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Modulation of testicular functions by testicular opioid peptides

100%

Gerendai I.

Journal of Physiology and Pharmacology

1991

tom 42

nr 4

The possible physiological role of testicular opioid peptides in the control of testicular functions has been studied. In neonatal rats in tratest icular administration of opiate receptor antagonists (naloxone, nalmefene) stimulates Sertoli cell proliferation and secretion. Both in adult and neonatal rats local injection of the testis with opiate receptor antagonists or with ß-endorphin antiserum results in a decrease in steroidogenesis in long-term studies. Treatment of neonatal testis with an enkephalin analogue induces a short-term suppression of testosterone secretion. Further studies were carried out to investigate whether the above described local effects of opiate agonist or antagonist on testicular function are under the regulatory control of testicular nerves. Partial denervation of the testis was performed by testicular injection of 6-hydroxydopamine (a neurotoxin degenerating sympathetic neural structures) or by vasectomy (cutting the inferior spermatic nerve). If testicular administration of opioid agonist or antagonist was combined with partial denervation of the testis, the effects of pharmacological agents influencing testicular opioid level were not evident. The data indicate that opioid peptides synthesized in the testis are components,of the intratest icular regulatory system and that local opioid actions are modulated by testicular nerves.

Ograniczanie wyników

1 Journal of Physiology and Pharmacology

1 Gerendai I.

1 1991

Wyniki wyszukiwania

Modulation of testicular functions by testicular opioid peptides