Lansoprazole, a known H+/K+-ATPase inhibitor, is currently used as a therapeutical option for the initial treatment of gastroesophageal reflux disease. Recently, lansoprazole has been found to be an inhibitor of cytosolic PHOSPHO1 (a phosphatase which hydrolyses phosphocholine and phosphoethanolamine), providing a possible therapeutical target to cure pathological mineralization. Since PHOSPHO1 is present inside matrix vesicles, we tested the effect of lansoprazole on matrix vesicles containing several key enzymes for the mineralization process including tissue-nonspecific alkaline phosphatase. We found that lansoprazole can inhibit in an uncompetitive manner tissue-nonspecific alkaline phosphatase. A Ki value of 1.74 ± 0.12 mM has been determined for the inhibition of tissue-nonspecific alkaline phosphatase by lansoprazole. Lansoprazole, currently used for treating gastroesophageal disease, by inhibiting PHOSPHO1 and tissue-nonspecific alkaline phosphatase could prevent hydroxyapatite-deposition disease and could serve as an adjunct treatment for osteoarthritis.
Infrared (IR)-A irradiation can be useful in back and musculoskeletal pain therapy. In this study joint and vertebral column pain and mobility were measured during two weeks of IR-A irradiation treatment of patients suffering from degenerative osteoarthritis of hip and knee, low back pain, or rheumatoid arthritis. Additionally, before and after IR-A treatment MDA serum levels were measured to check if MDA variations accompany changes in pain intensity and mobility. Two-hundred and seven patients were divided into verum groups getting IR-irradiation, placebo groups getting visible, but not IR irradiation, and groups getting no irradiation. In osteoarthritis significant pain reduction according to Visual Analogue Scale and mobility improvements occurred in the verum group. Even though beneficial mean value changes occurred in the placebo group, the improvements in the placebo and No Irradiation groups were without statistical significance. In low back pain, pain and mobility improvements (by 35-40 %) in the verum group were found, too. A delayed (2nd week) mobility improvement in rheumatoid arthritis was seen. However, pain relief was seen immediately. In patients suffering from low back pain or rheumatoid arthritis, the pain and mobility improvements were accompanied by significant changes of MDA serum levels. However, MDA appears not a sensitive biofactor for changes of the pain intensity in degenerative osteoarthritis. Nevertheless, unaffected or lowered MDA levels during intensive IR-A therapy argue against previous reports on free radical formation upon infrared. In conclusion, rapid beneficial effects of IR-A towards musculoskeletal pain and joint mobility loss were demonstrated.
Radiographic and clinical studies, coupled with biomechanical assessment of the hip, are important tools for predicting the development of osteoarthitis of the hip. In order to better understand the treatment of hip dysplasia, it is necessary to determine the contact stress in the hip joint. In this study, a three-dimensional mathematical model was used to determine hip joint contact stress. Because of the discrepancy in the results of analyses of different radiographic indicators of hip dysplasia, the calculation of hip joint contact stress is proposed for a more accurate assessment of the severity of hip dysplasia.
The decrease in contact hip joint stress after Chiari osteotomy is studied using a mathematical model. In the model, additional coverage of the femoral head by the ala ossis ilei segment is taken into account. It is shown that this additional coverage significantly decreases stress, mostly by the indirect effect caused by the shift of the stress pole.
Osteoporosis and osteoarthrosis are the most common diseases of bone tissue affecting both rural and urban populations. The aim of the study was to investigate the level of education and requirement for health promotion within the scope of common diseases of the skeletal system among rural population in Poland. This was an exploratory study with a cross-sectional design performed between May 2004–September 2005 in rural areas of 16 Voivodeships (main provinces) of Poland. The study population comprised of 404 (62.9%) rural women and 238 (37.1%) rural men (total 642). All subjects were randomly sampled and recruited by personal contact in primary health care centres. Study data were obtained using a specially prepared questionnaire. The most commonly reported diseases were: arterial hypertension (26.1%), joint degenerative disease (24.6%) and osteoarthritis (14.7%). The occurrence of osteoarthritis and joint degenerative disease increased with age and was highest in the group aged over 50 (21% and 38.7% respectively). Osteoarthitis was more frequent in women compared to men (16% and 12.2% respectively). In most cases, the basic information about methods of prevention and treatment given by a General Practitioner or a specialist was characterized as “satisfactory” (73.6% and 62.9% respectively). The most popular prophylactic action performed in local communities was bone densitometry (14.1%), and the most important source of knowledge - TV and radio (65%). Populations living in rural areas have limited access to health education and health prophylaxis actions, irrespective of the geographical region of Poland. Inhabitants with secondary or higher education, as well as those with a higher household income, have better knowledge about skeletal system diseases compared to those with a lower educational level. The practical implications of this study suggest the necessity for paying more attention to etiology, symptoms and methods of prevention and treatment of bone diseases when attending to patients in specialist practice.
17
Dostęp do pełnego tekstu na zewnętrznej witrynie WWW
This paper describes the results of Chiari osteotomy (CO) with simultaneous intertrochanteric osteotomy (IO) in dogs affected by bilateral hip dysplasia, score grade D. The dogs classified for the study were subjected to the following tests before and after surgery: abduction-external rotation test, hip extension test, dorso-lateral subluxation test (DLST), stand test, Ortolani sign, Barlow sign, measurements of the angle of flexion, angle of extension, angle of abduction, angle of adduction, and radiographic examinations determining the score grade for canine hip dysplasia in accordance with the scoring system recommended by the Fédération Cynologique Internationale. The test which most accurately reflected the post-operative improvement in patients was DLST where the negative response increased by 73% after CO and IO procedures. Changes in angle of inclination (AI) values were correlated with an improvement in hip functioning as a result of the administered treatment. The simultaneous application of CO and IO in dogs affected by hip dysplasia resulted in greater improvement of limb functioning in comparison with conventional IO.
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.