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1

Potential suppressor gene loci and human prostate neoplasms

100%
Brys M., Krajewska W. M.
Cellular and Molecular Biology Letters
|
1997
|
tom 02
|
nr 4
The biology of prostate cancer is still poorly understood. Allelic loss studies indicate that there likely exist multiple sites harbouring candidate tumour suppressor genes (TSG), some of which may have an important role in primary tumours, and some in late stages of prostate cancer. The recent studies on the localization of potential TSG in neoplastic transformation of prostate comprise chromosome regions 7q, 8p, l0p/q, 16q, 17q, and 18q. In connection with accumulation of genetic changes affecting functioning of critical TSG, the multistep cancer progression hypothesis is a useful starting point in efforts to understand the biology of the neoplastic lesions of prostate.
2

Immunohistochemical assessment of Fhit protein expression in advanced gastric carcinomas in correlation with Helicobacter pylori infection and survival time

84%
Czyzewska J., Guzinska-Ustymowicz K., Pryczynicz A., Kemona A., Bandurski R.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 1
47-53
3

Melanoma and skin cancers in psoriatic patients treated with phototherapy. Role of the p16 protein in psoriasis

84%
Szponar-Bojda A., Pietrzak A., Sobczynska-Tomaszewska A., Borzecki A., Kurylcio A., Polkowski W., Poluha A., Chodorowska G.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 4
4

Quantification of P21 mRNA in biopsy specimens of colon tissue at different stages of neoplastic transformation

84%
Dzierzewicz Z., Kwapisz I., Orchel A., Hudyka K., Wilczok T.
Folia Histochemica et Cytobiologica. Supplement
|
2001
|
tom 39
|
nr 1
5

Sialyl Lewisa: a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells

84%
Ugorski M., Laskowska A.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 2
Neoplastic transformation is often associated with characteristic changes in the ex­pression of the sialyl Lewisa and sialyl Lewisx antigens, representing typical tu­mor-associated carbohydrate antigens. High amounts of sialyl Lewisa are present in hu­man adenocarcinomas of the colon, pancreas and stomach. A growing amount of data suggests that this carbohydrate structure is the ligand for E-selectin. Sialylated Lewis structures present on the surface of tumor cells are carried by the carbohydrate chains of glycoproteins and glycolipids. There are several lines of evidence showing that sialyl Lewisa is responsible for the adhesion of human cancer cells to endothelium. E-selectin present on endothelial cells mediates these interactions. Selectins and their carbohy­drate ligands can thus play an important role in the selective homing of tumor cells dur­ing metastasis. However, the presence of sialyl Lewisa antigen on the surface of tumor cells and their adhesion to E-selectin-expressing cells in in vitro adhesion assay by itself can not be directly related to metastatic properties of all cancer cells.
6
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Human cytomegalovirus infection as a lifelong health problem

67%
Figlerowicz M., Modlinska-Cwalinska A., Mania A., Mazur-Melewska K., Kemnitz P., Jonczyk-Potoczna K., Sluzewski W.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2011
|
tom 92
|
nr 4
7

Mast cells evaluation in meningioma of various grades

67%
Reszec J., Hermanowicz A., Kochanowicz J., Turek G., Mariak Z., Chyczewski L.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 4
8

The aromatase expression in myomas and myometriums of women in reproduction and perimenopausal age

67%
Madej P., Plewka A., Plewka D., Palen P., Nowaczyk G., Bogunia E., Marczynski J., Waloszek J.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 3
9
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Effect of gliclazide on nucleotide excision repair [NER] and non-homologous DNA end joining [NHEJ] in normal and cancer cells

67%
Sliwinska A., Sliwinski T., Kasznicki J., Drzewoski J.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 3
347-353
The results of clinical studies revealed that gliclazide may reduce the risk of cancer in type 2 diabetic patients (T2DM), although the mechanism of possible protective effect is not sufficiently explored. The increased level of DNA damage and impaired DNA repair system in diabetes mellitus may play a substantial role in neoplastic transformation. Recently, we have demonstrated that gliclazide protected DNA against damage introduced by the oxidative stress, but its action on the DNA repair mechanisms is unclear. Therefore, the aim of this study was to assess whether gliclazide has any effect on the DNA repair pathways, e.g. nucleotide excision repair (NER) and non-homologous end joining (NHEJ). NER activity was assessed in the extract of human lymphocytes and pancreatic cancer cells (PANC-1) treated or not with gliclazide by use of an UV-irradiated plasmid as a substrate and by quantitative PCR performed to evaluate the efficacy of the removal of UV-induced lesions from the p53 gene by intact cells. The efficacy of NHEJ pathway was examined by a simple and rapid in vitro assay based on fluorescent detection of repair products. We did not observe significant differences between the efficiency of NER and NHEJ for extracts of lymphocytes alone and lymphocytes treated with gliclazide. Contrary, gliclazide increased the efficacy of NER (46.0% vs. 84.0%, p<0.01) and NHEJ (58.0% vs. 66.0%, p<0.05) in PANC-1 cells. In conclusion, the present study showed that gliclazide did not affect NER and NHEJ in human normal cells, but it may stimulate DNA repair in cancer cells.
10
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Modulation of oxidative DNA damage repair by the diet, inflammation and neoplastic transformation

59%
Tudek B., Swoboda M., Kowalczyk P., Olinski R.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 7
33-49
Oxidative DNA damage and DNA repair may mediate several cellular processes, like replication and transcription, mutagenesis and apoptosis and thus may be important for the organism development as well as its pathogenesis, including cancer. Activity of DNA repair enzymes can depend on many factors, such as gene polymorphism, mRNA and protein level, as well as enzymes activation and inhibition. Modulation of base excision repair pathway eliminating from DNA oxidatively formed lesions may be caused by the diet, inflammation and neoplastic transformation. Reactive oxygen species and some diet components induce transcription of several Base Excision Repair enzymes, e.g. major human AP-endonuclease, (APE1) and 8-oxoG-DNA glycosylase (OGG1). The carcinogenic process in human lungs decreases repair activity for 8-oxoG in transcription independent manner, but increases repair activity of eA and eC, as measured in tumors and unchanged lung tissues of lung cancer patients. Thus, modulation of repair enzymes activities may be a cell response on their way to differentiation or neoplastic transformation.
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