Wyniki wyszukiwania - AGRO

1

Nucleic acid aptamers in human viral disease

100%

Zhang Z., Blank M., Schluesener H. J.

Archivum Immunologiae et Therapiae Experimentalis

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2004

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tom 52

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nr 5

2

Localization of calcitonin mRNA using in situ labeling with reverse transcriptase and PCR

100%

Zabel M., Ciesielska U., Wysocka T.

Folia Histochemica et Cytobiologica. Supplement

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1996

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tom 34

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nr 1

3

Interaction of higher plant ribosomal 5S RNAs with Xenopus laevis transcriptional factor IIIA

100%

Barciszewska M. Z.

Acta Biochimica Polonica

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1994

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tom 41

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nr 1

In this paper transcriptional factor IDA (TFIIIA) has been used as a probe for identity of three-dimensional-structure of eukaryotic 5S rRNAs. I was interested in finding a common motif in plant and Xenopus 5S rRNAs for TFIIIA recognition. I found that the two eukaryotic 5S rRNAs (from wheat germ and lupin seeds) are recognized by X. laevis TFIIIA and the data clearly suggest that these 5S rRNAs have very similar if not identical three-dimensional structures. Also effects of various conditions on stability of these complexes have been studied.

4

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Development of hammerhead ribozymes targeting miR-21

86%

Belter A., Naskret-Barciszewska M. Z.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2014

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tom 95

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nr 4

5

Hybridocytochemistry - state of the art

86%

Van Der Ploeg M.

Postępy Biologii Komórki

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1989

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tom 16

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nr 4

6

Cytophotometric estimation of nucleic acids and computer image analysis of the nuclei in the cell cycle phases

86%

Krygier-Stojalowska A., Joachimiak H., Gapski Z.

Folia Histochemica et Cytobiologica

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1984

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tom 22

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nr 3-4

7

Purification of tobacco (Nicotiana tabacum L.) specific transfer ribonucleic acids. Partial nucleotide sequence of initiator tRNA

86%

Barciszewska M., Kaniewski W., Pietrzak M., Barciszewski J.

Prace Naukowe Instytutu Ochrony Roślin

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1984

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tom 26

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nr 2

8

Tautomerism of thioguanine. Experimental matrix isolation and theoretical quantum-mechanical studies

86%

Szczepaniak K., Person W. B., Leszczynski J., Kwiatkowski J. S.

Postępy Biochemii

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1995

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tom 41

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nr 5

9

Viral genomes and their replication strategies

86%

Lisowski P., Kleczkowski M., Jakubczak A.

Advances in Agricultural Sciences

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2004

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tom 09

10

Short, 12 mer fluorescently labeled methylphosphonated oligonucleotides to visualize beta-actin mRNA in vivo

86%

Lazowski K. W., Kaczmarek L.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 4

A pair of fluorescently labeled antisense ( complementary to ß-actin mRNA) or control methylphosphonated DNA 12-mers were introduced into live cells. After fixation their distribution throughout the cell was compared to the localization pattern for the pair of control oligos.The distribution of the two sets of oligos differed in that there was a distinct pool of antisense probes that were detected at elevated levels in the leading edge of fibroblast and cortical underlining. The resulting fluorescence patterns of antisense probes colocalized and were analogous to labeling pattern already described and produced by in situ hybridization . The length of each of the probe destabilized binding to mismatched sequences at physiological temperature, while the overall length of the pair gave a unique, highly sequence specific recognition of a target sequence. Simultaneous, in vivo application of multiple probes let include internal controls into the experimental setup, in order to distinguish different distributions of antisense and control probes in the same specimen.

11

Peptide nucleic acids and their structural modifications

86%

Falkiewicz B.

Acta Biochimica Polonica

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1999

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tom 46

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nr 3

Peptide (polyamide) analogues of nucleic acids (PNAs) make very promising groups of natural nucleic acid (NA) ligands and show many other interesting properties. Two types of these analogues may be highlighted as particularly interesting: the first, containing a polyamide with alternating peptide/pseudopeptide bonds as its backbone, consisting of N-(aminoalkyl)aminoacid units (typeI), with nucleobases attached to the backbone nitrogen with the carboxyalkyl linker; and the second, containing a backbone consisting of amino-acid residues carrying the nucleobases in their side chains (type II). So far, these two groups have been studied most intensively. The paper describes main groups of peptide nucleic acids, as well as various other amino acid-derived nucleobase monomers or their oligomers, which were either studied in order to determine their hybridisation to nucleic acids, or only discussed with respect to their potential usefulness in the oligomerisation and nucleic acids binding.

12

Non-glycerol based lipofectins for gene delivery

86%

Rao N. M., Chaudhuri A.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr 2

13

Is it possible to order the clusters of viruses and the families of viruses of vertebrates in a way that provides the evolutional connections between the type and the class of nucleic acids forming viral genomes?

86%

Malicki K.

Bulletin of the Veterinary Institute in Puławy

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1998

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tom 42

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nr 1

14

Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?

86%

Nawrot B.

Acta Biochimica Polonica

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2004

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tom 51

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nr 2

ß-Secretase, a ß-site amyloid precursor protein (APP) cleaving enzyme (BACE), participates in the secretion of ß-amyloid peptides (Aß), the major components of the toxic amyloid plaques found in the brains of patients with Alzheimer's disease (AD). According to the amyloid hypothesis, accumulation of Aß is the primary influence driving AD pathogenesis. Lowering of Aß secretion can be achieved by decreasing BACE activity rather than by down-regulation of the APP substrate protein. Therefore, ß-secretase is a primary target for anti-amyloid therapeutic drug design. Several approaches have been undertaken to find an effective inhibitor of human ß-secretase activity, mostly in the field of peptidomimetic, non-cleavable substrate analogues. This review describes strategies targeting BACE mRNA recognition and its down-regulation based on the antisense action of small inhibitory nucleic acids (siNAs). These include antisense oligonucleotides, catalytic nucleic acids — ribozymes and deoxyribozymes — as well as small interfering RNAs (siRNAs). While antisense oligonucleotides were first used to identify an aspartyl protease with S-secretase activity, all the strategies now demonstrate that siNAs are able to inhibit BACE gene expression in a sequence-specific manner, measured both at the level of its mRNA and at the level of protein. Moreover, knock-down of BACE reduces the intra- and extracellular population of Aß40 and Aß42 peptides. An anti-amyloid effect of siNAs is observed in a wide spectrum of cell lines as well as in primary cortical neurons. Thus targeting BACE with small inhibitory nucleic acids may be beneficial for the treatment of Alzheimer’s disease and for future drug design.

15

The occurrence of hop latent viroid [HLVd] in hop plants in Poland

86%

Solarska E., Skomra U., Kitlinska J., Wojcierowski J.

Phytopathologia Polonica

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1995

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tom 10

16

Degradation products of nucleic acids in wines fermented with dried autolysate of sedimented wine yeast

86%

Pogorzelski E., Laskowska J., Czyzowska A.

Polish Journal of Food and Nutrition Sciences

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2006

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tom 15/56

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nr 2

The study aimed at determining and comparing the levels of degradation products of nucleic acids and fermentation yield of apple wines fermented with stimulators obtained from sedimented wine yeast. It was demonstrated that increasing doses of yeast autolysate added to wine pitching resulted in an elevated concentration of purine bases (adenine and guanine), pyrimidine bases (thymine, cytosine, uracil), and uric acid. Compared to the control sample fermented only with diammonium phosphate, the samples fermented with autolysate applied at a dose of 4.5 g/L pitching (100 mg/L when converted into α-amino acid nitrogen) were characterised by twice as high concentrations of purine and pyrimidine bases and uric acid. The total content of those compounds did not exceed 11.4 mg/L of wine.

17

The decisive role of the water structure in changes of conformation of nucleic acids

86%

Barciszewski J., Jurczak J., Porowski S., Specht T., Erdmann V. A.

Acta Biochimica Polonica

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1999

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tom 46

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nr 1

This review summarizes data on the structure and properties of water under normal conditions, at high salt concentration and under high pressure. We correlate the observed conformational transitions in nucleic acids with changes in water structure and activity, and suggest a mechanism of conformational transitions of nucleic acid involving these changes. We conclude that the Z-DNA form is induced only at low water activity caused by high salt concentrations and/or high pressure.

18

Nonenzymatic hydrolysis of oligoribonucleotides. V. The elements affecting the process of self-hydrolysis

86%

Bibillo A., Ziomek K., Figlerowicz M., Kierzek R.

Acta Biochimica Polonica

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1999

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tom 46

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nr 1

Chemical instability of some of the phosphodiester bonds, often observed in large RNAs, visualizes the autocatalytic properties of this class of nucleic acids. Unexpectedly, selective hydrolysis occurs also in short oligoribonucleotides (as short as a tet- ramer or hexamer). Herein, we describe additional experiments which support the conclusion that the hydrolysis is not due to ribonuclease contamination but is of autocatalytic origin and is related to the sequence and structure of single-stranded oligomers. Moreover, we show that the presence in the reaction mixture of poly- amines, such as spermidine, is essential for hydrolysis of oligoribonucleotides.

19

Teratogenic effects of chlormethine hydrochloride in rats

86%

Anasiewicz A.

Folia Morphologica

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1996

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tom 55

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nr 4

20

A-Z conformational changes effected in RNA by high pressure

86%

Krzyzaniak A., Furste J. P., Salanski P., Jurczak J., Erdmann V. A., Barciszewski J.

Acta Biochimica Polonica

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1993

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tom 40

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nr 1

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