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1

Gut microbiota in neurological disorders

100%
Grochawska M., Laskus T., Radkowski M.
Archivum Immunologiae et Therapiae Experimentalis
|
2019
|
tom 67
|
nr 6
2

The role of microRNAs in neurological disorders

100%
Dulak J.
Acta Neurobiologiae Experimentalis
|
2013
|
tom 73
|
nr 1
microRNAs regulate all the cellular processes, and are strongly involved in differentiation of stem cells. Disturbances in the regulation of microRNAs expression and activity may deviate the stem cells fate, impairing their differentiation and contributing to diseases initiation or progression. In this talk the role of microRNAs in certain neurological conditions will be discussed.
3

Enzyme activities of purine metabolism in neurological disorders

100%
Tozzi M. G., Pesi R., Camici M., Jacomelli G., Peruzzi L., Micheli V.
Cellular and Molecular Biology Letters
|
1999
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tom 04
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nr 3
4

Effect of electromagnetic field exposure on mouse brain morphological and histopathological profiling

84%
Zymantiene J., Juozaitiene V., Zelvyte R., Oberauskas V., Spancerniene U., Sederevicius A., Aniuliene A.
Journal of Veterinary Research
|
2020
|
tom 64
|
nr 2
5
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Equine herpesvirus type 1 (EHV-1) replication in primary murine neurons culture

84%
Cymerys J., Dzieciatkowski T., Slonska A., Bierla J., Tucholska A., Chmielewska A., Golke A., Banbura M. W.
Polish Journal of Veterinary Sciences
|
2010
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tom 13
|
nr 4
Equine herpesvirus-1 (EHV-1) infections cause significant economic losses for equine industries worldwide as a result of abortion, respiratory illness, and neurologic disease in all breeds of horses. The occurrence of abortions caused by EHV-1 has repeatedly been confirmed in Poland, but neurological manifestations of the infection have not been described yet. Also it is unknown how the infection of neurons with non-neuropathogenic strains is regulated. To further understand the virus- neuron interaction we studied two strains of EHV-1 in murine primary neuron cell cultures. Both strains were isolated from aborted fetuses: Rac-H, a reference strain isolated by Woyciechowska in 1959 (Woyciechowska 1960) and Jan-E isolated by Bańbura et al. (Bańbura et al. 2000). Upon infection of primary murine neuronal cell cultures with Jan-E or Rac-H strains, a cytopathic effect was observed, manifested by a changed morphology and disintegration of the cell monolayer. Positive results of immunofluorescence, nPCR and real-time PCR tests indicated high virus concentration in neurons, meaning that both EHV-1 strains were likely to replicate in mouse neurons in vitro without the need for adaptation. Moreover, we demonstrated that some neurons may survive (limited) virus replication during primary infection, and these neurons (eight weeks p.i.) harbour EHV-1 and were still able to transmit infection to other cells.
6
Content available remote

Expression of neurotrophins and their receptors in human CD34plus bone marrow cells

84%
Paczkowska E., Piecyk K., Luczkowska K., Kotowski M., Roginska D., Pius-Sadowska E., Oronowicz K., Ostrowski M., Machalinski B.
Journal of Physiology and Pharmacology
|
2016
|
tom 67
|
nr 1
7

Role of immune-derived diffusible mediators in AIDS-associated neurological disorders

84%
Ensoli F., Fiorelli V., De Cristofaro M., Muratori D. S., Novi A., Isgro A., Aiuti F.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
tom 48
|
nr 4
8

Problem ortopedyczny czy neurologiczny? Jak rozszyfrować nieprawidłowości chodu

67%
Packer R. A.
Weterynaria po Dyplomie
|
2020
|
tom 21
|
nr 1
9

Intracerebral transplantation of human umbilical cord blood-derived neural stem cells (HUCB-NSC) in rats after focal brain ischemia ameliorates tissue expression of endogenous and exogenous neurotrophic factors

67%
Jablonska A., Drela K., Wojcik-Stanaszek L., Wanacka E., Zalewska T., Lukomska B.
Acta Neurobiologiae Experimentalis
|
2013
|
tom 73
|
nr 1
There is a great interest in the possibility of repairing the nervous system by transplantation new cells that can replace those lost through damage in neurological disorders. Key functions such as the replacement of neural cells have been recently challenged by intrinsic bystander capacities of undifferentiated donor cells to restore these cells. A comprehensive knowledge how transplanted stem cells exert their therapeutic achievements is still lacking. Here we investigated the effects of HUCB-NSC infused into the damaged rat brain at 72 h post ischemia on endogenous neurogenesis. The goal of our studies was to examine the proliferation and migration of host progenitor cells, analyze the substantial matrix remodeling of tissue and the presence of neurotrophic factors in rat brain after focal ischemia followed by HUCB-NSC transplantation. Methods: 2×104 HUCB-NSC were transplanted into corpus callosum of naive or focally injured rat brain 3 days after ischemic insult. At 1, 3, 7 and 14 days rat brains were removed. Endogenous cell proliferation was determined by BrdU incorporation. Then immunocytochemical analysis of doublecortin (DCX) and PSA-NCAM (markers expressed by immature migratory neuroblasts), and in situ zymography of MMPs activity was performed. Additionally, total RNA was isolated from rat brain tissue and RTPCR was performed using sets of primers of each of human and rat neurotrophic factor genes. Results: OUA-induced brain lesion resulted in increase of proliferating (BrdU+) and migrating (DCX+ and PSA-NCAM+) cells in subventricular zone (SVZ) and subgranular zone (SGZ) regions in comparison to intact rats. This response has been potentiated by HUCB-NSC transplantation. At 7th day after HUCB-NSC infusion the intense migration of DCX+cells from SVZ towards ischemic boundary regions of the striatum was observed. Moreover, the activation of MMPs in cells was visible in SVZ. Double-labeling showed co-localization of DCX marker with MMPs activity. The presence of MMPs appeared to be associated with cell nuclei and cytoplasm but interestingly it was also seen outside the cell bodies and in the neuronal protrusions. In OUAinduced lesion rat brain tissue, the expression pattern of rat-origin neurotrophic factors mRNA was higher than in intact rats. HUCBNSC transplantation into focal brain ischemic tissue significantly increased mRNA expression of several rat-origin growth factors, such as GDNF, CNTF responsible for regulation of proliferation and maturation of stem cells as well as IGF-1, HGF and presaposin functioning as anti-apoptotic mediators. The significant increment was observed 7 days after HUCB-NSC infusion. Using Real Time PCR method we were able to detect the presence of mRNA of BDNF, GDNF, NT3, IGF-1, HGF, semaphorin and presaposin of human-origin factors in the rat brain recipients of HUCB-NSC grafts. Conclusions: Transplantation of HUCB-NSC triggers early expansion of endogenous progenitor pool increasing fraction of proliferating cells in SVZ and SGZ of brain ischemic rats. Proteolytic activity of MMPs in extracellular compartment suggests its ability to remodel extracellular matrix and facilitate migration of neuroblasts to the damaged brain areas. The mechanism promoting recovery from ischemic injury remains to be clarified, although it is likely that it might be due to HUCB-NSC graft-induced release of neurotrophic factors by the host cells as well as the presence of human neural stem cells derived factors. Supported by MMRC statutory fund.
10

Determinants of plasma homocysteine in coal miners

67%
Mungan A. G., Can M., Kiran S., Acikgoz S., Guven B.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 3
Aim: Several studies suggest that coal miners are under risk of severe health problems such as cardiovascular, pulmonary, neurological, renal, hematological and musculoskeletal disorders. However, there are limited data on biochemical changes in underground workers. In our study we aimed to evaluate the association between serum homocysteine (Hcy), vitamin B12, cystatin C and folate levels in the blood of underground coal miners. Materials and Methods: Eighty one coal miners who work as underground or surface workers were recruited into our study. The study population was divided into two groups: the surface worker group (control group, n=33) and the underground worker group (n=48). The folate, vitamin B12, Hcy, cystatin C levels and body mass indexes (BMI) of both groups were measured and compared. Serum folate, Hcy and vitamin B12 levels were measured with a competitive chemiluminescence immunassay. Serum levels of cystatin C were determined by the latex particle-enhanced turbidimetric method using a cystatin C kit. Urea values were measured with a kinetic method on an automated analyzer. Results: There were no statistically significant differences between the underground workers and surface workers in the urea, cystatin C and vitamin B12 levels. High serum Hcy levels and low folate levels were found in underground workers compared with those in surface workers. The correlation between Hcy and folate levels was also statistically significant. Similarly, there was also a significant correlation between Hcy and vitamin B12, and between Hcy and cystatin C levels. Conclusions: Elevated Hcy levels may be associated with underground working but further research is necessary to understand the relation between elevated Hcy and increased prevalence of health problems in coal miners.
11
Content available remote

Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease

67%
Majewski M., Kozlowska A., Thoene M., Lepiarczyk E., Grzegorzewski W. J.
Journal of Physiology and Pharmacology
|
2016
|
tom 67
|
nr 1
12

Zagrożenia podczas znieczulenia ogólnego u koni

43%
Siwinska N., Przewozny M.
Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii
|
2015
|
tom 10
|
nr 2
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