxan induced diabetic rabbits may be responsible for some aspects of previously reported diabetic enteropathy and chronic complications, or may provide a mechanism for the pancreatic beta-cells to moderate their insulin content.

3

Adrenergic and cholinergic innervation of the chicken pancreas

88%

Ulas M., Penkowski A., Lakomy M.

Folia Morphologica

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2003

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tom 62

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nr 3

243-246

The distribution, as well as the morphological characteristics of adrenergic and cholinergic nerve fibres was studied in the pancreas of the hen and the cock. The presence of numerous adrenergic and moderately numerous cholinergic structures was revealed in the organ. They were seen as nerve fibre bundles or single nerve fibres located in the vicinity of blood vessels and exocrine ducts, as well as the cells of the exocrine and endocrine pancreas. Single TH- and ChAT-positive nerve cell bodies were also found in the organ under study.

4

Morphometry of the pancreas in human foetuses

88%

Krakowiak-Sarnowska E., Flisinski P., Szpinda M., Sarnowski J., Lisewski P., Flisinski M.

Folia Morphologica

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2005

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tom 64

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nr 1

29-32

With the use of conventional anatomical dissection, radiography, digital and statistical analysis, morphometry and skeletopy of the pancreas was carried out in 60 human foetuses of both sexes (28 female, 32 male) between the 17th and 40th week of intrauterine life. The material was fixed in a 10% formalin solution. The age of the foetuses was determined by crown-rump (CR) lenght measurement on the basis of the Iffy et al. tables. Photographic documentation was made and then digitally processed in the Computer Image Digital Analysis System. The following parameters were taken into account: the length and width of 3 parts of the pancreas, namely the head, corpus and tail. Additionally, radiograms were made to obtain a projection of the gland on the vertebral column. Development of the pancreas was correlated with the age of the foetuses calculated on the basis of crown-rump (CR) lenght measurements. The correlation coefficient with CR was 0.998 for the pancreas length, 0.709 for the width of the head, 0.703 for the width of the corpus and 0.712 for the width of tail. Gender dimorphism was not found (p > 0.05) with regard to the morphometry of the pancreas. In the material under examination the pancreas did not change its position in relation to the vertebral column. The head projected on the vertebral column in the range Th₁₂–L₂ (most frequently L₁–L₂), the corpus on Th₁₂–L₂ and the tail on Th₁₁.

5

Histomorphological evaluation of fibrogenesis in the pancreas after an experimental administration of ethanol

88%

Pedrycz A., Boratynski Z., Kot K., Mendocha J., Rubaj J., Cichacz B., Plaskota W.

Bulletin of the Veterinary Institute in Puławy

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2008

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tom 52

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nr 3

The purpose of the presented study was the analysis of post-ethanol fibrogenesis in the pancreas, being one of the causes of exo- and endocrine pancreatic insufficiency. The study was performed on rats classified into a control and experimental group. The animals from the experimental group were given 20% ethyl alcohol solution ad libitum for 4 weeks. After decapitation of the animals, pancreatic segments were collected and histological sections of the segments stained with haematoxylin and eosin and with Masson's method for connective tissue were prepared. In the sections from the experimental group, a significant increase in the number of connective tissue fibres was observed. They were observed not only around the lumen of glandular ducts (as it was the case in the control group), but also among some vesicles and on the border of the pancreatic lobules. Their accumulation was also observed around the cells forming the pancreatic islets.

6

Secretion of pancreatic juice studied with cannulation of pancreatic duct in the pig

88%

Winnicki T., Brzeski W., Wasowski R.

Polish Journal of Veterinary Sciences

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1998

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tom 01

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nr 2

The following paper deals with the results of a long-lasting cannulation of the porcine pancreas performed using new methods. One method is based on a direct cannulation of the pancreatic duct after its incision. The other (designed by the authors) consists of a cannulation of the pancreas through the minor duodenal papilla. During the 14-day experimental period the efficiency of both methods was evaluated based upon certain indexes of the pancreatic juice secretions, including the level and daily dynamics of the secretions, as well as individual differentiations within two experimental groups. The method of cannulation through the minor duodenal papilla gave better results and a higher efficiency of the secretion, thus it was found to be more advantageous than the cannulation of the pancreatic duct after its incision.

7

Ganglionic cells and their localization within the secretory system of pancreas in vertebrates

88%

Gienc J., Kosierkiewicz D., Kuder T.

Zoologica Poloniae

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1993

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tom 38

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nr 1-4

8

In vivo visualization of epidermal growth factor receptor and survivin expression in porcine pancreas using endoscopic ultrasound guided fine needle imaging with confocal laser-induced endomicroscopy

75%

Nakai Y., Shinoura S., Ahluwalia A., Tarnawski A. S., Chang K. J.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 6

9

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The effect of antagonist of receptors for gastrin, cholecystokinin and bombesin on growth of gastroduodenal mucosa and pancreas

75%

Dembinski A., Warzecha Z., Konturek S. J., Banas M., Cai R.-Z., Schally A. V.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 3

The effects of gastrin, cholecystokinin (CCK) and bombesin on the DNA synthesis, as a biochemical indicator of trophic action in the gastroduodenal mucosa and the pancreas, have been examined in rats fasted for 48 h and in rats refed for 16 h with or without administration of specific receptor antagonists for bombesin, gastrin and CCK. Bombesin and gastrin administered three times daily for 48 h in fasted rats significantly increased the rate of DNA synthesis as measured by the incorporation of [³H] thymidine into DNA in each tissue tested. CCK significantly increased DNA synthesis in the duodenal mucosa and pancreatic tissue, but not in the gastric mucosa. The stimulation of DNA synthesis induced by bombesin in the gastroduodenal mucosa and pancreas was abolished by bombesin/GRP receptor antagonist, RC-3095. RC-3095 did not affect DNA synthesis stimulated by gastrin and CCK in these tissues. L-365,260, a receptor antagonist for gastrin suppressed the DNA synthesis induced by gastrin but not by CCK or bombesin in the gastrointestinal mucosa and pancreas. L-364,718, a specific antagonist for CCK receptors was effective only against CCK stimulated duodenal mucosa and pancreatic growth. Refeeding of 48 h fasting rats strongly enhanced the DNA synthesis in all tissues tested, and this effect was significantly reduced in the gastroduodenal mucosa by blocking only gastrin receptors (with L-365, 260) and that in the duodenal mucosa and the pancreas by antagonizing of CCK receptors (with L-364, 718). Antagonism of bombesin receptors (with RC-3095) did not significantly affect the stimulation of DNA synthesis induced by refeeding in all tissues tested. This study indicates that the stimulation of DNA synthesis can be achieved by exogenous gastrin, CCK and bombesin acting through separate receptors, but that only gastrin and CCK play the major role in the postprandial stimulation of the growth of gastroduodenal mucosa and pancreatic tissue.

10

Purinergic signaling in the pancreas and the therapeutic potential of ecto-nucleotidases in diabetes

75%

Cieslak M., Roszek K.

Acta Biochimica Polonica

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2014

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tom 61

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nr 4

11

Amino acid - induced insulin release from the perfused rat pancreas. The influence of phenylalanine and tyrosine

75%

Mackowiak P.

Acta Physiologica Polonica

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1990

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tom 41

|

nr 7

Maćkowiak P.: Amino acid-induced insulin release from the perfused irat pancreas. The influence of phenylalanine and tyrosine. Acta physiol, pol. The effects of L or D phenylalanine and L tyrosine on insulin release from the perfused rat pancreas were investigated. It was found that in the presence of D-glucose, all three amino-acids stimulate insulin secretion. After L-Phe had been removed from perfusate in the presence or absence of L-Tyr, the secondary rise of insulin release (an “off response”) was noticed. This phenomenon did not follow to either D-Phe or L-Tyr.

12

The pathogenesis and pathophysiology of acute pancreatitis

75%

Steer M. L.

Journal of Physiology and Pharmacology. Supplement

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1998

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tom 49

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nr 2

13

The effect of exogenous leptin on pancreatic enzyme secretion in anaesthetized rats

75%

Matyjek R., Wolinski J., Laubitz D., Kato S., Zabielski R.

Journal of Animal and Feed Sciences

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2005

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tom 14

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nr 2

14

The influence of differentiated feeding on enzymatic activity and elektrophoretic mobility of pancreatic soluble protein of chickens

75%

Makarski B., Masiulanis J., Liczmanski A. E.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1994

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tom 42

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nr 2

15

Immunocytochemical studies on pancreatic endocrine cell at early stages of development of the pig

75%

Zabel M., Surdyk-Zasada J., Lesisz I., Jagoda E., Wysocka T., Seidel J., Grzeszkowiak J.

Folia Histochemica et Cytobiologica

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1994

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tom 32

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nr 3

16

The sequential differentiation and formation of hepatic and pancreatic structures in asp [Aspius aspius L.] larvae

75%

Ostaszewska T.

Electronic Journal of Polish Agricultural Universities. Series Fisheries

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2002

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tom 05

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nr 1

The study focussed on differentiation of hepatic and pancreatic cells in asp (Aspius aspius L.) larvae during early ontogeny (121 days post hatch). Histological evaluations and histochemical assays showed the asp liver and pancreas to commence functioning almost simulatenously, between the third and the fifth day of larval life.

17

Elastase activity and histological changes in lungs and in pancreas due to experimental pancreatitis

75%

Maciejewski R., Madej B., Draus J., Jedrzejewska E., Juskiewicz W.

Folia Histochemica et Cytobiologica

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1999

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tom 37

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nr 2

18

Investigations on origin of alpha-amylase present in Ascaris suum intestine using immunodiffusion test

75%

Zoltowska K.

Acta Parasitologica

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1992

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tom 37

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nr 4

The provenance of α-amylase from intestines of adult Ascaris suum was investigated by Ouchterlony method using sera of guinea pigs vaccinated with the enzyme protein extracted from the worm intestine or pig pancreas. No cross-reactivity was observed between sera raised against pig α-amylase and A. suum enzyme. The results support suggestions that α-amylase present in A. suum intestine is produced by the nematode and not required from the host intestine.

19

Melatonin precursor, L-tryptophan protects the pancreas from development of acute pancreatitis through the central site of action

75%

Leja-Szpak A., Jaworek J., Tomaszewska R., Nawrot K., Bonior J., Kot M., Palonek M., Stachura J., Czupryna A., Konturek S. J., Pawlik W. W.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 1,2

Melatonin, produced from L-tryptophan, protects the pancreas against acute damage by improving the antioxidative status of tissue. Melatonin receptors have been detected in the brain, but the contribution of these receptors to the pancreatic protection is unknown. The aim of our study was to compare the effects of melatonin precursor; L-tryptophan given intracerebroventricularly (i.c.v.) or intraperitoneally (i.p.) on the course of acute pancreatitis. Acute pancreatitis was induced by subcutaneous infusion of caerulein (5µg/kg-h x 5h). L-tryptophan was given i.p. (2.5, 25 or 250 mg/kg) or administered into right cerebral ventricle (0.02, 0.2 or 2.0 mg/rat) 30 min prior to the start of caerulein infusion. Plasma amylase, lipase and TNF alpha activities were measured to determine the severity of caerulein-induced pancreatitis (CIP). The lipid peroxidation products: malonylodialdehyde and 4-hydroksynonenal (MDA + 4-HNE) and activity of superoxide dismutase (SOD) were measured in the pancreas of intact or CIP rats with or without L-tryptophan pretreatment. Melatonin blood level was measured by RIA. CIP was confirmed by histological examination and manifested as an edema and rises of plasma levels of amylase, lipase and TNF alpha (by 550%, 1000% and 600%). MDA + 4-HNE was increased by 600%, whereas SOD activity was reduced by 75% in the pancreas of CIP rats. All manifestations of CIP were significantly reduced by pretreatment of the rats with L-tryptophan given i.c.v. at doses of 0.2 or 2.0 mg/rat, or by peripheral administration of this amino acid used at dose of 250 mg/kg i.p. In control rats plasma level of melatonin averaged about 40 ± 2 pg/ml and was not significantly affected by CIP, by central application of L-tryptophan (0.02, 0.2 or 2.0 mg/rat) or by peripheral administration of this melatonin precursor used at doses of 2.5 or 25 mg/kg i.p. Plasma melatonin level was markedly increased by pretreatment of the rats with L-tryptophan given i.p. at dose of 250 mg/kg. We conclude that central administration of melatonin precursor; L-tryptophan, as well as peripheral application of high dose of this melatonin precursor prevented the pancreatic damage produced by CIP. The favorable effect of peripherally administered L-tryptophan could be related to the rise of melatonin plasma level and to pancreatoprotective action of this indoleamine. The beneficial effect of centrally administered L-tryptophan could be mediated through activation of central receptors for locally produced melatonin.

20

Ultrastructural evaluation of pancreatic parenchyma in the course of intoxication with ethanol

75%

Kot K., Boratynski Z., Pedrycz A., Mendocha J., Rubaj J., Cichacz B., Plaskota W.

Bulletin of the Veterinary Institute in Puławy

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2008

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tom 52

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nr 3

The experiment was performed on rats that were given ethanol ad libitum for 4 weeks. After decapitation of the animals, pancreatic sections were prepared for an electron microscopy. A significant broadening of the rough endoplasmic reticulum cisterns in the vesicular cells was observed as well as the presence of nuclei with irregular outlines resulted from placation of the nuclear membrane, which is worth of attention. Such a picture suggests that the examined cells had a lowered metabolic ability.

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