Wyniki wyszukiwania

1

Elevated serum osteoprotegerin is associated with decreased osteoclastic differentiation in stenotic aortic valves

100%

Lis G. J., Czubek U., Jasinska M., Jasek E., Laboda A., Dulak J., Nessler J., Sadowski J., Litwin J. A.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 3

2

TNFalpha-induced activation of NFkappaB protects against UV-induced apoptosis specifically in p53-proficient cells

86%

Szoltysek K., Pietranek K., Kalinowska-Herok M., Pietrowska M., Kimmel M., Widlak P.

Acta Biochimica Polonica

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2008

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tom 55

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nr 4

741-748

The signaling pathways that depend on p53 or NFκB transcription factors are essential components of cellular responses to stress. In general, p53 is involved in either activation of cell cycle arrest or induction of apoptosis, while NFκB exerts mostly anti-apoptotic functions; both regulatory pathways apparently interfere with each other. Here we aimed to analyze the effects of NFκB activation on DNA damage-induced apoptosis, either p53-dependent or p53-independent, in a set of human cell lines. Four cell lines, HCT116 and RKO colon carcinoma, NCI-H1299 lung carcinoma and HL60 myeloblastoma, each of them in two congenic variants either containing or lacking transcriptionally competent p53, were used. Cells were incubated with TNFα cytokine to activate NFκB and then treated with ultraviolet or ionizing radiation to induce apoptosis, which was assessed by measurement of the sub-G1 cell fraction. We observed that treatment with TNFα resulted in a significant reduction in the frequency of apoptotic cells in UV-irradiated p53-proficient lines (with exception of the UV-resistant NCI-H1299 cells). This anti-apoptotic effect was lost when cells were pretreated with parthenolide, an inhibitor of NFκB activation. In marked contrast, TNFα-pretreatment of p53-deficient lines resulted in an increased frequency of apoptotic cells after UV irradiation (with exception of HL60 cells). Such anti- and pro-apoptotic influence of TNFα was less obvious in cells treated with ionizing radiation. The data clearly indicates functional interference of both signaling pathways upon the damage-induced apoptotic response, yet the observed effects are both cell type- and stimulus-specific.

3

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Hydrogen sulfide modulates gastric acid secretion in rats via involvement of substance P and nuclear factor-kappaB signaling

86%

Sun H.-Z., Gong X.-Y., Wu L., Wang X.-X., Nie Y.-N., Shang R., Wang H., Li Y.-C., Sun Q.-F., Gao P.-F., Bi J.-X.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 3

4

Regulatory effects of 1,25-dihydroxyvitamin D3 on vascular smooth muscle cells

86%

Tukaj S., Trzonkowski P., Tukaj C.

Acta Biochimica Polonica

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2012

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tom 59

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nr 3

Inflammatory response has been recognized as a central feature in the development and progression of atherosclerosis, and VSMCs (Vascular Smooth Muscle Cells) - the main cellular component of media, play an important role in this process. Many reports indicate that the biologically active vitamin D metabolite - 1,25-dihydroxyvitamin D3 (1,25(OH)2D3 = calcitriol), besides its well established role in calcium homeostasis, plays an essential role in the regulation of the inflammation process. The aim of this study was to determine the regulatory effects of calcitriol, applied at two supra-physiological doses (10 nM and 100 nM), in VSMC culture. Secretion of the pro-inflammatory cytokines, IL-6 and TNF-α, was significantly attenuated in calcitriol-treated VSMC culture, but the level of anti-inflammatory TGF-β was generally unchanged. Since in advanced atherosclerosis lesions several cell types, including VSMCs, overproduce the HSP70 chaperone protein, we also checked the effects of calcitriol on its synthesis. The presence of 1,25(OH)2D3 did not affect HSP70 synthesis under physiological conditions but the synthesis of HSP70 in VSMCs exposed to heat shock was significantly inhibited by calcitriol (=100 nM). We observed that 1,25(OH)2D3 induced SOD 1 activity, stimulated the expression of IκB-α, and did not influence the level of NF-κB-p65 in VSMCs. The results of our study suggest that 1,25(OH)2D3 may serve as a natural anti-inflammatory agent and may therefore play a beneficial role in the physiology of VSMC in some contexts of atherosclerosis.

5

The role of nuclear factor-kappaB in the development of autoimmune diseases: a link between genes and environment

86%

Kurylowicz A., Nauman J.

Acta Biochimica Polonica

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2008

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tom 55

|

nr 4

629-647

Although autoimmune diseases are relatively common, mechanisms that lead to their development remain largely unknown. Nuclear factor-κB (NF-κB), as a key transcription factor involved in the regulation of immune responses and apoptosis, appears to be a good candidate for studies on the pathogenesis of autoimmunity. This review presents how perturbations of the NF-κB signaling pathway may contribute to self-tolerance failure, initiation of autoimmune inflammatory response as well as its persistent maintenance and therefore to the development of common autoimmune diseases including rheumatoid arthritis, multiple sclerosis, type 1 diabetes mellitus, thyroid autoimmune diseases, systemic lupus erythematosus as well as inflammatory bowel diseases and psoriasis. A special emphasis is put on the genetic variations in the NF-κB related genes and their possible association with susceptibility to autoimmune diseases, as well as on the therapeutic potential of the NF-κB targeted strategies in the treatment of autoimmunity

6

Involvement of epithelial-mesenchymal transition-inducing transcription factors in the mechanism of Helicobacter pylori-induced fibroblasts activation

86%

Krzysiek-Maczka G., Targosz A., Szczyrk U., Strzalka M., Brzozowski T., Ptak-Belowska A.

Journal of Physiology and Pharmacology

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2019

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tom 70

|

nr 5

7

Manipulation of non-canonical NF-κB signaling by non-oncogenic viruses

86%

Struzik J., Szulc-Dabrowska L.

Archivum Immunologiae et Therapiae Experimentalis

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2019

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tom 67

|

nr 1

8

Evidence of TWIST1 and transforming growth factor-beta1 aberrant expressions as novel therapeutic targets in modulating the severity of osteoarthritis with focus on biologic agents

86%

Ye C., Ye J., Wu H., Zhang F., Liu Y.

Journal of Physiology and Pharmacology

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2020

|

tom 71

|

nr 6

9

Effect of unfractionated heparin, enoxaparin and sulodexide on the relations between secretion and expression of OPG, RANKL and vWF in HUVEC

72%

Lekesiz K., Naumnik B., Borysewicz-Sanczyk H., Koc-Zorawska E., Mysliwiec M.

Folia Histochemica et Cytobiologica

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2013

|

tom 51

|

nr 2

10

Growth of breast cancer cells inhibited by bromelains extracted from the different tissues of pineapple

72%

Haiyan S., Funing M., Keming L., Wei S., Guiying X., Rulin Z., Shenghe C.

Folia Biologica

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2020

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tom 68

|

nr 3

11

Pancreatitis-associated protein-1 suppresses apoptosis in cerulein-stimulated pancreatic acinar cells in response to nuclear factor-kappaB activation

72%

Yu J. H., Lim J. W., Kim H.

Journal of Physiology and Pharmacology

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2019

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tom 70

|

nr 6

12

The role of reactive nitrogen species and cigarette smoke in activation of transcription factor NF-kappaB and implication to inflammatory processes

72%

Bar-Shai M., Hasnis E., Wiener-Megnazi Z., Reznick A. Z.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

|

nr 4

39-44

Using the electromobility shift assay (EMSA) in the rat myoblast system, the activation of transcription factor NF-B by reactive nitrogen species was evaluated. Two distinct patterns of activation were demonstrated. Whereas NO donor, SNAP, activated NF-B in the classical pathway, which led to a transient response, NF-B activation by peroxynitrite donor, SIN-1, was mediated by an alternative pathway, which has been demonstrated in previous works to involve tyrosine nitration of the NF-B inhibitory protein I-Balpha. This led to a constitutive non-transient activation of NF-B and a prolonged inflammatory reaction. Lymphocytes exposed to mild intensity of cigarette smoke for 8 h, which activated NF-B, exhibited a decrease in the fraction of apoptotic cells from 27% to 19% compared with lymphocytes exposed to atmospheric air, using the FACS Annexin V assay. This also has been shown in previous works to be mediated by peroxynitrite. Thus, mild exposure to cigarette smoke induces NF-B activation, which can attenuate apoptosis in human lymphocytes and lead to prolonged inflammatory response. A possible proposed mechanism for induction of chronic inflammatory response may involve peroxynitrite-induced activation of NF-B.

13

Immunotherapy of sepsis: blind alley or call for personalized assessment?

72%

Prucha M., Zazula R., Russwurm S.

Archivum Immunologiae et Therapiae Experimentalis

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2017

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tom 65

|

nr 1

14

Mitochondria as oxidative signalling organelles in T-cell activation: physiological role and pathological implications

72%

Kaminski M. M., Roth D., Krammer P. H., Gulow K.

Archivum Immunologiae et Therapiae Experimentalis

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2013

|

tom 61

|

nr 5

15

Dysregulation of the receptor activator of NF-kappaB ligand and osteoprotegerin production influence the apoptosis of multiple myeloma patients' bone marrow stromal cells co-cultured with myeloma cells

72%

Zdzisinska B., Bojarska-Junak A., Walter-Croneck A., Kandefer-Szerszen M.

Archivum Immunologiae et Therapiae Experimentalis

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2010

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tom 58

|

nr 2

153-163

16

Exogenous administration of visfatin affects cytokine secretion and increases oxidative stress in human malignant melanoma Me45 cells

72%

Budlak R. J., Polaniak R., Buldak L., Mielanczyk L., Kukla M., Skonieczna M., Dulawa-Buldak A., Matysiak N., Zwirska-Korczala K.

Journal of Physiology and Pharmacology

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2013

|

tom 64

|

nr 3

17

OPG-RANK-RANKL signaling system and its significance in nephrology

72%

Klejna K., Naumnik B., Gasowska K., Mysliwiec M.

Folia Histochemica et Cytobiologica

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2009

|

tom 47

|

nr 2

199-206

18

The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis

72%

Kowalczyk A., Kleniewska P., Kolodziejczyk M., Skibska B., Goraca A.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

|

nr 1

19

Extracellular vesicles in follicular fluid of sexually mature gilts’ ovarian antral follicles - identification and proteomic analysis

72%

Grzesiak M., Popiolek K., Knapczyk-Stwora K.

Journal of Physiology and Pharmacology

|

2020

|

tom 71

|

nr 1

20

Hydrogen sulfide in the nucleus tractus solitarii regulates gastric acid secretion in rats

72%

Sun H., Yang J., Shi Y., Wang Y., Li C., Zhu M.

Journal of Physiology and Pharmacology

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2020

|

tom 71

|

nr 4

Ograniczanie wyników

Elevated serum osteoprotegerin is associated with decreased osteoclastic differentiation in stenotic aortic valves

TNFalpha-induced activation of NFkappaB protects against UV-induced apoptosis specifically in p53-proficient cells

Hydrogen sulfide modulates gastric acid secretion in rats via involvement of substance P and nuclear factor-kappaB signaling

Regulatory effects of 1,25-dihydroxyvitamin D3 on vascular smooth muscle cells

The role of nuclear factor-kappaB in the development of autoimmune diseases: a link between genes and environment

Involvement of epithelial-mesenchymal transition-inducing transcription factors in the mechanism of Helicobacter pylori-induced fibroblasts activation

Manipulation of non-canonical NF-κB signaling by non-oncogenic viruses

Evidence of TWIST1 and transforming growth factor-beta1 aberrant expressions as novel therapeutic targets in modulating the severity of osteoarthritis with focus on biologic agents

Effect of unfractionated heparin, enoxaparin and sulodexide on the relations between secretion and expression of OPG, RANKL and vWF in HUVEC

Growth of breast cancer cells inhibited by bromelains extracted from the different tissues of pineapple

Pancreatitis-associated protein-1 suppresses apoptosis in cerulein-stimulated pancreatic acinar cells in response to nuclear factor-kappaB activation

The role of reactive nitrogen species and cigarette smoke in activation of transcription factor NF-kappaB and implication to inflammatory processes

Immunotherapy of sepsis: blind alley or call for personalized assessment?

Mitochondria as oxidative signalling organelles in T-cell activation: physiological role and pathological implications

Dysregulation of the receptor activator of NF-kappaB ligand and osteoprotegerin production influence the apoptosis of multiple myeloma patients' bone marrow stromal cells co-cultured with myeloma cells

Exogenous administration of visfatin affects cytokine secretion and increases oxidative stress in human malignant melanoma Me45 cells

OPG-RANK-RANKL signaling system and its significance in nephrology

The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis

Extracellular vesicles in follicular fluid of sexually mature gilts’ ovarian antral follicles - identification and proteomic analysis

Hydrogen sulfide in the nucleus tractus solitarii regulates gastric acid secretion in rats